Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial

Background Cardiotoxicity is the most significant adverse event associated with trastuzumab (T), the main component of HER2-positive breast cancer (BC) treatment. Less is known about the cardiotoxicity of dual HER2 blockade with T plus lapatinib (L), although this regimen is used in the metastatic s...

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Veröffentlicht in:	British journal of cancer 2020-05, Vol.122 (10), p.1453-1460
Hauptverfasser:	Eiger, Daniel, Pondé, Noam F., Agbor-Tarh, Dominique, Moreno-Aspitia, Alvaro, Piccart, Martine, Hilbers, Florentine S., Werner, Olena, Chumsri, Saranya, Dueck, Amylou, Kroep, Judith R., Gomez, Henry, Láng, István, Rodeheffer, Richard J., Ewer, Michael S., Suter, Thomas, de Azambuja, Evandro
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67/1059/602 692/4028/67/1347 Adult Aged Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - complications Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer Research Cardiotoxicity Cardiotoxicity - etiology Cardiotoxicity - genetics Cardiotoxicity - pathology Diabetes mellitus Disease-Free Survival Doxorubicin Doxorubicin - adverse effects Drug Resistance Epidemiology Epirubicin Epirubicin - adverse effects ErbB-2 protein Female Heart Humans Immunotherapy Inhibitor drugs Lapatinib - administration & dosage Lapatinib - adverse effects Metastases Middle Aged Molecular Medicine Monoclonal antibodies Neoadjuvant Therapy - adverse effects Oncology Patients Quinazolines - adverse effects Receptor, ErbB-2 - genetics Registration Risk factors Targeted cancer therapy Trastuzumab Trastuzumab - administration & dosage Trastuzumab - adverse effects Treatment Outcome
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