Favorable retention rates and safety of conventional anti-rheumatic drugs in older patients with rheumatoid arthritis
Physicians are challenged by the recognition and treatment of older patients with rheumatoid arthritis (RA). The aim of this case-control study was to evaluate the retention and safety of conventional disease-modifying anti-rheumatic drugs in older patients with RA.In this observational case-control...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-04, Vol.99 (16), p.e19696-e19696 |
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| creator | Alpay-Kanitez, Nilüfer Pehlivan, Özlem Omma, Ahmet Can-Sandikçi, Sevinç Girgin, Sinem İçaçan, Ozan Cemal Çelik, Selda Bes, Cemal |
| description | Physicians are challenged by the recognition and treatment of older patients with rheumatoid arthritis (RA). The aim of this case-control study was to evaluate the retention and safety of conventional disease-modifying anti-rheumatic drugs in older patients with RA.In this observational case-control study, we assessed older patients with RA (≥65 years) who were diagnosed in 3 different rheumatology centers from Turkey. Patients were divided as to those aged ≥65 years (elderly rheumatoid arthritis [ERA]) and those aged |
| doi_str_mv | 10.1097/MD.0000000000019696 |
| format | Article |
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The aim of this case-control study was to evaluate the retention and safety of conventional disease-modifying anti-rheumatic drugs in older patients with RA.In this observational case-control study, we assessed older patients with RA (≥65 years) who were diagnosed in 3 different rheumatology centers from Turkey. Patients were divided as to those aged ≥65 years (elderly rheumatoid arthritis [ERA]) and those aged <65 years (young rheumatoid arthritis [YRA]) at the time of conventional DMARD treatment initiation. The Mann-Whitney U test was used for the comparison of 2 non-normally distributed groups. The Chi-square (χ) test was used for categorical variables. Survival analysis were performed using the Kaplan-Meier method.Four hundred eighteen patients with RA (296 females [71%]) were included from January 2010 to January 2018. The age of treatment onset of 190 (47%) patients was in the elderly period and they were included in the ERA group. In the analysis of drug retention rates, there was no significant difference between the ERA and YRA groups for each conventional DMARD (methotrexate 71.2% in ERA, 62.7% in YRA, P = .817; hydroxychloroquine 82.9% in ERA, 78.8% in YRA, P = .899; leflunomide 81.4% in ERA, 84.4% in YRA, P = .205; sulfasalazine 37.5% in ERA, 40.9% in YRA, P = .380). The adverse event data were also similar in both groups.The drug retention and adverse effect rates in older patients with RA using conventional DMARDS are similar to the rates in young patients with RA.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000019696</identifier><identifier>PMID: 32311948</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Age Factors ; Aged ; Antirheumatic Agents - adverse effects ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - drug therapy ; Case-Control Studies ; Female ; Humans ; Male ; Medication Adherence ; Middle Aged ; Observational Study ; Patient Safety ; Retrospective Studies</subject><ispartof>Medicine (Baltimore), 2020-04, Vol.99 (16), p.e19696-e19696</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4502-20311f5b3c282adc670d90ca50f222f9f5925bdf6d4c4d27f0aa24141d14b8f03</citedby><cites>FETCH-LOGICAL-c4502-20311f5b3c282adc670d90ca50f222f9f5925bdf6d4c4d27f0aa24141d14b8f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220761/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220761/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32311948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alpay-Kanitez, Nilüfer</creatorcontrib><creatorcontrib>Pehlivan, Özlem</creatorcontrib><creatorcontrib>Omma, Ahmet</creatorcontrib><creatorcontrib>Can-Sandikçi, Sevinç</creatorcontrib><creatorcontrib>Girgin, Sinem</creatorcontrib><creatorcontrib>İçaçan, Ozan Cemal</creatorcontrib><creatorcontrib>Çelik, Selda</creatorcontrib><creatorcontrib>Bes, Cemal</creatorcontrib><title>Favorable retention rates and safety of conventional anti-rheumatic drugs in older patients with rheumatoid arthritis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Physicians are challenged by the recognition and treatment of older patients with rheumatoid arthritis (RA). The aim of this case-control study was to evaluate the retention and safety of conventional disease-modifying anti-rheumatic drugs in older patients with RA.In this observational case-control study, we assessed older patients with RA (≥65 years) who were diagnosed in 3 different rheumatology centers from Turkey. Patients were divided as to those aged ≥65 years (elderly rheumatoid arthritis [ERA]) and those aged <65 years (young rheumatoid arthritis [YRA]) at the time of conventional DMARD treatment initiation. The Mann-Whitney U test was used for the comparison of 2 non-normally distributed groups. The Chi-square (χ) test was used for categorical variables. Survival analysis were performed using the Kaplan-Meier method.Four hundred eighteen patients with RA (296 females [71%]) were included from January 2010 to January 2018. The age of treatment onset of 190 (47%) patients was in the elderly period and they were included in the ERA group. In the analysis of drug retention rates, there was no significant difference between the ERA and YRA groups for each conventional DMARD (methotrexate 71.2% in ERA, 62.7% in YRA, P = .817; hydroxychloroquine 82.9% in ERA, 78.8% in YRA, P = .899; leflunomide 81.4% in ERA, 84.4% in YRA, P = .205; sulfasalazine 37.5% in ERA, 40.9% in YRA, P = .380). The adverse event data were also similar in both groups.The drug retention and adverse effect rates in older patients with RA using conventional DMARDS are similar to the rates in young patients with RA.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Antirheumatic Agents - adverse effects</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medication Adherence</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Patient Safety</subject><subject>Retrospective Studies</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctuHCEQRVGUKB7b-YJIFj_QdkFDM2wsRXb8kGxlY68RzcNN0tOMgJ6R_z4442fYINU991ZBIfSdwDEBKU5uz4_h7RDZye4TWhDedg2XHfuMFgCUN0IKtof2c_5doVZQ9hXttbQlRLLlAs0XehOT7keHkytuKiFOOOniMtaTxVl7Vx5x9NjEabOT9VilEpo0uHmlSzDYpvkh4zDhOFqX8LoWK5rxNpQBP2MxWKxTGVIoIR-iL16P2X17vg_Q_cXPu7Or5ubX5fXZj5vGMA60oVDH9LxvDV1SbU0nwEowmoOnlHrpuaS8t76zzDBLhQetKSOMWML6pYf2AJ3uctdzv3LW1KmSHtU6hZVOjyrqoD4qUxjUQ9woQSmIjtSAdhdgUsw5Of_qJaCetqBuz9X_W6iuo_dtXz0v314BtgO2cSwu5T_jvHVJDU6PZfiXx4V8ej8FYERAUyvV_BevjJYd</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Alpay-Kanitez, Nilüfer</creator><creator>Pehlivan, Özlem</creator><creator>Omma, Ahmet</creator><creator>Can-Sandikçi, Sevinç</creator><creator>Girgin, Sinem</creator><creator>İçaçan, Ozan Cemal</creator><creator>Çelik, Selda</creator><creator>Bes, Cemal</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>Favorable retention rates and safety of conventional anti-rheumatic drugs in older patients with rheumatoid arthritis</title><author>Alpay-Kanitez, Nilüfer ; Pehlivan, Özlem ; Omma, Ahmet ; Can-Sandikçi, Sevinç ; Girgin, Sinem ; İçaçan, Ozan Cemal ; Çelik, Selda ; Bes, Cemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4502-20311f5b3c282adc670d90ca50f222f9f5925bdf6d4c4d27f0aa24141d14b8f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Antirheumatic Agents - adverse effects</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medication Adherence</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Patient Safety</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alpay-Kanitez, Nilüfer</creatorcontrib><creatorcontrib>Pehlivan, Özlem</creatorcontrib><creatorcontrib>Omma, Ahmet</creatorcontrib><creatorcontrib>Can-Sandikçi, Sevinç</creatorcontrib><creatorcontrib>Girgin, Sinem</creatorcontrib><creatorcontrib>İçaçan, Ozan Cemal</creatorcontrib><creatorcontrib>Çelik, Selda</creatorcontrib><creatorcontrib>Bes, Cemal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alpay-Kanitez, Nilüfer</au><au>Pehlivan, Özlem</au><au>Omma, Ahmet</au><au>Can-Sandikçi, Sevinç</au><au>Girgin, Sinem</au><au>İçaçan, Ozan Cemal</au><au>Çelik, Selda</au><au>Bes, Cemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Favorable retention rates and safety of conventional anti-rheumatic drugs in older patients with rheumatoid arthritis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>99</volume><issue>16</issue><spage>e19696</spage><epage>e19696</epage><pages>e19696-e19696</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Physicians are challenged by the recognition and treatment of older patients with rheumatoid arthritis (RA). The aim of this case-control study was to evaluate the retention and safety of conventional disease-modifying anti-rheumatic drugs in older patients with RA.In this observational case-control study, we assessed older patients with RA (≥65 years) who were diagnosed in 3 different rheumatology centers from Turkey. Patients were divided as to those aged ≥65 years (elderly rheumatoid arthritis [ERA]) and those aged <65 years (young rheumatoid arthritis [YRA]) at the time of conventional DMARD treatment initiation. The Mann-Whitney U test was used for the comparison of 2 non-normally distributed groups. The Chi-square (χ) test was used for categorical variables. Survival analysis were performed using the Kaplan-Meier method.Four hundred eighteen patients with RA (296 females [71%]) were included from January 2010 to January 2018. The age of treatment onset of 190 (47%) patients was in the elderly period and they were included in the ERA group. In the analysis of drug retention rates, there was no significant difference between the ERA and YRA groups for each conventional DMARD (methotrexate 71.2% in ERA, 62.7% in YRA, P = .817; hydroxychloroquine 82.9% in ERA, 78.8% in YRA, P = .899; leflunomide 81.4% in ERA, 84.4% in YRA, P = .205; sulfasalazine 37.5% in ERA, 40.9% in YRA, P = .380). The adverse event data were also similar in both groups.The drug retention and adverse effect rates in older patients with RA using conventional DMARDS are similar to the rates in young patients with RA.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>32311948</pmid><doi>10.1097/MD.0000000000019696</doi><oa>free_for_read</oa></addata></record> |
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| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Age Factors Aged Antirheumatic Agents - adverse effects Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Case-Control Studies Female Humans Male Medication Adherence Middle Aged Observational Study Patient Safety Retrospective Studies |
| title | Favorable retention rates and safety of conventional anti-rheumatic drugs in older patients with rheumatoid arthritis |
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