Stretta procedure versus proton pump inhibitors for the treatment of nonerosive reflux disease: A 6-month follow-up
To compare the Stretta procedure with proton pump inhibitors for the treatment of nonerosive reflux disease (NERD).From July 2018 to April 2019, patients diagnosed with NERD and referred for treatment were enrolled. They were treated with either Stretta procedure or proton pump inhibitor (PPI) medic...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-01, Vol.99 (3), p.e18610-e18610 |
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| creator | He, Suyu Xu, Fei Xiong, Xin Wang, Hui Cao, Lipeng Liang, Ninglin Wang, Hanmei Jing, Xiaojuan Liu, Tianyu |
| description | To compare the Stretta procedure with proton pump inhibitors for the treatment of nonerosive reflux disease (NERD).From July 2018 to April 2019, patients diagnosed with NERD and referred for treatment were enrolled. They were treated with either Stretta procedure or proton pump inhibitor (PPI) medication and followed-up for 6 months. The symptom control, quality of life, lower esophageal sphincter (LES) pressure, 24-hour pH parameters, PPI usage and satisfaction rate were evaluated. The complications were assessed. The outcomes of the 2 groups were analyzed and compared.Twenty-eight patients in the Stretta group and 21 patients in the PPI group completed the 6-month follow-up. No severe adverse events occurred in both groups. Both interventions were effective in improvement of symptom and quality of life. The symptom score improvement was significantly superior in the Stretta group compared to the PPI group (6.3 ± 3.4 vs 8.5 ± 4.1, P = .03). LES pressure increased significantly in the Stretta group compared to the PPI group (14.2 ± 4.4 mm Hg vs 10.0 ± 4.0 mm Hg, P |
| doi_str_mv | 10.1097/MD.0000000000018610 |
| format | Article |
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They were treated with either Stretta procedure or proton pump inhibitor (PPI) medication and followed-up for 6 months. The symptom control, quality of life, lower esophageal sphincter (LES) pressure, 24-hour pH parameters, PPI usage and satisfaction rate were evaluated. The complications were assessed. The outcomes of the 2 groups were analyzed and compared.Twenty-eight patients in the Stretta group and 21 patients in the PPI group completed the 6-month follow-up. No severe adverse events occurred in both groups. Both interventions were effective in improvement of symptom and quality of life. The symptom score improvement was significantly superior in the Stretta group compared to the PPI group (6.3 ± 3.4 vs 8.5 ± 4.1, P = .03). LES pressure increased significantly in the Stretta group compared to the PPI group (14.2 ± 4.4 mm Hg vs 10.0 ± 4.0 mm Hg, P < .01). Although both interventions improved 24-hour pH parameters, including number of acid episodes (P = .27), acid exposure time (P = .39), and DeMeester score (P = .28), no difference was found between the 2 groups. Complete PPI cessation rate (82% vs 52%, P = .03) as well as satisfaction rate (89% vs 57%, P = .02) was much higher in Stretta group than those in the PPI groupThe Stretta procedure was safe and effective in the short term for the management of NERD. The Stretta procedure resulted in higher LES pressure and achieved better improvement of symptom control and PPI cessation than did PPI in the short term.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000018610</identifier><identifier>PMID: 32011441</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health</publisher><subject>Adult ; Catheter Ablation - adverse effects ; Catheter Ablation - methods ; Esophageal Sphincter, Lower - physiopathology ; Female ; Follow-Up Studies ; Gastroesophageal Reflux - therapy ; Humans ; Hydrogen-Ion Concentration ; Male ; Middle Aged ; Observational Study ; Patient Satisfaction ; Proton Pump Inhibitors - adverse effects ; Proton Pump Inhibitors - therapeutic use ; Quality of Life</subject><ispartof>Medicine (Baltimore), 2020-01, Vol.99 (3), p.e18610-e18610</ispartof><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c310t-8a9f3ad65c721930574c4d962b3b6b69a12da11394d668cfffb214f36b092d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220108/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220108/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32011441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Suyu</creatorcontrib><creatorcontrib>Xu, Fei</creatorcontrib><creatorcontrib>Xiong, Xin</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Cao, Lipeng</creatorcontrib><creatorcontrib>Liang, Ninglin</creatorcontrib><creatorcontrib>Wang, Hanmei</creatorcontrib><creatorcontrib>Jing, Xiaojuan</creatorcontrib><creatorcontrib>Liu, Tianyu</creatorcontrib><title>Stretta procedure versus proton pump inhibitors for the treatment of nonerosive reflux disease: A 6-month follow-up</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To compare the Stretta procedure with proton pump inhibitors for the treatment of nonerosive reflux disease (NERD).From July 2018 to April 2019, patients diagnosed with NERD and referred for treatment were enrolled. They were treated with either Stretta procedure or proton pump inhibitor (PPI) medication and followed-up for 6 months. The symptom control, quality of life, lower esophageal sphincter (LES) pressure, 24-hour pH parameters, PPI usage and satisfaction rate were evaluated. The complications were assessed. The outcomes of the 2 groups were analyzed and compared.Twenty-eight patients in the Stretta group and 21 patients in the PPI group completed the 6-month follow-up. No severe adverse events occurred in both groups. Both interventions were effective in improvement of symptom and quality of life. The symptom score improvement was significantly superior in the Stretta group compared to the PPI group (6.3 ± 3.4 vs 8.5 ± 4.1, P = .03). LES pressure increased significantly in the Stretta group compared to the PPI group (14.2 ± 4.4 mm Hg vs 10.0 ± 4.0 mm Hg, P < .01). Although both interventions improved 24-hour pH parameters, including number of acid episodes (P = .27), acid exposure time (P = .39), and DeMeester score (P = .28), no difference was found between the 2 groups. Complete PPI cessation rate (82% vs 52%, P = .03) as well as satisfaction rate (89% vs 57%, P = .02) was much higher in Stretta group than those in the PPI groupThe Stretta procedure was safe and effective in the short term for the management of NERD. The Stretta procedure resulted in higher LES pressure and achieved better improvement of symptom control and PPI cessation than did PPI in the short term.</description><subject>Adult</subject><subject>Catheter Ablation - adverse effects</subject><subject>Catheter Ablation - methods</subject><subject>Esophageal Sphincter, Lower - physiopathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroesophageal Reflux - therapy</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Patient Satisfaction</subject><subject>Proton Pump Inhibitors - adverse effects</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Quality of Life</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctKBDEQDKLouvoFguToZTSvSTYeBFmfoHjQe8jMJG5kZjImmVX_3iy-7UtDd1V1UwXAHkaHGElxdHt2iH4KzzhGa2CCS8qLUnK2DiYIkbIQUrAtsB3jUwZRQdgm2KIEYcwYnoB4n4JJScMh-No0YzBwaUIc42qQfA-HsRug6xeucsmHCK0PMC0MzDSdOtMn6C3sfW-Cj25pYDC2HV9h46LR0RzDU8iLzvdpkZlt61-KcdgBG1a30ex-9il4uDh_mF8VN3eX1_PTm6KmGKVipqWluuFlLQiWFJWC1ayRnFS04hWXGpNGY0wlazif1dbaimBmKa-QJA2lU3DyITuMVWeaOv8adKuG4Dod3pTXTv3d9G6hHv1SCZLtQbMscPApEPzzaGJSnYu1aVvdGz9GRWiJqEBYiAylH9A62xCzB99nMFKrtNTtmfqfVmbt__7wm_MVD30Hk3iScQ</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>He, Suyu</creator><creator>Xu, Fei</creator><creator>Xiong, Xin</creator><creator>Wang, Hui</creator><creator>Cao, Lipeng</creator><creator>Liang, Ninglin</creator><creator>Wang, Hanmei</creator><creator>Jing, Xiaojuan</creator><creator>Liu, Tianyu</creator><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Stretta procedure versus proton pump inhibitors for the treatment of nonerosive reflux disease: A 6-month follow-up</title><author>He, Suyu ; Xu, Fei ; Xiong, Xin ; Wang, Hui ; Cao, Lipeng ; Liang, Ninglin ; Wang, Hanmei ; Jing, Xiaojuan ; Liu, Tianyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-8a9f3ad65c721930574c4d962b3b6b69a12da11394d668cfffb214f36b092d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Catheter Ablation - adverse effects</topic><topic>Catheter Ablation - methods</topic><topic>Esophageal Sphincter, Lower - physiopathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroesophageal Reflux - therapy</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Patient Satisfaction</topic><topic>Proton Pump Inhibitors - adverse effects</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Suyu</creatorcontrib><creatorcontrib>Xu, Fei</creatorcontrib><creatorcontrib>Xiong, Xin</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Cao, Lipeng</creatorcontrib><creatorcontrib>Liang, Ninglin</creatorcontrib><creatorcontrib>Wang, Hanmei</creatorcontrib><creatorcontrib>Jing, Xiaojuan</creatorcontrib><creatorcontrib>Liu, Tianyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Suyu</au><au>Xu, Fei</au><au>Xiong, Xin</au><au>Wang, Hui</au><au>Cao, Lipeng</au><au>Liang, Ninglin</au><au>Wang, Hanmei</au><au>Jing, Xiaojuan</au><au>Liu, Tianyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stretta procedure versus proton pump inhibitors for the treatment of nonerosive reflux disease: A 6-month follow-up</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>99</volume><issue>3</issue><spage>e18610</spage><epage>e18610</epage><pages>e18610-e18610</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>To compare the Stretta procedure with proton pump inhibitors for the treatment of nonerosive reflux disease (NERD).From July 2018 to April 2019, patients diagnosed with NERD and referred for treatment were enrolled. They were treated with either Stretta procedure or proton pump inhibitor (PPI) medication and followed-up for 6 months. The symptom control, quality of life, lower esophageal sphincter (LES) pressure, 24-hour pH parameters, PPI usage and satisfaction rate were evaluated. The complications were assessed. The outcomes of the 2 groups were analyzed and compared.Twenty-eight patients in the Stretta group and 21 patients in the PPI group completed the 6-month follow-up. No severe adverse events occurred in both groups. Both interventions were effective in improvement of symptom and quality of life. The symptom score improvement was significantly superior in the Stretta group compared to the PPI group (6.3 ± 3.4 vs 8.5 ± 4.1, P = .03). LES pressure increased significantly in the Stretta group compared to the PPI group (14.2 ± 4.4 mm Hg vs 10.0 ± 4.0 mm Hg, P < .01). Although both interventions improved 24-hour pH parameters, including number of acid episodes (P = .27), acid exposure time (P = .39), and DeMeester score (P = .28), no difference was found between the 2 groups. Complete PPI cessation rate (82% vs 52%, P = .03) as well as satisfaction rate (89% vs 57%, P = .02) was much higher in Stretta group than those in the PPI groupThe Stretta procedure was safe and effective in the short term for the management of NERD. The Stretta procedure resulted in higher LES pressure and achieved better improvement of symptom control and PPI cessation than did PPI in the short term.</abstract><cop>United States</cop><pub>Wolters Kluwer Health</pub><pmid>32011441</pmid><doi>10.1097/MD.0000000000018610</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Catheter Ablation - adverse effects Catheter Ablation - methods Esophageal Sphincter, Lower - physiopathology Female Follow-Up Studies Gastroesophageal Reflux - therapy Humans Hydrogen-Ion Concentration Male Middle Aged Observational Study Patient Satisfaction Proton Pump Inhibitors - adverse effects Proton Pump Inhibitors - therapeutic use Quality of Life |
| title | Stretta procedure versus proton pump inhibitors for the treatment of nonerosive reflux disease: A 6-month follow-up |
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