Bifurcating electron-transfer pathways in DNA photolyases determine the repair quantum yield

Photolyase is a blue-light-activated enzyme that repairs ultraviolet-induced DNA damage that occurs in the form of cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4) photoproducts. Previous studies on microbial photolyases have revealed an electrontunneling pathway that is critical...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2016-10, Vol.354 (6309), p.209-213
Hauptverfasser:	Zhang, Meng, Wang, Lijuan, Shu, Shi, Sancar, Aziz, Zhong, Dongping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bifurcations Coenzymes - chemistry Compounding Compounds Cyclobutane Deoxyribodipyrimidine Photo-Lyase - chemistry Deoxyribodipyrimidine Photo-Lyase - classification Deoxyribonucleic acid Dinitrocresols - chemistry DNA - chemistry DNA Damage DNA Repair Electron Transport Electrons Enzymes Eukaryotic Cells - enzymology Pathways Phylogeny Protein Conformation Pyrimidine Dimers - chemistry Quantum physics Quantum Theory Repair Spectroscopy Spectrum Analysis - methods Substrate Specificity Ultraviolet Rays
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