Multiple versus single doses of dexamethasone in total hip arthroplasty: A protocol of randomized controlled trial
Reduction of post-operative pain, nausea, and vomiting in patients undergoing total hip arthroplasty (THA) may facilitate earlier discharge from hospital and reduce healthcare costs. The recommended dose regimen of dexamethasone in THA has not been determined. The purpose of this study was performed...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-05, Vol.99 (19), p.e20147-e20147 |
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| creator | Zhang, Bangjian Sun, Shaoqiong Sheng, Bo |
| description | Reduction of post-operative pain, nausea, and vomiting in patients undergoing total hip arthroplasty (THA) may facilitate earlier discharge from hospital and reduce healthcare costs. The recommended dose regimen of dexamethasone in THA has not been determined. The purpose of this study was performed to compare the efficiency of multiple versus single doses of dexamethasone for early postoperative pain treatment after THA.
This study was a randomized controlled trial which conducted in our hospital. Informed consent for participation in this trial was obtained from each patient before surgery. Two hundred patients undergoing THA received 1 dose of intravenous dexamethasone and 1 dose of normal saline (Group A), or 2 doses of intravenous dexamethasone (Group B). The primary outcome was visual analog scale pain scores in the immediate postoperative period. Secondary outcomes included postoperative opioid use, length of hospital stay, activity level during physical therapy, and hip range of motion.
This clinical trial might provide some insights to estimate the safety of dexamethasone.
This study protocol was registered in Research Registry (researchregistry5460). |
| doi_str_mv | 10.1097/MD.0000000000020147 |
| format | Article |
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This study was a randomized controlled trial which conducted in our hospital. Informed consent for participation in this trial was obtained from each patient before surgery. Two hundred patients undergoing THA received 1 dose of intravenous dexamethasone and 1 dose of normal saline (Group A), or 2 doses of intravenous dexamethasone (Group B). The primary outcome was visual analog scale pain scores in the immediate postoperative period. Secondary outcomes included postoperative opioid use, length of hospital stay, activity level during physical therapy, and hip range of motion.
This clinical trial might provide some insights to estimate the safety of dexamethasone.
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This study was a randomized controlled trial which conducted in our hospital. Informed consent for participation in this trial was obtained from each patient before surgery. Two hundred patients undergoing THA received 1 dose of intravenous dexamethasone and 1 dose of normal saline (Group A), or 2 doses of intravenous dexamethasone (Group B). The primary outcome was visual analog scale pain scores in the immediate postoperative period. Secondary outcomes included postoperative opioid use, length of hospital stay, activity level during physical therapy, and hip range of motion.
This clinical trial might provide some insights to estimate the safety of dexamethasone.
This study protocol was registered in Research Registry (researchregistry5460).</description><subject>Administration, Intravenous</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Arthroplasty, Replacement, Hip - methods</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Prospective Studies</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Range of Motion, Articular</subject><subject>Study Protocol Clinical Trial</subject><subject>Young Adult</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctu1TAQtRCIXgpfgIS8ZJMyju04lwVS1fKo1KtuytqaxJNeIycOtlO1_XpStZTHbOZ5zhzpMPZWwJGArfmwOz2CP1GDUOYZ2wgtm0pvG_WcbdaprszWqAP2KucfAEKaWr1kB7KWrdIAG5Z2Syh-DsSvKeUl8-ynq7VzMVPmceCObnCkssccJ-J-4iUWDHzvZ46p7FOcA-Zy-5Ef8znFEvsY7mEJJxdHf0eO93EqKYawliV5DK_ZiwFDpjeP-ZB9__L58uRbdX7x9ezk-LzqpYBSta6jwTnCTjsEAT2020FRR3Kg2nQdSteiEohd35DsUGsgLVptGklS1k4esk8PvPPSjeR6WmVgsHPyI6ZbG9HbfzeT39ureG1NXYNq5Erw_pEgxZ8L5WJHn3sKASeKS7a1AtBaCDDrqXw47VPMOdHw9EaAvXfL7k7t_26tqHd_K3zC_LZH_gKIyZSN</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Zhang, Bangjian</creator><creator>Sun, Shaoqiong</creator><creator>Sheng, Bo</creator><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7855-8704</orcidid></search><sort><creationdate>20200501</creationdate><title>Multiple versus single doses of dexamethasone in total hip arthroplasty: A protocol of randomized controlled trial</title><author>Zhang, Bangjian ; Sun, Shaoqiong ; Sheng, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-8dbefddeab5da010c089f4ebe3fe27bba3d8a41aabc6e3ba550e5185763e332d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Intravenous</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Arthroplasty, Replacement, Hip - methods</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pain Measurement</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Prospective Studies</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Range of Motion, Articular</topic><topic>Study Protocol Clinical Trial</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Bangjian</creatorcontrib><creatorcontrib>Sun, Shaoqiong</creatorcontrib><creatorcontrib>Sheng, Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Bangjian</au><au>Sun, Shaoqiong</au><au>Sheng, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple versus single doses of dexamethasone in total hip arthroplasty: A protocol of randomized controlled trial</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>99</volume><issue>19</issue><spage>e20147</spage><epage>e20147</epage><pages>e20147-e20147</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Reduction of post-operative pain, nausea, and vomiting in patients undergoing total hip arthroplasty (THA) may facilitate earlier discharge from hospital and reduce healthcare costs. The recommended dose regimen of dexamethasone in THA has not been determined. The purpose of this study was performed to compare the efficiency of multiple versus single doses of dexamethasone for early postoperative pain treatment after THA.
This study was a randomized controlled trial which conducted in our hospital. Informed consent for participation in this trial was obtained from each patient before surgery. Two hundred patients undergoing THA received 1 dose of intravenous dexamethasone and 1 dose of normal saline (Group A), or 2 doses of intravenous dexamethasone (Group B). The primary outcome was visual analog scale pain scores in the immediate postoperative period. Secondary outcomes included postoperative opioid use, length of hospital stay, activity level during physical therapy, and hip range of motion.
This clinical trial might provide some insights to estimate the safety of dexamethasone.
This study protocol was registered in Research Registry (researchregistry5460).</abstract><cop>United States</cop><pub>Wolters Kluwer Health</pub><pmid>32384500</pmid><doi>10.1097/MD.0000000000020147</doi><orcidid>https://orcid.org/0000-0002-7855-8704</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Administration, Intravenous Adolescent Adult Aged Aged, 80 and over Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Arthroplasty, Replacement, Hip - methods Dexamethasone - administration & dosage Dexamethasone - therapeutic use Double-Blind Method Drug Administration Schedule Female Humans Length of Stay Male Middle Aged Pain Measurement Pain, Postoperative - drug therapy Prospective Studies Randomized Controlled Trials as Topic Range of Motion, Articular Study Protocol Clinical Trial Young Adult |
| title | Multiple versus single doses of dexamethasone in total hip arthroplasty: A protocol of randomized controlled trial |
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