Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia
•This study examined neuroimaging correlates of phonologic errors in lvPPA.•The inferior parietal lobe and supramarginal gyrus had the strongest correlates.•Atrophy was associated with a greater likelihood of substitution errors in lvPPA.•Thus, specific parietal region atrophy may increase phonologi...
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| Veröffentlicht in: | Brain and language 2020-05, Vol.204, p.104773-104773, Article 104773 |
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| creator | Petroi, Diana Duffy, Joseph R. Borgert, Andrew Strand, Edythe A. Machulda, Mary M. Senjem, Matthew L. Jack, Clifford R. Josephs, Keith A. Whitwell, Jennifer L. |
| description | •This study examined neuroimaging correlates of phonologic errors in lvPPA.•The inferior parietal lobe and supramarginal gyrus had the strongest correlates.•Atrophy was associated with a greater likelihood of substitution errors in lvPPA.•Thus, specific parietal region atrophy may increase phonologic errors in lvPPA.•The results support prior findings of temporoparietal cortex atrophy in lvPPA.
While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA. |
| doi_str_mv | 10.1016/j.bandl.2020.104773 |
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While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA.</description><identifier>ISSN: 0093-934X</identifier><identifier>EISSN: 1090-2155</identifier><identifier>DOI: 10.1016/j.bandl.2020.104773</identifier><identifier>PMID: 32114145</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Aged ; Aphasia ; Aphasia, Primary Progressive - diagnostic imaging ; Aphasia, Primary Progressive - physiopathology ; Brain ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain Mapping ; Female ; Gray Matter - diagnostic imaging ; Gray Matter - physiopathology ; Humans ; Logopenic progressive aphasia ; Male ; Middle Aged ; Neuroanatomical correlates ; Neuroimaging ; Phonologic errors ; Phonology ; Primary progressive aphasia</subject><ispartof>Brain and language, 2020-05, Vol.204, p.104773-104773, Article 104773</ispartof><rights>2020</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Academic Press May 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-aa53ac3fa25d772e0743db6ab5df43d63349d0b0754b4b37e5007ac75aa7cab93</citedby><cites>FETCH-LOGICAL-c553t-aa53ac3fa25d772e0743db6ab5df43d63349d0b0754b4b37e5007ac75aa7cab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bandl.2020.104773$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32114145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petroi, Diana</creatorcontrib><creatorcontrib>Duffy, Joseph R.</creatorcontrib><creatorcontrib>Borgert, Andrew</creatorcontrib><creatorcontrib>Strand, Edythe A.</creatorcontrib><creatorcontrib>Machulda, Mary M.</creatorcontrib><creatorcontrib>Senjem, Matthew L.</creatorcontrib><creatorcontrib>Jack, Clifford R.</creatorcontrib><creatorcontrib>Josephs, Keith A.</creatorcontrib><creatorcontrib>Whitwell, Jennifer L.</creatorcontrib><title>Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia</title><title>Brain and language</title><addtitle>Brain Lang</addtitle><description>•This study examined neuroimaging correlates of phonologic errors in lvPPA.•The inferior parietal lobe and supramarginal gyrus had the strongest correlates.•Atrophy was associated with a greater likelihood of substitution errors in lvPPA.•Thus, specific parietal region atrophy may increase phonologic errors in lvPPA.•The results support prior findings of temporoparietal cortex atrophy in lvPPA.
While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA.</description><subject>Aged</subject><subject>Aphasia</subject><subject>Aphasia, Primary Progressive - diagnostic imaging</subject><subject>Aphasia, Primary Progressive - physiopathology</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Female</subject><subject>Gray Matter - diagnostic imaging</subject><subject>Gray Matter - physiopathology</subject><subject>Humans</subject><subject>Logopenic progressive aphasia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroanatomical correlates</subject><subject>Neuroimaging</subject><subject>Phonologic errors</subject><subject>Phonology</subject><subject>Primary progressive aphasia</subject><issn>0093-934X</issn><issn>1090-2155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhq2Kii6FX1AJReLSS7b-jJMDSFVVaKUKOIDEzZo4k12vsnawk5X67-tlS0V74OTxzDOvPfMScsboklFWXWyWLfhuWHLK9xmptTgiC0YbWnKm1CuyoLQRZSPkrxPyJqUNpYzJmr0mJ4LniEm1IN-_4hwDeJjC1lkYChtixAEmTEXoi3EdfBjCytkCYwwxFc4X-R5G9Dk3xrCKmJLbYQHjGpKDt-S4hyHhu8fzlPz8fP3j6qa8-_bl9uryrrRKiakEUAKs6IGrTmuOVEvRtRW0qutzVAkhm462VCvZylZoVJRqsFoBaAttI07Jp4PuOLdb7Cz6KcJgxui2EO9NAGeeV7xbm1XYGc1Zw2uRBc4fBWL4PWOazNYli8MAHsOcDBdVU-tK1CqjH16gmzBHn8czXArdsLquq0yJA2VjSCli__QZRs3eMbMxfxwze8fMwbHc9f7fOZ56_lqUgY8HAPM2dw6jSdaht9i5iHYyXXD_feABK-mqJg</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Petroi, Diana</creator><creator>Duffy, Joseph R.</creator><creator>Borgert, Andrew</creator><creator>Strand, Edythe A.</creator><creator>Machulda, Mary M.</creator><creator>Senjem, Matthew L.</creator><creator>Jack, Clifford R.</creator><creator>Josephs, Keith A.</creator><creator>Whitwell, Jennifer L.</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T9</scope><scope>8BM</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200501</creationdate><title>Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia</title><author>Petroi, Diana ; Duffy, Joseph R. ; Borgert, Andrew ; Strand, Edythe A. ; Machulda, Mary M. ; Senjem, Matthew L. ; Jack, Clifford R. ; Josephs, Keith A. ; Whitwell, Jennifer L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-aa53ac3fa25d772e0743db6ab5df43d63349d0b0754b4b37e5007ac75aa7cab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aphasia</topic><topic>Aphasia, Primary Progressive - diagnostic imaging</topic><topic>Aphasia, Primary Progressive - physiopathology</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Female</topic><topic>Gray Matter - diagnostic imaging</topic><topic>Gray Matter - physiopathology</topic><topic>Humans</topic><topic>Logopenic progressive aphasia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroanatomical correlates</topic><topic>Neuroimaging</topic><topic>Phonologic errors</topic><topic>Phonology</topic><topic>Primary progressive aphasia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petroi, Diana</creatorcontrib><creatorcontrib>Duffy, Joseph R.</creatorcontrib><creatorcontrib>Borgert, Andrew</creatorcontrib><creatorcontrib>Strand, Edythe A.</creatorcontrib><creatorcontrib>Machulda, Mary M.</creatorcontrib><creatorcontrib>Senjem, Matthew L.</creatorcontrib><creatorcontrib>Jack, Clifford R.</creatorcontrib><creatorcontrib>Josephs, Keith A.</creatorcontrib><creatorcontrib>Whitwell, Jennifer L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><collection>ComDisDome</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain and language</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petroi, Diana</au><au>Duffy, Joseph R.</au><au>Borgert, Andrew</au><au>Strand, Edythe A.</au><au>Machulda, Mary M.</au><au>Senjem, Matthew L.</au><au>Jack, Clifford R.</au><au>Josephs, Keith A.</au><au>Whitwell, Jennifer L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia</atitle><jtitle>Brain and language</jtitle><addtitle>Brain Lang</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>204</volume><spage>104773</spage><epage>104773</epage><pages>104773-104773</pages><artnum>104773</artnum><issn>0093-934X</issn><eissn>1090-2155</eissn><abstract>•This study examined neuroimaging correlates of phonologic errors in lvPPA.•The inferior parietal lobe and supramarginal gyrus had the strongest correlates.•Atrophy was associated with a greater likelihood of substitution errors in lvPPA.•Thus, specific parietal region atrophy may increase phonologic errors in lvPPA.•The results support prior findings of temporoparietal cortex atrophy in lvPPA.
While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>32114145</pmid><doi>10.1016/j.bandl.2020.104773</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aphasia Aphasia, Primary Progressive - diagnostic imaging Aphasia, Primary Progressive - physiopathology Brain Brain - diagnostic imaging Brain - physiopathology Brain Mapping Female Gray Matter - diagnostic imaging Gray Matter - physiopathology Humans Logopenic progressive aphasia Male Middle Aged Neuroanatomical correlates Neuroimaging Phonologic errors Phonology Primary progressive aphasia |
| title | Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia |
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