Regulation of barrier immunity and homeostasis by integrin‐mediated transforming growth factor β activation

Summary Transforming growth factor β (TGF‐β) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. Various cell types secrete TGF‐β, but always as an inactive complex. Hence, for TGF...

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Veröffentlicht in:	Immunology 2020-06, Vol.160 (2), p.139-148
Hauptverfasser:	McEntee, Craig P., Gunaltay, Sezin, Travis, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Cell death Cell differentiation Cell migration Cytokines Disease Models, Animal Gastrointestinal Microbiome - immunology Growth factors Homeostasis Homeostasis - immunology Humans immune system Immunity Integrin alphaV - metabolism Integrins Intestinal Diseases - immunology Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology intestine lung Lung - immunology Lung - metabolism Lung Diseases - immunology Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Review Review Series: Barrier Immunity Signal Transduction - immunology skin Skin - immunology Skin - metabolism Skin - microbiology Skin Diseases - immunology Therapeutic applications Transforming Growth Factor beta - metabolism Transforming growth factor-b transforming growth factor‐β
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