Utility of isocitrate dehydrogenase 1 as a serum protein biomarker for the early detection of non‐small‐cell lung cancer: A multicenter in vitro diagnostic clinical trial

Utility of isocitrate dehydrogenase 1 as a serum protein biomarker for the early detection of non‐small‐cell lung cancer: A multicenter in vitro diagnostic clinical trial

We aimed to verify the expression status and diagnostic significance of isocitrate dehydrogenase 1 (IDH1) in non‐small‐cell lung cancer (NSCLC), especially during early stages. Serum IDH1 levels were measured by ELISA. A total of 1223 participants (660 patients with NSCLC, 276 healthy controls [HCs]...

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Veröffentlicht in:Cancer science 2020-05, Vol.111 (5), p.1739-1749
Hauptverfasser: Sun, Nan, Sun, Shouguo, Gao, Yibo, Li, Yuan, Lu, Zhiliang, Yuan, Zuyang, Che, Yun, Huang, Jianbing, Mao, Shuangshuang, Lei, Yuanyuan, Zang, Ruochuan, Li, Ning, Cui, Wei, Qi, Jun, Chen, Feng, Gao, Jia, Wang, Jinling, Min, Rong, Chen, Yan, Shi, Guangli, Tan, Fengwei, He, Jie
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
blood biomarker
Cancer therapies
Clinical trials
Dehydrogenases
diagnosis
Disease
early detection
Enzymes
Hospitals
IDH1
Isocitrate dehydrogenase
Lung cancer
Medical prognosis
Medical screening
MicroRNAs
Mortality
Mutation
Non-small cell lung carcinoma
NSCLC
Original
Tomography
Tumors
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Zusammenfassung:We aimed to verify the expression status and diagnostic significance of isocitrate dehydrogenase 1 (IDH1) in non‐small‐cell lung cancer (NSCLC), especially during early stages. Serum IDH1 levels were measured by ELISA. A total of 1223 participants (660 patients with NSCLC, 276 healthy controls [HCs], 95 patients with benign pulmonary conditions [BPCs], 135 patients with other cancers [OCs], and 57 samples with interfering factors) were divided into a training cohort and a validation cohort according to 3 testing centers. The IDH1 concentrations in the NSCLC group were obviously higher than those in the control groups (P 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.14387