Pooled Knock-In Targeting for Genome Engineering of Cellular Immunotherapies

Adoptive transfer of genetically-modified immune cells holds great promise for cancer immunotherapy. CRISPR knock-in targeting can improve cell therapies, but more high-throughput methods are needed to test which knock-in gene constructs most potently enhance primary cell functions in vivo . We deve...

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Veröffentlicht in:	Cell 2020-04, Vol.181 (3), p.728-744.e21
Hauptverfasser:	Roth, Theodore L., Li, P. Jonathan, Blaeschke, Franziska, Nies, Jasper F., Apathy, Ryan, Mowery, Cody, Yu, Ruby, Nguyen, Michelle L.T., Lee, Youjin, Truong, Anna, Hiatt, Joseph, Wu, David, Nguyen, David N., Goodman, Daniel, Bluestone, Jeffrey A., Ye, Chun Jimmie, Roybal, Kole, Shifrut, Eric, Marson, Alexander
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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