Complement-Dependent Synaptic Uptake and Cognitive Decline after Stroke and Reperfusion Therapy

Despite the success of reperfusion therapy in significantly reducing the extent of infarct expansion after stroke, the effect of revascularization on poststroke neuroinflammation and the role of anti-inflammatory strategies in postreperfusion era are yet to be explored. Here, we investigate whether...

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Veröffentlicht in:	The Journal of neuroscience 2020-05, Vol.40 (20), p.4042-4058
Hauptverfasser:	Alawieh, Ali M, Langley, E Farris, Feng, Wuwei, Spiotta, Alejandro M, Tomlinson, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animal tissues Animals Cognitive ability Cognitive Dysfunction - metabolism Cognitive Dysfunction - psychology Complement Complement activation Complement component C3 Complement System Proteins - metabolism Female Hemorrhage Hippocampus Humans Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - pathology Inflammation Inhibition (psychology) Injury prevention Male Mice Mice, Inbred C57BL Microglia Middle Aged Opsonization Phagocytosis Recovery of Function Reperfusion Stroke Stroke - metabolism Stroke - psychology Stroke - therapy Stroke Rehabilitation Synapses Synapses - metabolism Synaptic density t-Plasminogen activator Therapy Thrombectomy Thrombolysis Thrombolytic Therapy Tissue Plasminogen Activator - therapeutic use Treatment Outcome
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