Contribution of Macrophages and T Cells in Skeletal Metastasis
Bone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with myeloid and lymphoid linage cells that provide a fertile niche for metastatic cancer cells promoting their survival and growth. Here, we dis...
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Veröffentlicht in: | Cancers 2020-04, Vol.12 (4), p.1014 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Bone is a common site for metastases with a local microenvironment that is highly conducive for tumor establishment and growth. The bone marrow is replete with myeloid and lymphoid linage cells that provide a fertile niche for metastatic cancer cells promoting their survival and growth. Here, we discuss the role of macrophages and T cells in pro- and anti-tumoral mechanisms, their interaction to support cancer cell growth, and their contribution to the development of skeletal metastases. Importantly, immunotherapeutic strategies targeting macrophages and T cells in cancer are also discussed in this review as they represent a great promise for patients suffering from incurable bone metastases. |
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ISSN: | 2072-6694 2072-6694 |
DOI: | 10.3390/cancers12041014 |