Advances in the repair of segmental nerve injuries and trends in reconstruction
Despite advances in surgery, the reconstruction of segmental nerve injuries continues to pose challenges. In this review, current neurobiology regarding regeneration across a nerve defect is discussed in detail. Recent findings include the complex roles of nonneuronal cells in nerve defect regenerat...
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| Veröffentlicht in: | Muscle & nerve 2020-06, Vol.61 (6), p.726-739 |
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| creator | Pan, Deng Mackinnon, Susan E. Wood, Matthew D. |
| description | Despite advances in surgery, the reconstruction of segmental nerve injuries continues to pose challenges. In this review, current neurobiology regarding regeneration across a nerve defect is discussed in detail. Recent findings include the complex roles of nonneuronal cells in nerve defect regeneration, such as the role of the innate immune system in angiogenesis and how Schwann cells migrate within the defect. Clinically, the repair of nerve defects is still best served by using nerve autografts with the exception of small, noncritical sensory nerve defects, which can be repaired using autograft alternatives, such as processed or acellular nerve allografts. Given current clinical limits for when alternatives can be used, advanced solutions to repair nerve defects demonstrated in animals are highlighted. These highlights include alternatives designed with novel topology and materials, delivery of drugs specifically known to accelerate axon growth, and greater attention to the role of the immune system. |
| doi_str_mv | 10.1002/mus.26797 |
| format | Article |
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In this review, current neurobiology regarding regeneration across a nerve defect is discussed in detail. Recent findings include the complex roles of nonneuronal cells in nerve defect regeneration, such as the role of the innate immune system in angiogenesis and how Schwann cells migrate within the defect. Clinically, the repair of nerve defects is still best served by using nerve autografts with the exception of small, noncritical sensory nerve defects, which can be repaired using autograft alternatives, such as processed or acellular nerve allografts. Given current clinical limits for when alternatives can be used, advanced solutions to repair nerve defects demonstrated in animals are highlighted. 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These highlights include alternatives designed with novel topology and materials, delivery of drugs specifically known to accelerate axon growth, and greater attention to the role of the immune system.</description><subject>acellular nerve allograft</subject><subject>Allografts</subject><subject>Angiogenesis</subject><subject>autograft</subject><subject>Autografts</subject><subject>Cell migration</subject><subject>Defects</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Immune system</subject><subject>Immunosuppressive agents</subject><subject>Injuries</subject><subject>Innate immunity</subject><subject>nerve gap</subject><subject>nerve guidance conduit</subject><subject>Nervous system</subject><subject>Neurosciences</subject><subject>peripheral nerve</subject><subject>Regeneration</subject><subject>Schwann cells</subject><subject>Sensory neurons</subject><subject>Surgery</subject><subject>Topology</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kctKxDAUhoMoOl4WvoAU3OhiNJembTbCIN5AcaGCu5Amp5qhTcakHfHtzTgqKrjK4nzn489_ENol-IhgTI-7IR7RohTlChoRLMpxzkW1ikaY5NW4YOJxA23GOMUYk6oo19EGI1XFCBUjdDsxc-U0xMy6rH-GLMBM2ZD5Jovw1IHrVZs5CHNIwHQINpHKmawP4MzHUgDtXezDoHvr3TZaa1QbYefz3UIP52f3p5fj69uLq9PJ9VjzRcCG5VVNCswNZcSAKArFoVQm57zmVZWXDBtd1wITitMYmK4N0wKXhDCmecO20MnSOxvqDoxOQYNq5SzYToU36ZWVvyfOPssnP5clZakyngQHn4LgXwaIvexs1NC2yoEfoqQsFVSknmhC9_-gUz8El74naY4ZYSLlT9ThktLBxxig-Q5DsFycSXYL7eJMid37mf6b_LpLAo6XwKtt4e1_k7x5uFsq3wErcp01</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Pan, Deng</creator><creator>Mackinnon, Susan E.</creator><creator>Wood, Matthew D.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8132-6827</orcidid></search><sort><creationdate>202006</creationdate><title>Advances in the repair of segmental nerve injuries and trends in reconstruction</title><author>Pan, Deng ; 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| fulltext | fulltext |
| identifier | ISSN: 0148-639X |
| ispartof | Muscle & nerve, 2020-06, Vol.61 (6), p.726-739 |
| issn | 0148-639X 1097-4598 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | acellular nerve allograft Allografts Angiogenesis autograft Autografts Cell migration Defects Drug delivery Drug delivery systems Immune system Immunosuppressive agents Injuries Innate immunity nerve gap nerve guidance conduit Nervous system Neurosciences peripheral nerve Regeneration Schwann cells Sensory neurons Surgery Topology |
| title | Advances in the repair of segmental nerve injuries and trends in reconstruction |
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