Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma

Background Activation of Wnt/β-catenin pathway is a frequent event in hepatocellular carcinoma and is associated with enhanced cell survival and proliferation. Therefore, targeting this signaling pathway is discussed as an attractive therapeutic approach for HCC treatment. BCL9 and BCL9L, two homolo...

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Veröffentlicht in:	Hepatology international 2020-05, Vol.14 (3), p.373-384
Hauptverfasser:	Huge, Nicole, Sandbothe, Maria, Schröder, Anna K., Stalke, Amelie, Eilers, Marlies, Schäffer, Vera, Schlegelberger, Brigitte, Illig, Thomas, Vajen, Beate, Skawran, Britta
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis beta Catenin - metabolism Biotechnology Cancer Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation Cell Survival Cell viability Colorectal Surgery DNA-Binding Proteins - genetics Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Hepatocytes Hepatology Homology Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Medicine Medicine & Public Health Neoplasm Proteins Original Original Article Pharmacogenetics Prognosis Signal transduction Signaling siRNA Surgery Survival Survival Analysis Transcription Factors - genetics Tumors Wnt protein Wnt Signaling Pathway β-Catenin
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