The Relationship Between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead
The purpose of this work was to assess the influence of selected CNR1, MC4R, LEP, FTO and VDR FOKI gene polymorphisms on blood and urine concentration markers of lead, cadmium and arsenic in a population directly exposed to these metals. Eighty-five people exposed to lead, arsenic and cadmium were q...
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| Veröffentlicht in: | Journal of clinical medicine 2020-04, Vol.9 (4), p.1040 |
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| creator | Matys, Tomasz Szymańska-Chabowska, Anna Bogunia-Kubik, Katarzyna Smyk, Beata Kamińska, Małgorzata Mazur, Grzegorz Poręba, Rafał Gać, Paweł |
| description | The purpose of this work was to assess the influence of selected CNR1, MC4R, LEP, FTO and VDR FOKI gene polymorphisms on blood and urine concentration markers of lead, cadmium and arsenic in a population directly exposed to these metals. Eighty-five people exposed to lead, arsenic and cadmium were qualified to take part in the study. Standard urine samples and 25mL of venous blood from each worker were collected to assay basic laboratory and toxicological markers as well as selected single nucleotide polymorphisms (SNPs) within CNR1-cannabinoid receptor 1 gene (
), MC4R-melanocortin 4 receptor gene (
), LEP-leptin promoter gene (
), FTO-alpha-ketoglutarate-dependent dioxygenase gene (
) and VDR-vitamin D receptor (
) genes. It appeared that, except for the MC4R SNP, all the other polymorphisms were found to be associated with various laboratory parameters. Arsenic concentration in urine was associated with all four CNR1 and LEP SNPs, while cadmium concentration in blood was affected by the VDR polymorphism. Moreover, some significant relationships were also observed between CNR1
and FTO
gene variants and markers of lead exposure. These results imply SNPs within genes coding for proteins involved in development of metabolic syndrome may be of prognostic value for persons directly exposed to lead, cadmium and arsenic. |
| doi_str_mv | 10.3390/jcm9041040 |
| format | Article |
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), MC4R-melanocortin 4 receptor gene (
), LEP-leptin promoter gene (
), FTO-alpha-ketoglutarate-dependent dioxygenase gene (
) and VDR-vitamin D receptor (
) genes. It appeared that, except for the MC4R SNP, all the other polymorphisms were found to be associated with various laboratory parameters. Arsenic concentration in urine was associated with all four CNR1 and LEP SNPs, while cadmium concentration in blood was affected by the VDR polymorphism. Moreover, some significant relationships were also observed between CNR1
and FTO
gene variants and markers of lead exposure. These results imply SNPs within genes coding for proteins involved in development of metabolic syndrome may be of prognostic value for persons directly exposed to lead, cadmium and arsenic.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9041040</identifier><identifier>PMID: 32272684</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipocytes ; Body mass index ; Cadmium ; Cholesterol ; Chromosomes ; Clinical medicine ; Diabetes ; Heavy metals ; High density lipoprotein ; Hypertension ; Insulin resistance ; Laboratories ; Lead content ; Metabolic disorders ; Metabolic syndrome ; Nervous system ; Obesity ; Occupational health ; Polymorphism ; Reference materials ; Scientific imaging ; Triglycerides ; Urine ; Vitamin D</subject><ispartof>Journal of clinical medicine, 2020-04, Vol.9 (4), p.1040</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-6b932336bf052fd2fcdd5ac44c5ecd00fde3f186a824a579ed65fd0c743f87533</citedby><cites>FETCH-LOGICAL-c406t-6b932336bf052fd2fcdd5ac44c5ecd00fde3f186a824a579ed65fd0c743f87533</cites><orcidid>0000-0001-6610-2008 ; 0000-0001-8366-0239</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230590/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230590/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32272684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matys, Tomasz</creatorcontrib><creatorcontrib>Szymańska-Chabowska, Anna</creatorcontrib><creatorcontrib>Bogunia-Kubik, Katarzyna</creatorcontrib><creatorcontrib>Smyk, Beata</creatorcontrib><creatorcontrib>Kamińska, Małgorzata</creatorcontrib><creatorcontrib>Mazur, Grzegorz</creatorcontrib><creatorcontrib>Poręba, Rafał</creatorcontrib><creatorcontrib>Gać, Paweł</creatorcontrib><title>The Relationship Between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>The purpose of this work was to assess the influence of selected CNR1, MC4R, LEP, FTO and VDR FOKI gene polymorphisms on blood and urine concentration markers of lead, cadmium and arsenic in a population directly exposed to these metals. Eighty-five people exposed to lead, arsenic and cadmium were qualified to take part in the study. Standard urine samples and 25mL of venous blood from each worker were collected to assay basic laboratory and toxicological markers as well as selected single nucleotide polymorphisms (SNPs) within CNR1-cannabinoid receptor 1 gene (
), MC4R-melanocortin 4 receptor gene (
), LEP-leptin promoter gene (
), FTO-alpha-ketoglutarate-dependent dioxygenase gene (
) and VDR-vitamin D receptor (
) genes. It appeared that, except for the MC4R SNP, all the other polymorphisms were found to be associated with various laboratory parameters. Arsenic concentration in urine was associated with all four CNR1 and LEP SNPs, while cadmium concentration in blood was affected by the VDR polymorphism. Moreover, some significant relationships were also observed between CNR1
and FTO
gene variants and markers of lead exposure. These results imply SNPs within genes coding for proteins involved in development of metabolic syndrome may be of prognostic value for persons directly exposed to lead, cadmium and arsenic.</description><subject>Adipocytes</subject><subject>Body mass index</subject><subject>Cadmium</subject><subject>Cholesterol</subject><subject>Chromosomes</subject><subject>Clinical medicine</subject><subject>Diabetes</subject><subject>Heavy metals</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Insulin resistance</subject><subject>Laboratories</subject><subject>Lead content</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Nervous system</subject><subject>Obesity</subject><subject>Occupational health</subject><subject>Polymorphism</subject><subject>Reference materials</subject><subject>Scientific imaging</subject><subject>Triglycerides</subject><subject>Urine</subject><subject>Vitamin D</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdUttuEzEQXSEQrUpf-ABkiReEEvBtby9I6ZIWpECiNPC6cuzZxJG9Xuzd0vwc34aTllKYlxnNHJ1zbJ0keUnwO8ZK_H4nbYk5wRw_SU4pzvMxZgV7-mg-Sc5D2OFYRcEpyZ8nJ4zSnGYFP01-rbaAlmBEr10btrpDF9D_BGjRNRiQPShUfV2SEfpS8eUIzaaLEbpczZFoFfr-cYmuoAW0cGZvne-2OthwPF3DDXhh0IUIWqKVu9XSGbfRMu4WwgsLPfiAJta1G7SIYxRHcymH7mhEGLNH09vOhajfOzTxAVotR6gSyurBHjVmINSL5FkjTIDz-36WfLucrqpP49n86nM1mY0lx1k_ztYlo4xl6wantFG0kUqlQnIuU5AK40YBa0iRiYJykeYlqCxtFJY5Z02Rp4ydJR_ueLthbUFJaPv4vLrz2gq_r53Q9b-XVm_rjbupc8pwWuJI8OaewLsfA4S-tjpIMEa04IZQU1YUBUlzctB6_R905wYf_ySiMk4IL3NyIHx7h5LeheCheTBDcH1IRv03GRH86rH9B-ifHLDfR421Cg</recordid><startdate>20200407</startdate><enddate>20200407</enddate><creator>Matys, Tomasz</creator><creator>Szymańska-Chabowska, Anna</creator><creator>Bogunia-Kubik, Katarzyna</creator><creator>Smyk, Beata</creator><creator>Kamińska, Małgorzata</creator><creator>Mazur, Grzegorz</creator><creator>Poręba, Rafał</creator><creator>Gać, Paweł</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6610-2008</orcidid><orcidid>https://orcid.org/0000-0001-8366-0239</orcidid></search><sort><creationdate>20200407</creationdate><title>The Relationship Between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead</title><author>Matys, Tomasz ; Szymańska-Chabowska, Anna ; Bogunia-Kubik, Katarzyna ; Smyk, Beata ; Kamińska, Małgorzata ; Mazur, Grzegorz ; Poręba, Rafał ; Gać, Paweł</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-6b932336bf052fd2fcdd5ac44c5ecd00fde3f186a824a579ed65fd0c743f87533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipocytes</topic><topic>Body mass index</topic><topic>Cadmium</topic><topic>Cholesterol</topic><topic>Chromosomes</topic><topic>Clinical medicine</topic><topic>Diabetes</topic><topic>Heavy metals</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Insulin resistance</topic><topic>Laboratories</topic><topic>Lead content</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Nervous system</topic><topic>Obesity</topic><topic>Occupational health</topic><topic>Polymorphism</topic><topic>Reference materials</topic><topic>Scientific imaging</topic><topic>Triglycerides</topic><topic>Urine</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matys, Tomasz</creatorcontrib><creatorcontrib>Szymańska-Chabowska, Anna</creatorcontrib><creatorcontrib>Bogunia-Kubik, Katarzyna</creatorcontrib><creatorcontrib>Smyk, Beata</creatorcontrib><creatorcontrib>Kamińska, Małgorzata</creatorcontrib><creatorcontrib>Mazur, Grzegorz</creatorcontrib><creatorcontrib>Poręba, Rafał</creatorcontrib><creatorcontrib>Gać, Paweł</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matys, Tomasz</au><au>Szymańska-Chabowska, Anna</au><au>Bogunia-Kubik, Katarzyna</au><au>Smyk, Beata</au><au>Kamińska, Małgorzata</au><au>Mazur, Grzegorz</au><au>Poręba, Rafał</au><au>Gać, Paweł</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship Between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2020-04-07</date><risdate>2020</risdate><volume>9</volume><issue>4</issue><spage>1040</spage><pages>1040-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>The purpose of this work was to assess the influence of selected CNR1, MC4R, LEP, FTO and VDR FOKI gene polymorphisms on blood and urine concentration markers of lead, cadmium and arsenic in a population directly exposed to these metals. Eighty-five people exposed to lead, arsenic and cadmium were qualified to take part in the study. Standard urine samples and 25mL of venous blood from each worker were collected to assay basic laboratory and toxicological markers as well as selected single nucleotide polymorphisms (SNPs) within CNR1-cannabinoid receptor 1 gene (
), MC4R-melanocortin 4 receptor gene (
), LEP-leptin promoter gene (
), FTO-alpha-ketoglutarate-dependent dioxygenase gene (
) and VDR-vitamin D receptor (
) genes. It appeared that, except for the MC4R SNP, all the other polymorphisms were found to be associated with various laboratory parameters. Arsenic concentration in urine was associated with all four CNR1 and LEP SNPs, while cadmium concentration in blood was affected by the VDR polymorphism. Moreover, some significant relationships were also observed between CNR1
and FTO
gene variants and markers of lead exposure. These results imply SNPs within genes coding for proteins involved in development of metabolic syndrome may be of prognostic value for persons directly exposed to lead, cadmium and arsenic.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32272684</pmid><doi>10.3390/jcm9041040</doi><orcidid>https://orcid.org/0000-0001-6610-2008</orcidid><orcidid>https://orcid.org/0000-0001-8366-0239</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical medicine, 2020-04, Vol.9 (4), p.1040 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adipocytes Body mass index Cadmium Cholesterol Chromosomes Clinical medicine Diabetes Heavy metals High density lipoprotein Hypertension Insulin resistance Laboratories Lead content Metabolic disorders Metabolic syndrome Nervous system Obesity Occupational health Polymorphism Reference materials Scientific imaging Triglycerides Urine Vitamin D |
| title | The Relationship Between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead |
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