Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine
Objective To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults. Design A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development. Methods The task force iden...
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| Veröffentlicht in: | Intensive care medicine 2020-04, Vol.46 (4), p.673-696 |
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| container_title | Intensive care medicine |
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| creator | Vlaar, Alexander P. Oczkowski, Simon de Bruin, Sanne Wijnberge, Marije Antonelli, Massimo Aubron, Cecile Aries, Philippe Duranteau, Jacques Juffermans, Nicole P. Meier, Jens Murphy, Gavin J. Abbasciano, Riccardo Muller, Marcella Shah, Akshay Perner, Anders Rygaard, Sofie Walsh, Timothy S. Guyatt, Gordon Dionne, J. C. Cecconi, Maurizio |
| description | Objective
To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.
Design
A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.
Methods
The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.
Results
The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any recommendation.
Conclusions
This clinical practice guideline provides evidence-based recommendations and identifies areas where further research is needed regarding transfusion practices and transfusion avoidance in non-bleeding, critically ill adults. |
| doi_str_mv | 10.1007/s00134-019-05884-8 |
| format | Article |
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To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.
Design
A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.
Methods
The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.
Results
The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any recommendation.
Conclusions
This clinical practice guideline provides evidence-based recommendations and identifies areas where further research is needed regarding transfusion practices and transfusion avoidance in non-bleeding, critically ill adults.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-019-05884-8</identifier><identifier>PMID: 31912207</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Adults ; Anesthesiology ; Avoidance ; Bleeding ; Blood Component Transfusion ; Blood platelets ; Blood Transfusion ; Clinical medicine ; Clinical practice guidelines ; Conference Reports and Expert Panel ; Critical Care ; Critical Care Medicine ; Critical Illness - therapy ; Emergency Medicine ; Erythrocytes ; Evidence-based medicine ; Humans ; Identification methods ; Intensive ; Intensive care ; Medicine ; Medicine & Public Health ; Pain Medicine ; Pediatrics ; Plasma ; Pneumology/Respiratory System ; Task forces ; Transfusion</subject><ispartof>Intensive care medicine, 2020-04, Vol.46 (4), p.673-696</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Intensive Care Medicine is a copyright of Springer, (2020). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-b4179e548f79f7c43e2f3fbdacf76b31a91834bf19837315842772343a9fe3753</citedby><cites>FETCH-LOGICAL-c579t-b4179e548f79f7c43e2f3fbdacf76b31a91834bf19837315842772343a9fe3753</cites><orcidid>0000-0002-3453-7186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00134-019-05884-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00134-019-05884-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31912207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vlaar, Alexander P.</creatorcontrib><creatorcontrib>Oczkowski, Simon</creatorcontrib><creatorcontrib>de Bruin, Sanne</creatorcontrib><creatorcontrib>Wijnberge, Marije</creatorcontrib><creatorcontrib>Antonelli, Massimo</creatorcontrib><creatorcontrib>Aubron, Cecile</creatorcontrib><creatorcontrib>Aries, Philippe</creatorcontrib><creatorcontrib>Duranteau, Jacques</creatorcontrib><creatorcontrib>Juffermans, Nicole P.</creatorcontrib><creatorcontrib>Meier, Jens</creatorcontrib><creatorcontrib>Murphy, Gavin J.</creatorcontrib><creatorcontrib>Abbasciano, Riccardo</creatorcontrib><creatorcontrib>Muller, Marcella</creatorcontrib><creatorcontrib>Shah, Akshay</creatorcontrib><creatorcontrib>Perner, Anders</creatorcontrib><creatorcontrib>Rygaard, Sofie</creatorcontrib><creatorcontrib>Walsh, Timothy S.</creatorcontrib><creatorcontrib>Guyatt, Gordon</creatorcontrib><creatorcontrib>Dionne, J. C.</creatorcontrib><creatorcontrib>Cecconi, Maurizio</creatorcontrib><title>Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><addtitle>Intensive Care Med</addtitle><description>Objective
To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.
Design
A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.
Methods
The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.
Results
The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any recommendation.
Conclusions
This clinical practice guideline provides evidence-based recommendations and identifies areas where further research is needed regarding transfusion practices and transfusion avoidance in non-bleeding, critically ill adults.</description><subject>Adult</subject><subject>Adults</subject><subject>Anesthesiology</subject><subject>Avoidance</subject><subject>Bleeding</subject><subject>Blood Component Transfusion</subject><subject>Blood platelets</subject><subject>Blood Transfusion</subject><subject>Clinical medicine</subject><subject>Clinical practice guidelines</subject><subject>Conference Reports and Expert Panel</subject><subject>Critical Care</subject><subject>Critical Care Medicine</subject><subject>Critical Illness - therapy</subject><subject>Emergency Medicine</subject><subject>Erythrocytes</subject><subject>Evidence-based medicine</subject><subject>Humans</subject><subject>Identification methods</subject><subject>Intensive</subject><subject>Intensive care</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pain Medicine</subject><subject>Pediatrics</subject><subject>Plasma</subject><subject>Pneumology/Respiratory System</subject><subject>Task forces</subject><subject>Transfusion</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kt9qFDEUxgdR7Fp9AS8k4E1vUvNvNhkvhLJULVS8sF6HTOZkmpJN1mSmsG_hI5t1a2tlkVwEzvl9X3IOX9O8puSUEiLfFUIoF5jQDpNWKYHVk2ZBBWeYMq6eNgvCBcNiKdhR86KUm4rLZUufN0ecdpQxIhfNz6tsYnFz8SmiMmUzweihIB9RTBH3AWDwcUQ2-8lbE8IW-RCQGeYwlffIIBt83DXQJhtbEUDj7AeoVUAupzWargGdzzltwET0LVkP0xYlhy7iBLH4W0ArkwF9qe_YKnrZPHMmFHh1dx833z-eX60-48uvny5WZ5fYtrKbcC-o7KAVysnOSSs4MMddPxjr5LLn1HRUcdE72ikuOW2VYFIyLrjpHHDZ8uPmw953M_drGCzEOnzQm-zXJm91Ml4_7kR_rcd0qyXb2fBqcHJnkNOPGcqk175YCMFESHPRjHMhSd35sqJv_0Fv0pxjHa9SiiupCBMP1GgCaB9dqu_anak-q1_vmGSUVAofoEaIUD-ZIjhfy4_40wN8PQOsvT0oYHuBzamUDO5-J5ToXe70Pne65k7_zp1WVfTm723eS_4ErQJ8D5TaiiPkhxX8x_YXgG7jZw</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Vlaar, Alexander P.</creator><creator>Oczkowski, Simon</creator><creator>de Bruin, Sanne</creator><creator>Wijnberge, Marije</creator><creator>Antonelli, Massimo</creator><creator>Aubron, Cecile</creator><creator>Aries, Philippe</creator><creator>Duranteau, Jacques</creator><creator>Juffermans, Nicole P.</creator><creator>Meier, Jens</creator><creator>Murphy, Gavin J.</creator><creator>Abbasciano, Riccardo</creator><creator>Muller, Marcella</creator><creator>Shah, Akshay</creator><creator>Perner, Anders</creator><creator>Rygaard, Sofie</creator><creator>Walsh, Timothy S.</creator><creator>Guyatt, Gordon</creator><creator>Dionne, J. C.</creator><creator>Cecconi, Maurizio</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3453-7186</orcidid></search><sort><creationdate>20200401</creationdate><title>Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine</title><author>Vlaar, Alexander P. ; Oczkowski, Simon ; de Bruin, Sanne ; Wijnberge, Marije ; Antonelli, Massimo ; Aubron, Cecile ; Aries, Philippe ; Duranteau, Jacques ; Juffermans, Nicole P. ; Meier, Jens ; Murphy, Gavin J. ; Abbasciano, Riccardo ; Muller, Marcella ; Shah, Akshay ; Perner, Anders ; Rygaard, Sofie ; Walsh, Timothy S. ; Guyatt, Gordon ; Dionne, J. C. ; Cecconi, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-b4179e548f79f7c43e2f3fbdacf76b31a91834bf19837315842772343a9fe3753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Anesthesiology</topic><topic>Avoidance</topic><topic>Bleeding</topic><topic>Blood Component Transfusion</topic><topic>Blood platelets</topic><topic>Blood Transfusion</topic><topic>Clinical medicine</topic><topic>Clinical practice guidelines</topic><topic>Conference Reports and Expert Panel</topic><topic>Critical Care</topic><topic>Critical Care Medicine</topic><topic>Critical Illness - therapy</topic><topic>Emergency Medicine</topic><topic>Erythrocytes</topic><topic>Evidence-based medicine</topic><topic>Humans</topic><topic>Identification methods</topic><topic>Intensive</topic><topic>Intensive care</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pain Medicine</topic><topic>Pediatrics</topic><topic>Plasma</topic><topic>Pneumology/Respiratory System</topic><topic>Task forces</topic><topic>Transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vlaar, Alexander P.</creatorcontrib><creatorcontrib>Oczkowski, Simon</creatorcontrib><creatorcontrib>de Bruin, Sanne</creatorcontrib><creatorcontrib>Wijnberge, Marije</creatorcontrib><creatorcontrib>Antonelli, Massimo</creatorcontrib><creatorcontrib>Aubron, Cecile</creatorcontrib><creatorcontrib>Aries, Philippe</creatorcontrib><creatorcontrib>Duranteau, Jacques</creatorcontrib><creatorcontrib>Juffermans, Nicole P.</creatorcontrib><creatorcontrib>Meier, Jens</creatorcontrib><creatorcontrib>Murphy, Gavin J.</creatorcontrib><creatorcontrib>Abbasciano, Riccardo</creatorcontrib><creatorcontrib>Muller, Marcella</creatorcontrib><creatorcontrib>Shah, Akshay</creatorcontrib><creatorcontrib>Perner, Anders</creatorcontrib><creatorcontrib>Rygaard, Sofie</creatorcontrib><creatorcontrib>Walsh, Timothy S.</creatorcontrib><creatorcontrib>Guyatt, Gordon</creatorcontrib><creatorcontrib>Dionne, J. C.</creatorcontrib><creatorcontrib>Cecconi, Maurizio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vlaar, Alexander P.</au><au>Oczkowski, Simon</au><au>de Bruin, Sanne</au><au>Wijnberge, Marije</au><au>Antonelli, Massimo</au><au>Aubron, Cecile</au><au>Aries, Philippe</au><au>Duranteau, Jacques</au><au>Juffermans, Nicole P.</au><au>Meier, Jens</au><au>Murphy, Gavin J.</au><au>Abbasciano, Riccardo</au><au>Muller, Marcella</au><au>Shah, Akshay</au><au>Perner, Anders</au><au>Rygaard, Sofie</au><au>Walsh, Timothy S.</au><au>Guyatt, Gordon</au><au>Dionne, J. C.</au><au>Cecconi, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine</atitle><jtitle>Intensive care medicine</jtitle><stitle>Intensive Care Med</stitle><addtitle>Intensive Care Med</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>46</volume><issue>4</issue><spage>673</spage><epage>696</epage><pages>673-696</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><abstract>Objective
To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.
Design
A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.
Methods
The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.
Results
The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any recommendation.
Conclusions
This clinical practice guideline provides evidence-based recommendations and identifies areas where further research is needed regarding transfusion practices and transfusion avoidance in non-bleeding, critically ill adults.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31912207</pmid><doi>10.1007/s00134-019-05884-8</doi><tpages>24</tpages><orcidid>https://orcid.org/0000-0002-3453-7186</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0342-4642 |
| ispartof | Intensive care medicine, 2020-04, Vol.46 (4), p.673-696 |
| issn | 0342-4642 1432-1238 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7223433 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Adults Anesthesiology Avoidance Bleeding Blood Component Transfusion Blood platelets Blood Transfusion Clinical medicine Clinical practice guidelines Conference Reports and Expert Panel Critical Care Critical Care Medicine Critical Illness - therapy Emergency Medicine Erythrocytes Evidence-based medicine Humans Identification methods Intensive Intensive care Medicine Medicine & Public Health Pain Medicine Pediatrics Plasma Pneumology/Respiratory System Task forces Transfusion |
| title | Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine |
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