Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation

The gene encoding the core spliceosomal protein SF3B1 is the most frequently mutated gene encoding a splicing factor in a variety of hematologic malignancies and solid tumors. SF3B1 mutations induce use of cryptic 3′ splice sites (3′ss), and these splicing errors contribute to tumorigenesis. However...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-05, Vol.117 (19), p.10305-10312
Hauptverfasser:	Liu, Zhaoqi, Zhang, Jian, Sun, Yiwei, Perea-Chamblee, Tomin E., Manley, James L., Rabadan, Raul
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cancer Genetic analysis Mutants Mutation Solid tumors Splicing Splicing factors Tumorigenesis Zebrafish
Online-Zugang:	Volltext
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