Iridium‐Catalyzed Enantioselective Intermolecular Indole C2‐Allylation

The enantioselective intermolecular C2‐allylation of 3‐substituted indoles is reported for the first time. This directing group‐free approach relies on a chiral Ir‐(P, olefin) complex and Mg(ClO4)2 Lewis acid catalyst system to promote allylic substitution, providing the C2‐allylated products in typ...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-05, Vol.59 (19), p.7598-7604
Hauptverfasser:	Rossi‐Ashton, James A., Clarke, Aimee K., Donald, James R., Zheng, Chao, Taylor, Richard J. K., Unsworth, William P., You, Shu‐Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl compounds allylic substitution Catalysts Chemical reactions DFT calculations Enantiomers enantioselective synthesis indole Indoles Iridium Lewis acid Magnesium perchlorates Selectivity Substitution reactions
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