Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma

Cisplatin is the first-line chemotherapeutic agent for the treatment of oral squamous cell carcinoma (OSCC). However, the intrinsic or acquired resistance against cisplatin remains a major obstacle to treatment efficacy in OSCC. Recently, mitochondrial DNA (mtDNA) alterations have been reported in a...

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Veröffentlicht in:	Scientific reports 2020-05, Vol.10 (1), p.7885, Article 7885
Hauptverfasser:	Aminuddin, Amnani, Ng, Pei Yuen, Leong, Chee-Onn, Chua, Eng Wee
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/31 38 38/22 38/23 38/77 38/90 45 45/61 692/4028/67/68 692/53/2423 82 82/1 82/80 Alternative energy sources Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics Cell Survival - drug effects Cell Survival - genetics Chemotherapy Cisplatin Cisplatin - pharmacology Deoxyribonucleic acid DNA DNA microarrays DNA, Mitochondrial - drug effects DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Epigenetics Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - drug effects Genomes Glucose metabolism Glycolysis Humanities and Social Sciences Humans Lipid metabolism Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology multidisciplinary Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Oral cancer Oral squamous cell carcinoma Science Science (multidisciplinary) Squamous cell carcinoma Stem cells Toxicity Tumors
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