The association between HHEX single-nucleotide polymorphism rs5015480 and gestational diabetes mellitus: A meta-analysis
To evaluate the association between the rs5015480 single-nucleotide polymorphism of hematopoietically expressed homeobox (HHEX) and gestational diabetes mellitus (GDM) via meta-analysis. A comprehensive electronic search was performed of the PubMed, Springer, Science Direct, China National Knowledge...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-03, Vol.99 (12), p.e19478-e19478 |
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| creator | Wang, Xingjie Ding, Yuanlin Zhang, Xinshan Rao, Jiawei Yu, Haibin Pan, Haiyan |
| description | To evaluate the association between the rs5015480 single-nucleotide polymorphism of hematopoietically expressed homeobox (HHEX) and gestational diabetes mellitus (GDM) via meta-analysis.
A comprehensive electronic search was performed of the PubMed, Springer, Science Direct, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for studies worldwide on the relationship between HHEX rs5015480 and GDM published up to July 2019. Rigorous inclusion and exclusion criteria were developed, and the quality of studies was assessed using the Newcastle-Ottawa scale, followed by heterogeneity evaluation using the Q test and I statistic and data pooling. A meta-analysis was then performed on the included studies using RevMan 5.3.
A total of 4 eligible case-control studies were included, involving a total of 1651 patients and 3513 controls. The meta-analysis showed the following odds ratios: C allele vs T allele, 1.24 (95% confidence interval [CI]: 1.12-1.38); CC genotype vs TT genotype, 1.65 (95% CI: 1.26-2.17); CC genotype vs CT genotype, 1.22 (95% CI: 1.00-1.50); and CC genotype vs CT + TT genotype, 1.32 (95% CI: 1.09-1.61).
HHEX rs5015480 represents a risk factor for the development of GDM, and pregnant women carrying the CC genotype have an increased risk of GDM. |
| doi_str_mv | 10.1097/MD.0000000000019478 |
| format | Article |
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A comprehensive electronic search was performed of the PubMed, Springer, Science Direct, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for studies worldwide on the relationship between HHEX rs5015480 and GDM published up to July 2019. Rigorous inclusion and exclusion criteria were developed, and the quality of studies was assessed using the Newcastle-Ottawa scale, followed by heterogeneity evaluation using the Q test and I statistic and data pooling. A meta-analysis was then performed on the included studies using RevMan 5.3.
A total of 4 eligible case-control studies were included, involving a total of 1651 patients and 3513 controls. The meta-analysis showed the following odds ratios: C allele vs T allele, 1.24 (95% confidence interval [CI]: 1.12-1.38); CC genotype vs TT genotype, 1.65 (95% CI: 1.26-2.17); CC genotype vs CT genotype, 1.22 (95% CI: 1.00-1.50); and CC genotype vs CT + TT genotype, 1.32 (95% CI: 1.09-1.61).
HHEX rs5015480 represents a risk factor for the development of GDM, and pregnant women carrying the CC genotype have an increased risk of GDM.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000019478</identifier><identifier>PMID: 32195947</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Alleles ; Case-Control Studies ; Diabetes, Gestational - epidemiology ; Diabetes, Gestational - genetics ; Evidence-Based Medicine ; Female ; Genotype ; Homeodomain Proteins - genetics ; Humans ; Polymorphism, Single Nucleotide - genetics ; Pregnancy ; Risk Factors ; Systematic Review and Meta-Analysis ; Transcription Factors - genetics</subject><ispartof>Medicine (Baltimore), 2020-03, Vol.99 (12), p.e19478-e19478</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3555-f8c6b8a01e9705bc16e2c6202b9ff1066ccbf25eacd72ce339fe1716d31423bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220328/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220328/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32195947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xingjie</creatorcontrib><creatorcontrib>Ding, Yuanlin</creatorcontrib><creatorcontrib>Zhang, Xinshan</creatorcontrib><creatorcontrib>Rao, Jiawei</creatorcontrib><creatorcontrib>Yu, Haibin</creatorcontrib><creatorcontrib>Pan, Haiyan</creatorcontrib><title>The association between HHEX single-nucleotide polymorphism rs5015480 and gestational diabetes mellitus: A meta-analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To evaluate the association between the rs5015480 single-nucleotide polymorphism of hematopoietically expressed homeobox (HHEX) and gestational diabetes mellitus (GDM) via meta-analysis.
A comprehensive electronic search was performed of the PubMed, Springer, Science Direct, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for studies worldwide on the relationship between HHEX rs5015480 and GDM published up to July 2019. Rigorous inclusion and exclusion criteria were developed, and the quality of studies was assessed using the Newcastle-Ottawa scale, followed by heterogeneity evaluation using the Q test and I statistic and data pooling. A meta-analysis was then performed on the included studies using RevMan 5.3.
A total of 4 eligible case-control studies were included, involving a total of 1651 patients and 3513 controls. The meta-analysis showed the following odds ratios: C allele vs T allele, 1.24 (95% confidence interval [CI]: 1.12-1.38); CC genotype vs TT genotype, 1.65 (95% CI: 1.26-2.17); CC genotype vs CT genotype, 1.22 (95% CI: 1.00-1.50); and CC genotype vs CT + TT genotype, 1.32 (95% CI: 1.09-1.61).
HHEX rs5015480 represents a risk factor for the development of GDM, and pregnant women carrying the CC genotype have an increased risk of GDM.</description><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Diabetes, Gestational - epidemiology</subject><subject>Diabetes, Gestational - genetics</subject><subject>Evidence-Based Medicine</subject><subject>Female</subject><subject>Genotype</subject><subject>Homeodomain Proteins - genetics</subject><subject>Humans</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>Systematic Review and Meta-Analysis</subject><subject>Transcription Factors - genetics</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAUhS0EotPCL0BCXrJJ8SOOYxZIVVs6SK3YFImd5Tg3E4MTD7bDMP8et1PKwxtbuud-91wfhF5RckqJkm9vLk7Jn0NVLdsnaEUFbyqhmvopWhHCRCWVrI_QcUpfi4hLVj9HR5xRJUrDCv28HQGblIJ1Jrsw4w7yDmDG6_XlF5zcvPFQzYv1ELLrAW-D308hbkeXJhyTIFTULcFm7vEGUr5nGI97ZwoIEp7Ae5eX9A6flXc2lSnlfXLpBXo2GJ_g5cN9gj5_uLw9X1fXn64-np9dV5YLIaqhtU3XGkJBSSI6SxtgtmGEdWoYKGkaa7uBCTC2l8wC52oAKmnTc1oz3ll-gt4fuNulm6C3MOdovN5GN5m418E4_W9ldqPehB9aMkY4awvgzQMghu9L2VFPLtmylpkhLEkz3tJiSCpSpPwgtTGkFGF4HEOJvstM31zo_zMrXa__dvjY8zukIqgPgl3wGWL65pcdRD2C8Xm85wmpWFU-hRTHhFTkLnj-C8ZCo54</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Wang, Xingjie</creator><creator>Ding, Yuanlin</creator><creator>Zhang, Xinshan</creator><creator>Rao, Jiawei</creator><creator>Yu, Haibin</creator><creator>Pan, Haiyan</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200301</creationdate><title>The association between HHEX single-nucleotide polymorphism rs5015480 and gestational diabetes mellitus: A meta-analysis</title><author>Wang, Xingjie ; Ding, Yuanlin ; Zhang, Xinshan ; Rao, Jiawei ; Yu, Haibin ; Pan, Haiyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3555-f8c6b8a01e9705bc16e2c6202b9ff1066ccbf25eacd72ce339fe1716d31423bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Diabetes, Gestational - epidemiology</topic><topic>Diabetes, Gestational - genetics</topic><topic>Evidence-Based Medicine</topic><topic>Female</topic><topic>Genotype</topic><topic>Homeodomain Proteins - genetics</topic><topic>Humans</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>Systematic Review and Meta-Analysis</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xingjie</creatorcontrib><creatorcontrib>Ding, Yuanlin</creatorcontrib><creatorcontrib>Zhang, Xinshan</creatorcontrib><creatorcontrib>Rao, Jiawei</creatorcontrib><creatorcontrib>Yu, Haibin</creatorcontrib><creatorcontrib>Pan, Haiyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xingjie</au><au>Ding, Yuanlin</au><au>Zhang, Xinshan</au><au>Rao, Jiawei</au><au>Yu, Haibin</au><au>Pan, Haiyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between HHEX single-nucleotide polymorphism rs5015480 and gestational diabetes mellitus: A meta-analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>99</volume><issue>12</issue><spage>e19478</spage><epage>e19478</epage><pages>e19478-e19478</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>To evaluate the association between the rs5015480 single-nucleotide polymorphism of hematopoietically expressed homeobox (HHEX) and gestational diabetes mellitus (GDM) via meta-analysis.
A comprehensive electronic search was performed of the PubMed, Springer, Science Direct, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for studies worldwide on the relationship between HHEX rs5015480 and GDM published up to July 2019. Rigorous inclusion and exclusion criteria were developed, and the quality of studies was assessed using the Newcastle-Ottawa scale, followed by heterogeneity evaluation using the Q test and I statistic and data pooling. A meta-analysis was then performed on the included studies using RevMan 5.3.
A total of 4 eligible case-control studies were included, involving a total of 1651 patients and 3513 controls. The meta-analysis showed the following odds ratios: C allele vs T allele, 1.24 (95% confidence interval [CI]: 1.12-1.38); CC genotype vs TT genotype, 1.65 (95% CI: 1.26-2.17); CC genotype vs CT genotype, 1.22 (95% CI: 1.00-1.50); and CC genotype vs CT + TT genotype, 1.32 (95% CI: 1.09-1.61).
HHEX rs5015480 represents a risk factor for the development of GDM, and pregnant women carrying the CC genotype have an increased risk of GDM.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>32195947</pmid><doi>10.1097/MD.0000000000019478</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Case-Control Studies Diabetes, Gestational - epidemiology Diabetes, Gestational - genetics Evidence-Based Medicine Female Genotype Homeodomain Proteins - genetics Humans Polymorphism, Single Nucleotide - genetics Pregnancy Risk Factors Systematic Review and Meta-Analysis Transcription Factors - genetics |
| title | The association between HHEX single-nucleotide polymorphism rs5015480 and gestational diabetes mellitus: A meta-analysis |
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