Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4+ T cells from lean, normoglyce...

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Veröffentlicht in:	Cell metabolism 2020-07, Vol.32 (1), p.44-55.e6
Hauptverfasser:	Bharath, Leena P., Agrawal, Madhur, McCambridge, Grace, Nicholas, Dequina A., Hasturk, Hatice, Liu, Jing, Jiang, Kai, Liu, Rui, Guo, Zhenheng, Deeney, Jude, Apovian, Caroline M., Snyder-Cappione, Jennifer, Hawk, Gregory S., Fleeman, Rebecca M., Pihl, Riley M.F., Thompson, Katherine, Belkina, Anna C., Cui, Licong, Proctor, Elizabeth A., Kern, Philip A., Nikolajczyk, Barbara S.
Format:	Artikel
Sprache:	eng
Schlagworte:	autophagy inflammaging metformin mitochondria T cells
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