A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs
African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity,...
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| Veröffentlicht in: | Science China. Life sciences 2020, Vol.63 (5), p.623-634 |
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| container_title | Science China. Life sciences |
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| creator | Chen, Weiye Zhao, Dongming He, Xijun Liu, Renqiang Wang, Zilong Zhang, Xianfeng Li, Fang Shan, Dan Chen, Hefeng Zhang, Jiwen Wang, Lulu Wen, Zhiyuan Wang, Xijun Guan, Yuntao Liu, Jinxiong Bu, Zhigao |
| description | African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs, commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge. Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV, and as such is expected to play an important role in controlling the spread of ASFV. |
| doi_str_mv | 10.1007/s11427-020-1657-9 |
| format | Article |
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An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs, commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge. 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Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs, commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge. Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV, and as such is expected to play an important role in controlling the spread of ASFV.</description><subject>African swine fever</subject><subject>Asfarviridae</subject><subject>Biomedical and Life Sciences</subject><subject>Cover</subject><subject>Cover Article</subject><subject>Hogs</subject><subject>Immunogenicity</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Vaccines</subject><subject>Virulence</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkctKAzEUhoMoWrQP4EYCrqO5zOSyEUrxBoIbXYdM5kyN1LQmMyO-van1mk1OOF--hPMjdMzoGaNUnWfGKq4I5ZQwWStidtCEaWkI09rsllqqiihB6wM0zfmZliUE5UrtowPBGa-YphMUZjjDCJEsIAJpYQk9tHjWpeBdxPktRMBdARIeQxoyDhln1wF2scXQdeD7MJZTxg4vP6u-hzi4jWR03m-uh4jXYZGP0F7nlhmmX_shery6fJjfkLv769v57I6suah6opQyULEWagNSg9fGNV7XlOuu1Zo23hdMUi2E0dDIpmLQaWF4Y0RdMdGIQ3Sx9a6H5gVaD7FPbmnXKby49G5XLtj_nRie7GI1WsW5qI0sgtMvQVq9DpB7-7waUix_tlwYIcscpSnUyd9nfvzfoy0A3wK5tOIC0q-GUbuJ0G4jtCVCu4nQGvEBmaaMag</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Chen, Weiye</creator><creator>Zhao, Dongming</creator><creator>He, Xijun</creator><creator>Liu, Renqiang</creator><creator>Wang, Zilong</creator><creator>Zhang, Xianfeng</creator><creator>Li, Fang</creator><creator>Shan, Dan</creator><creator>Chen, Hefeng</creator><creator>Zhang, Jiwen</creator><creator>Wang, Lulu</creator><creator>Wen, Zhiyuan</creator><creator>Wang, Xijun</creator><creator>Guan, Yuntao</creator><creator>Liu, Jinxiong</creator><creator>Bu, Zhigao</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>2020</creationdate><title>A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs</title><author>Chen, Weiye ; Zhao, Dongming ; He, Xijun ; Liu, Renqiang ; Wang, Zilong ; Zhang, Xianfeng ; Li, Fang ; Shan, Dan ; Chen, Hefeng ; Zhang, Jiwen ; Wang, Lulu ; Wen, Zhiyuan ; Wang, Xijun ; Guan, Yuntao ; Liu, Jinxiong ; Bu, Zhigao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p234t-7779e41de59e68ec89abc85028fd880bcc2346083398eb6b41ef8392b935413b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>African swine fever</topic><topic>Asfarviridae</topic><topic>Biomedical and Life Sciences</topic><topic>Cover</topic><topic>Cover Article</topic><topic>Hogs</topic><topic>Immunogenicity</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><topic>Vaccines</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Weiye</creatorcontrib><creatorcontrib>Zhao, Dongming</creatorcontrib><creatorcontrib>He, Xijun</creatorcontrib><creatorcontrib>Liu, Renqiang</creatorcontrib><creatorcontrib>Wang, Zilong</creatorcontrib><creatorcontrib>Zhang, Xianfeng</creatorcontrib><creatorcontrib>Li, Fang</creatorcontrib><creatorcontrib>Shan, Dan</creatorcontrib><creatorcontrib>Chen, Hefeng</creatorcontrib><creatorcontrib>Zhang, Jiwen</creatorcontrib><creatorcontrib>Wang, Lulu</creatorcontrib><creatorcontrib>Wen, Zhiyuan</creatorcontrib><creatorcontrib>Wang, Xijun</creatorcontrib><creatorcontrib>Guan, Yuntao</creatorcontrib><creatorcontrib>Liu, Jinxiong</creatorcontrib><creatorcontrib>Bu, Zhigao</creatorcontrib><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science China. 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China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2020</date><risdate>2020</risdate><volume>63</volume><issue>5</issue><spage>623</spage><epage>634</epage><pages>623-634</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs, commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge. 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| subjects | African swine fever Asfarviridae Biomedical and Life Sciences Cover Cover Article Hogs Immunogenicity Infectious diseases Life Sciences Vaccines Virulence |
| title | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs |
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