Optical Control of Small Molecule-Induced Protein Degradation
As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadly applicable approach for the optical activation o...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Chemical Society 2020-02, Vol.142 (5), p.2193-2197 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2197 |
|---|---|
| container_issue | 5 |
| container_start_page | 2193 |
| container_title | Journal of the American Chemical Society |
| container_volume | 142 |
| creator | Naro, Yuta Darrah, Kristie Deiters, Alexander |
| description | As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadly applicable approach for the optical activation of small molecule-induced protein degradation. By installing two different photolabile protecting groups, so-called caging groups, onto two different ligands recruiting Von Hippel–Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered protein degradation for any small molecule warhead. |
| doi_str_mv | 10.1021/jacs.9b12718 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7229639</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2986133139</sourcerecordid><originalsourceid>FETCH-LOGICAL-a516t-cd1baf83d16f31b22abaab85b5bc6303a1eca79097d68bea18a6ab8e00b07e1d3</originalsourceid><addsrcrecordid>eNqNkctLxDAQxoMo7vq4eZYePVjNJDZNDwqyvhaUFdRzmKSpdsk2a9IK_vd22fUFHjwNw_zmm8dHyB7QI6AMjqdo4lGhgeUg18gQMkbTDJhYJ0NKKUtzKfiAbMU47dMTJmGTDDgULC-kHJLTybytDbpk5Js2eJf4KnmYoXPJnXfWdM6m46bsjC2T--BbWzfJhX0OWGJb-2aHbFToot1dxW3ydHX5OLpJbyfX49H5bYoZiDY1JWisJC9BVBw0Y6gRtcx0po3glCNYg3lBi7wUUlsEiaKvW0o1zS2UfJucLXXnnZ7Z0th-V3RqHuoZhnflsVa_K039op79m8oZKwQveoGDlUDwr52NrZrV0VjnsLG-i4oVUgDn8B-Uc0kzKXPRo4dL1AQfY7DV10ZA1cIctTBHrczp8f2fV3zBn258j150TX0Xmv6pf2t9AOBXmSM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2338058876</pqid></control><display><type>article</type><title>Optical Control of Small Molecule-Induced Protein Degradation</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Naro, Yuta ; Darrah, Kristie ; Deiters, Alexander</creator><creatorcontrib>Naro, Yuta ; Darrah, Kristie ; Deiters, Alexander</creatorcontrib><description>As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadly applicable approach for the optical activation of small molecule-induced protein degradation. By installing two different photolabile protecting groups, so-called caging groups, onto two different ligands recruiting Von Hippel–Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered protein degradation for any small molecule warhead.</description><identifier>ISSN: 0002-7863</identifier><identifier>ISSN: 1520-5126</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/jacs.9b12718</identifier><identifier>PMID: 31927988</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Ligands ; protein degradation ; Proteolysis ; Small Molecule Libraries - chemistry ; therapeutics ; ubiquitin-protein ligase ; Ubiquitin-Protein Ligases - metabolism ; Ubiquitination</subject><ispartof>Journal of the American Chemical Society, 2020-02, Vol.142 (5), p.2193-2197</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a516t-cd1baf83d16f31b22abaab85b5bc6303a1eca79097d68bea18a6ab8e00b07e1d3</citedby><cites>FETCH-LOGICAL-a516t-cd1baf83d16f31b22abaab85b5bc6303a1eca79097d68bea18a6ab8e00b07e1d3</cites><orcidid>0000-0003-0234-9209</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jacs.9b12718$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jacs.9b12718$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,776,780,881,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31927988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naro, Yuta</creatorcontrib><creatorcontrib>Darrah, Kristie</creatorcontrib><creatorcontrib>Deiters, Alexander</creatorcontrib><title>Optical Control of Small Molecule-Induced Protein Degradation</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadly applicable approach for the optical activation of small molecule-induced protein degradation. By installing two different photolabile protecting groups, so-called caging groups, onto two different ligands recruiting Von Hippel–Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered protein degradation for any small molecule warhead.</description><subject>Ligands</subject><subject>protein degradation</subject><subject>Proteolysis</subject><subject>Small Molecule Libraries - chemistry</subject><subject>therapeutics</subject><subject>ubiquitin-protein ligase</subject><subject>Ubiquitin-Protein Ligases - metabolism</subject><subject>Ubiquitination</subject><issn>0002-7863</issn><issn>1520-5126</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctLxDAQxoMo7vq4eZYePVjNJDZNDwqyvhaUFdRzmKSpdsk2a9IK_vd22fUFHjwNw_zmm8dHyB7QI6AMjqdo4lGhgeUg18gQMkbTDJhYJ0NKKUtzKfiAbMU47dMTJmGTDDgULC-kHJLTybytDbpk5Js2eJf4KnmYoXPJnXfWdM6m46bsjC2T--BbWzfJhX0OWGJb-2aHbFToot1dxW3ydHX5OLpJbyfX49H5bYoZiDY1JWisJC9BVBw0Y6gRtcx0po3glCNYg3lBi7wUUlsEiaKvW0o1zS2UfJucLXXnnZ7Z0th-V3RqHuoZhnflsVa_K039op79m8oZKwQveoGDlUDwr52NrZrV0VjnsLG-i4oVUgDn8B-Uc0kzKXPRo4dL1AQfY7DV10ZA1cIctTBHrczp8f2fV3zBn258j150TX0Xmv6pf2t9AOBXmSM</recordid><startdate>20200205</startdate><enddate>20200205</enddate><creator>Naro, Yuta</creator><creator>Darrah, Kristie</creator><creator>Deiters, Alexander</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0234-9209</orcidid></search><sort><creationdate>20200205</creationdate><title>Optical Control of Small Molecule-Induced Protein Degradation</title><author>Naro, Yuta ; Darrah, Kristie ; Deiters, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a516t-cd1baf83d16f31b22abaab85b5bc6303a1eca79097d68bea18a6ab8e00b07e1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Ligands</topic><topic>protein degradation</topic><topic>Proteolysis</topic><topic>Small Molecule Libraries - chemistry</topic><topic>therapeutics</topic><topic>ubiquitin-protein ligase</topic><topic>Ubiquitin-Protein Ligases - metabolism</topic><topic>Ubiquitination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naro, Yuta</creatorcontrib><creatorcontrib>Darrah, Kristie</creatorcontrib><creatorcontrib>Deiters, Alexander</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naro, Yuta</au><au>Darrah, Kristie</au><au>Deiters, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical Control of Small Molecule-Induced Protein Degradation</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2020-02-05</date><risdate>2020</risdate><volume>142</volume><issue>5</issue><spage>2193</spage><epage>2197</epage><pages>2193-2197</pages><issn>0002-7863</issn><issn>1520-5126</issn><eissn>1520-5126</eissn><abstract>As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadly applicable approach for the optical activation of small molecule-induced protein degradation. By installing two different photolabile protecting groups, so-called caging groups, onto two different ligands recruiting Von Hippel–Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered protein degradation for any small molecule warhead.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>31927988</pmid><doi>10.1021/jacs.9b12718</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0234-9209</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-7863 |
| ispartof | Journal of the American Chemical Society, 2020-02, Vol.142 (5), p.2193-2197 |
| issn | 0002-7863 1520-5126 1520-5126 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7229639 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Ligands protein degradation Proteolysis Small Molecule Libraries - chemistry therapeutics ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination |
| title | Optical Control of Small Molecule-Induced Protein Degradation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T22%3A31%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Optical%20Control%20of%20Small%20Molecule-Induced%20Protein%20Degradation&rft.jtitle=Journal%20of%20the%20American%20Chemical%20Society&rft.au=Naro,%20Yuta&rft.date=2020-02-05&rft.volume=142&rft.issue=5&rft.spage=2193&rft.epage=2197&rft.pages=2193-2197&rft.issn=0002-7863&rft.eissn=1520-5126&rft_id=info:doi/10.1021/jacs.9b12718&rft_dat=%3Cproquest_pubme%3E2986133139%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2338058876&rft_id=info:pmid/31927988&rfr_iscdi=true |