Ten-year trends in the incidence, treatment and outcomes of patients with mitral stenosis in Korea
ObjectiveMitral stenosis increases the risk of atrial fibrillation (AF) and stroke. Large data underlying the trend in incidence, treatment and outcomes of mitral stenosis are lacking.MethodsBased on the Health Insurance Review and Assessment Service database in Republic of Korea, patients who were...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2020-05, Vol.106 (10), p.746-750 |
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| creator | Kim, Ju Youn Kim, Sung-Hwan Myong, Jun Pyo Choi, Young Hwang, You Mi Kim, Tae-Seok Kim, Ji-Hoon Jang, Sung-Won Oh, Yong-Seog Lee, Man-Young |
| description | ObjectiveMitral stenosis increases the risk of atrial fibrillation (AF) and stroke. Large data underlying the trend in incidence, treatment and outcomes of mitral stenosis are lacking.MethodsBased on the Health Insurance Review and Assessment Service database in Republic of Korea, patients who were diagnosed with mitral stenosis between 2007 and 2016 were enrolled. Trends in the incidence rate and changing patterns of treatment and outcome for stroke and systemic embolism and intracranial haemorrhage (ICH) were analysed.ResultsA total of 42 075 patients (mean age 60.7±13.5 years, 13 303 (31.6%) male) were included in the present study. The number included 27 824 (66.1%) patients with mitral stenosis and comorbid AF. The age-standardised annual incidence rate per 100 000 of mitral stenosis in Korea decreased remarkably from 10.3 to 3.6 over 10 years. The use of anticoagulation therapy increased consistently. The annual incidence of stroke and systemic embolism showed signs of plateau, while the incidence of ICH increased.ConclusionsThe overall incidence rate of mitral stenosis in Korean population has decreased remarkably. As increasing the use of vitamin K antagonist, the annual incidence rate of ICH was increased but the rate of stroke incidence reached a plateau. Alternative effective anticoagulation strategy should be investigated. |
| doi_str_mv | 10.1136/heartjnl-2019-315883 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7229898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2393965830</sourcerecordid><originalsourceid>FETCH-LOGICAL-b517t-95a604d352bc6c3765e1631655853e04104304a58ed26bfbd0b107bd6d94b3a43</originalsourceid><addsrcrecordid>eNqNkU9LXDEUxUNpqdb2G0gJdOvT_H_JRhBRKwpuFNyF5CXjZJiXTJOM4rc34-iom-LqhnvP-eXAAWAXo32MqTiYepPrLM47grDqKOZS0i9gGzMhV6vbr-1NOe8Eov0W-FHKDCHElBTfwRYliChO-Daw1z52jw0Fa_bRFRgirFPfxhCcj4PfWx1MHX2s0EQH07IOafQFpglcmBravsCHUKdwDDWbOSzVx1TCM-kiNe9P8G1i5sX_epk74Ob05Pr4b3d5dXZ-fHTZWY772iluBGKOcmIHMdBecI8FxYJzyalHDCNGETNcekeEnViHLEa9dcIpZqlhdAccrrmLpR29G1qylkcvchhNftTJBP3xEsNU36V73ROipJIN8OcFkNO_pS9Vz9Iyx5ZZE6qoElxS1FRsrRpyKiX7yeYHjPSqGf3ajF41o9fNNNvv9-k2ptcqmuBgLbDj7LNI9ObYRP2v5Qn--6vz</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2393965830</pqid></control><display><type>article</type><title>Ten-year trends in the incidence, treatment and outcomes of patients with mitral stenosis in Korea</title><source>MEDLINE</source><source>PubMed Central</source><creator>Kim, Ju Youn ; Kim, Sung-Hwan ; Myong, Jun Pyo ; Choi, Young ; Hwang, You Mi ; Kim, Tae-Seok ; Kim, Ji-Hoon ; Jang, Sung-Won ; Oh, Yong-Seog ; Lee, Man-Young</creator><creatorcontrib>Kim, Ju Youn ; Kim, Sung-Hwan ; Myong, Jun Pyo ; Choi, Young ; Hwang, You Mi ; Kim, Tae-Seok ; Kim, Ji-Hoon ; Jang, Sung-Won ; Oh, Yong-Seog ; Lee, Man-Young</creatorcontrib><description>ObjectiveMitral stenosis increases the risk of atrial fibrillation (AF) and stroke. Large data underlying the trend in incidence, treatment and outcomes of mitral stenosis are lacking.MethodsBased on the Health Insurance Review and Assessment Service database in Republic of Korea, patients who were diagnosed with mitral stenosis between 2007 and 2016 were enrolled. Trends in the incidence rate and changing patterns of treatment and outcome for stroke and systemic embolism and intracranial haemorrhage (ICH) were analysed.ResultsA total of 42 075 patients (mean age 60.7±13.5 years, 13 303 (31.6%) male) were included in the present study. The number included 27 824 (66.1%) patients with mitral stenosis and comorbid AF. The age-standardised annual incidence rate per 100 000 of mitral stenosis in Korea decreased remarkably from 10.3 to 3.6 over 10 years. The use of anticoagulation therapy increased consistently. The annual incidence of stroke and systemic embolism showed signs of plateau, while the incidence of ICH increased.ConclusionsThe overall incidence rate of mitral stenosis in Korean population has decreased remarkably. As increasing the use of vitamin K antagonist, the annual incidence rate of ICH was increased but the rate of stroke incidence reached a plateau. Alternative effective anticoagulation strategy should be investigated.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2019-315883</identifier><identifier>PMID: 32029525</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Age ; Anticoagulants ; Anticoagulants - therapeutic use ; anticoagulation ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - etiology ; Atrial Fibrillation - therapy ; Cardiac arrhythmia ; Chronic obstructive pulmonary disease ; Codes ; Databases, Factual - statistics & numerical data ; Disease ; Embolism - epidemiology ; Embolism - etiology ; Embolism - prevention & control ; Embolisms ; Female ; Humans ; Incidence ; incidence rate ; intracranial haemorrhage ; Intracranial Hemorrhages - epidemiology ; Intracranial Hemorrhages - etiology ; Male ; Middle Aged ; mitral stenosis ; Mitral Valve Stenosis - complications ; Mitral Valve Stenosis - epidemiology ; Mitral Valve Stenosis - therapy ; Republic of Korea - epidemiology ; Rheumatic fever ; Risk Factors ; Statistical analysis ; Stroke ; Stroke - epidemiology ; Stroke - etiology ; Stroke - prevention & control ; systemic embolism ; Thromboembolism ; Trends ; Valvular Heart Disease</subject><ispartof>Heart (British Cardiac Society), 2020-05, Vol.106 (10), p.746-750</ispartof><rights>Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b517t-95a604d352bc6c3765e1631655853e04104304a58ed26bfbd0b107bd6d94b3a43</citedby><cites>FETCH-LOGICAL-b517t-95a604d352bc6c3765e1631655853e04104304a58ed26bfbd0b107bd6d94b3a43</cites><orcidid>0000-0002-5323-3428</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229898/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229898/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32029525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ju Youn</creatorcontrib><creatorcontrib>Kim, Sung-Hwan</creatorcontrib><creatorcontrib>Myong, Jun Pyo</creatorcontrib><creatorcontrib>Choi, Young</creatorcontrib><creatorcontrib>Hwang, You Mi</creatorcontrib><creatorcontrib>Kim, Tae-Seok</creatorcontrib><creatorcontrib>Kim, Ji-Hoon</creatorcontrib><creatorcontrib>Jang, Sung-Won</creatorcontrib><creatorcontrib>Oh, Yong-Seog</creatorcontrib><creatorcontrib>Lee, Man-Young</creatorcontrib><title>Ten-year trends in the incidence, treatment and outcomes of patients with mitral stenosis in Korea</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><addtitle>Heart</addtitle><description>ObjectiveMitral stenosis increases the risk of atrial fibrillation (AF) and stroke. Large data underlying the trend in incidence, treatment and outcomes of mitral stenosis are lacking.MethodsBased on the Health Insurance Review and Assessment Service database in Republic of Korea, patients who were diagnosed with mitral stenosis between 2007 and 2016 were enrolled. Trends in the incidence rate and changing patterns of treatment and outcome for stroke and systemic embolism and intracranial haemorrhage (ICH) were analysed.ResultsA total of 42 075 patients (mean age 60.7±13.5 years, 13 303 (31.6%) male) were included in the present study. The number included 27 824 (66.1%) patients with mitral stenosis and comorbid AF. The age-standardised annual incidence rate per 100 000 of mitral stenosis in Korea decreased remarkably from 10.3 to 3.6 over 10 years. The use of anticoagulation therapy increased consistently. The annual incidence of stroke and systemic embolism showed signs of plateau, while the incidence of ICH increased.ConclusionsThe overall incidence rate of mitral stenosis in Korean population has decreased remarkably. As increasing the use of vitamin K antagonist, the annual incidence rate of ICH was increased but the rate of stroke incidence reached a plateau. Alternative effective anticoagulation strategy should be investigated.</description><subject>Age</subject><subject>Anticoagulants</subject><subject>Anticoagulants - therapeutic use</subject><subject>anticoagulation</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - therapy</subject><subject>Cardiac arrhythmia</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Codes</subject><subject>Databases, Factual - statistics & numerical data</subject><subject>Disease</subject><subject>Embolism - epidemiology</subject><subject>Embolism - etiology</subject><subject>Embolism - prevention & control</subject><subject>Embolisms</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>incidence rate</subject><subject>intracranial haemorrhage</subject><subject>Intracranial Hemorrhages - epidemiology</subject><subject>Intracranial Hemorrhages - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>mitral stenosis</subject><subject>Mitral Valve Stenosis - complications</subject><subject>Mitral Valve Stenosis - epidemiology</subject><subject>Mitral Valve Stenosis - therapy</subject><subject>Republic of Korea - epidemiology</subject><subject>Rheumatic fever</subject><subject>Risk Factors</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Stroke - prevention & control</subject><subject>systemic embolism</subject><subject>Thromboembolism</subject><subject>Trends</subject><subject>Valvular Heart Disease</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9LXDEUxUNpqdb2G0gJdOvT_H_JRhBRKwpuFNyF5CXjZJiXTJOM4rc34-iom-LqhnvP-eXAAWAXo32MqTiYepPrLM47grDqKOZS0i9gGzMhV6vbr-1NOe8Eov0W-FHKDCHElBTfwRYliChO-Daw1z52jw0Fa_bRFRgirFPfxhCcj4PfWx1MHX2s0EQH07IOafQFpglcmBravsCHUKdwDDWbOSzVx1TCM-kiNe9P8G1i5sX_epk74Ob05Pr4b3d5dXZ-fHTZWY772iluBGKOcmIHMdBecI8FxYJzyalHDCNGETNcekeEnViHLEa9dcIpZqlhdAccrrmLpR29G1qylkcvchhNftTJBP3xEsNU36V73ROipJIN8OcFkNO_pS9Vz9Iyx5ZZE6qoElxS1FRsrRpyKiX7yeYHjPSqGf3ajF41o9fNNNvv9-k2ptcqmuBgLbDj7LNI9ObYRP2v5Qn--6vz</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Kim, Ju Youn</creator><creator>Kim, Sung-Hwan</creator><creator>Myong, Jun Pyo</creator><creator>Choi, Young</creator><creator>Hwang, You Mi</creator><creator>Kim, Tae-Seok</creator><creator>Kim, Ji-Hoon</creator><creator>Jang, Sung-Won</creator><creator>Oh, Yong-Seog</creator><creator>Lee, Man-Young</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5323-3428</orcidid></search><sort><creationdate>20200501</creationdate><title>Ten-year trends in the incidence, treatment and outcomes of patients with mitral stenosis in Korea</title><author>Kim, Ju Youn ; Kim, Sung-Hwan ; Myong, Jun Pyo ; Choi, Young ; Hwang, You Mi ; Kim, Tae-Seok ; Kim, Ji-Hoon ; Jang, Sung-Won ; Oh, Yong-Seog ; Lee, Man-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b517t-95a604d352bc6c3765e1631655853e04104304a58ed26bfbd0b107bd6d94b3a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Anticoagulants</topic><topic>Anticoagulants - therapeutic use</topic><topic>anticoagulation</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - therapy</topic><topic>Cardiac arrhythmia</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Codes</topic><topic>Databases, Factual - statistics & numerical data</topic><topic>Disease</topic><topic>Embolism - epidemiology</topic><topic>Embolism - etiology</topic><topic>Embolism - prevention & control</topic><topic>Embolisms</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>incidence rate</topic><topic>intracranial haemorrhage</topic><topic>Intracranial Hemorrhages - epidemiology</topic><topic>Intracranial Hemorrhages - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>mitral stenosis</topic><topic>Mitral Valve Stenosis - complications</topic><topic>Mitral Valve Stenosis - epidemiology</topic><topic>Mitral Valve Stenosis - therapy</topic><topic>Republic of Korea - epidemiology</topic><topic>Rheumatic fever</topic><topic>Risk Factors</topic><topic>Statistical analysis</topic><topic>Stroke</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>Stroke - prevention & control</topic><topic>systemic embolism</topic><topic>Thromboembolism</topic><topic>Trends</topic><topic>Valvular Heart Disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ju Youn</creatorcontrib><creatorcontrib>Kim, Sung-Hwan</creatorcontrib><creatorcontrib>Myong, Jun Pyo</creatorcontrib><creatorcontrib>Choi, Young</creatorcontrib><creatorcontrib>Hwang, You Mi</creatorcontrib><creatorcontrib>Kim, Tae-Seok</creatorcontrib><creatorcontrib>Kim, Ji-Hoon</creatorcontrib><creatorcontrib>Jang, Sung-Won</creatorcontrib><creatorcontrib>Oh, Yong-Seog</creatorcontrib><creatorcontrib>Lee, Man-Young</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ju Youn</au><au>Kim, Sung-Hwan</au><au>Myong, Jun Pyo</au><au>Choi, Young</au><au>Hwang, You Mi</au><au>Kim, Tae-Seok</au><au>Kim, Ji-Hoon</au><au>Jang, Sung-Won</au><au>Oh, Yong-Seog</au><au>Lee, Man-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ten-year trends in the incidence, treatment and outcomes of patients with mitral stenosis in Korea</atitle><jtitle>Heart (British Cardiac Society)</jtitle><stitle>Heart</stitle><addtitle>Heart</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>106</volume><issue>10</issue><spage>746</spage><epage>750</epage><pages>746-750</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>ObjectiveMitral stenosis increases the risk of atrial fibrillation (AF) and stroke. Large data underlying the trend in incidence, treatment and outcomes of mitral stenosis are lacking.MethodsBased on the Health Insurance Review and Assessment Service database in Republic of Korea, patients who were diagnosed with mitral stenosis between 2007 and 2016 were enrolled. Trends in the incidence rate and changing patterns of treatment and outcome for stroke and systemic embolism and intracranial haemorrhage (ICH) were analysed.ResultsA total of 42 075 patients (mean age 60.7±13.5 years, 13 303 (31.6%) male) were included in the present study. The number included 27 824 (66.1%) patients with mitral stenosis and comorbid AF. The age-standardised annual incidence rate per 100 000 of mitral stenosis in Korea decreased remarkably from 10.3 to 3.6 over 10 years. The use of anticoagulation therapy increased consistently. The annual incidence of stroke and systemic embolism showed signs of plateau, while the incidence of ICH increased.ConclusionsThe overall incidence rate of mitral stenosis in Korean population has decreased remarkably. As increasing the use of vitamin K antagonist, the annual incidence rate of ICH was increased but the rate of stroke incidence reached a plateau. Alternative effective anticoagulation strategy should be investigated.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>32029525</pmid><doi>10.1136/heartjnl-2019-315883</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5323-3428</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Anticoagulants Anticoagulants - therapeutic use anticoagulation Atrial Fibrillation - epidemiology Atrial Fibrillation - etiology Atrial Fibrillation - therapy Cardiac arrhythmia Chronic obstructive pulmonary disease Codes Databases, Factual - statistics & numerical data Disease Embolism - epidemiology Embolism - etiology Embolism - prevention & control Embolisms Female Humans Incidence incidence rate intracranial haemorrhage Intracranial Hemorrhages - epidemiology Intracranial Hemorrhages - etiology Male Middle Aged mitral stenosis Mitral Valve Stenosis - complications Mitral Valve Stenosis - epidemiology Mitral Valve Stenosis - therapy Republic of Korea - epidemiology Rheumatic fever Risk Factors Statistical analysis Stroke Stroke - epidemiology Stroke - etiology Stroke - prevention & control systemic embolism Thromboembolism Trends Valvular Heart Disease |
| title | Ten-year trends in the incidence, treatment and outcomes of patients with mitral stenosis in Korea |
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