PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer

The identification of colorectal cancer (CRC) molecular targets is needed for the development of drugs that improve patient survival. We investigated the functional role of phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), a de novo purine...

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Veröffentlicht in:	Cancers 2020-03, Vol.12 (4), p.772
Hauptverfasser:	Agarwal, Sumit, Chakravarthi, Balabhadrapatruni V S K, Behring, Michael, Kim, Hyung-Gyoon, Chandrashekar, Darshan S, Gupta, Nirzari, Bajpai, Prachi, Elkholy, Amr, Balasubramanya, Sai A H, Hardy, Cherlene, Diffalha, Sameer Al, Varambally, Sooryanarayana, Manne, Upender
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biosynthesis Bone imaging Cancer Cancer therapies Cell adhesion & migration Cell culture Cell cycle Cell growth Cell proliferation Chemotherapy Colorectal cancer Colorectal carcinoma DNA biosynthesis Drug development Drug resistance E-cadherin Enzymes Gender Genes Hepatocytes Kinases Mesenchyme Metabolism Metabolites Metastases Metastasis MicroRNAs Myc protein p53 Protein Patients Phosphoribosylaminoimidazole carboxylase Positron emission tomography Protein expression Proteins Transcription
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