Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure
Abstract Background Biomarkers are needed for early identification of patients at risk of severe complications from influenza infection, including prolonged respiratory failure and death. Eicosanoids are bioactive lipid mediators with pro- and anti-inflammatory properties produced in response to inf...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2020-05, Vol.7 (5), p.ofaa122-ofaa122 |
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| creator | Anania, Veronica G Randolph, Adrienne G Yang, Xiaoying Nguyen, Allen Newhams, Margaret M Mathews, W Rodney Rosenberger, Carrie M McBride, Jacqueline M |
| description | Abstract
Background
Biomarkers are needed for early identification of patients at risk of severe complications from influenza infection, including prolonged respiratory failure and death. Eicosanoids are bioactive lipid mediators with pro- and anti-inflammatory properties produced in response to infection. This study assessed the relationships between the host bioactive lipid response, influenza viral load, and clinical outcomes.
Methods
Influenza-positive, intubated children ≤18 years old were enrolled across 26 US pediatric intensive care units (PICUs). Mass spectrometry was used to measure >100 lipid metabolites in endotracheal and nasopharyngeal samples. Influenza viral load was measured by quantitative polymerase chain reaction.
Results
Age and bacterial co-infection were associated with multiple bioactive lipids (P |
| doi_str_mv | 10.1093/ofid/ofaa122 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7216777</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A698251051</galeid><oup_id>10.1093/ofid/ofaa122</oup_id><sourcerecordid>A698251051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-92c7cd723fab7b997d2c98f4b5ca2e8f4c5a2c613881e64765949d188b3c04953</originalsourceid><addsrcrecordid>eNp9kU9rFDEYxgdRbKm9eZbc9ODU_JnZJBdhW1pdWKgUpceQybzTvpKZjMlMYf0GfmtTZy3rRQJJyPN7niQ8RfGa0TNGtfgQOmzzZC3j_FlxzAVXpdK1fH6wPypOU_pOKWWM1lTql8WR4BWnFRXHxa9LG_2OrPvRY4fQkhtII0Y7hbgj5xism_AByBZHXLQwJCCbRNYpBYd2ypZbnO7JbYhZuJ4nF3pIBAfyBdqsR3RkM3R-huGnLW_A_7Ec3nJl0c8RXhUvOusTnO7Xk-Lb1eXXi8_l9vrT5mK9LV3FxFRq7qRrJRedbWSjtWy506qrmtpZDnnjasvdigmlGKwquap1pVumVCMcrXQtToqPS-44Nz20DoYpWm_GiL2NOxMsmn-VAe_NXXgwkrOVlDIHvNsHxPBjhjSZHpMD7-0AYU6GV7QSinMlMnq2oHfWg8GhCznR5dFCjy4M0GE-X6-04nUuh2XD-8XgYkgpQvf0LkbNY-PmsXGzbzzjbw7_8gT_7TcDbxcgzOP_o34Dgl24gA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2404382283</pqid></control><display><type>article</type><title>Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure</title><source>DOAJ Directory of Open Access Journals</source><source>Oxford Journals Open Access Collection</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Anania, Veronica G ; Randolph, Adrienne G ; Yang, Xiaoying ; Nguyen, Allen ; Newhams, Margaret M ; Mathews, W Rodney ; Rosenberger, Carrie M ; McBride, Jacqueline M</creator><creatorcontrib>Anania, Veronica G ; Randolph, Adrienne G ; Yang, Xiaoying ; Nguyen, Allen ; Newhams, Margaret M ; Mathews, W Rodney ; Rosenberger, Carrie M ; McBride, Jacqueline M</creatorcontrib><description>Abstract
Background
Biomarkers are needed for early identification of patients at risk of severe complications from influenza infection, including prolonged respiratory failure and death. Eicosanoids are bioactive lipid mediators with pro- and anti-inflammatory properties produced in response to infection. This study assessed the relationships between the host bioactive lipid response, influenza viral load, and clinical outcomes.
Methods
Influenza-positive, intubated children ≤18 years old were enrolled across 26 US pediatric intensive care units (PICUs). Mass spectrometry was used to measure >100 lipid metabolites in endotracheal and nasopharyngeal samples. Influenza viral load was measured by quantitative polymerase chain reaction.
Results
Age and bacterial co-infection were associated with multiple bioactive lipids (P < .05). Influenza viral load was lower in patients with bacterial co-infection compared with those without, and pro-inflammatory bioactive lipids positively correlated with viral load in bacterially co-infected children (P < .05). Lipids associated with disease resolution correlated with viral load in patients without bacterial co-infection (P < .01). After adjusting for age and bacterial co-infection status, elevated pro- and anti-inflammatory lipids measured early in the intensive care unit course were associated with higher mortality, whereas influenza viral load and endotracheal cytokine levels were not associated with clinical outcomes. Prostaglandin E2, arachidonic acid, docosahexaenoic acid, and 12-hydroxyeicosatetraenoic acid measured within 72 hours of PICU admission predicted death or prolonged (≥28 days) mechanical ventilator support (area under the curve, 0.72–0.79; P < .02) not explained by admission illness severity.
Conclusions
Children with influenza-related complications have early bioactive lipid responses that may reflect lung disease severity. Respiratory bioactive lipids are candidate prognostic biomarkers to identify children with the most severe clinical outcomes.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofaa122</identifier><identifier>PMID: 32420403</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Arachidonic acid ; Bacterial infections ; Children ; Diseases ; Health aspects ; Influenza ; Lung diseases ; Major ; Mass spectrometry ; Medical research ; Medicine, Experimental ; Metabolites ; Methicillin ; Omega-3 fatty acids ; Pediatric intensive care ; Prostaglandins E ; Respiratory insufficiency ; Unsaturated fatty acids</subject><ispartof>Open Forum Infectious Diseases, 2020-05, Vol.7 (5), p.ofaa122-ofaa122</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-92c7cd723fab7b997d2c98f4b5ca2e8f4c5a2c613881e64765949d188b3c04953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216777/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216777/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32420403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anania, Veronica G</creatorcontrib><creatorcontrib>Randolph, Adrienne G</creatorcontrib><creatorcontrib>Yang, Xiaoying</creatorcontrib><creatorcontrib>Nguyen, Allen</creatorcontrib><creatorcontrib>Newhams, Margaret M</creatorcontrib><creatorcontrib>Mathews, W Rodney</creatorcontrib><creatorcontrib>Rosenberger, Carrie M</creatorcontrib><creatorcontrib>McBride, Jacqueline M</creatorcontrib><title>Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Background
Biomarkers are needed for early identification of patients at risk of severe complications from influenza infection, including prolonged respiratory failure and death. Eicosanoids are bioactive lipid mediators with pro- and anti-inflammatory properties produced in response to infection. This study assessed the relationships between the host bioactive lipid response, influenza viral load, and clinical outcomes.
Methods
Influenza-positive, intubated children ≤18 years old were enrolled across 26 US pediatric intensive care units (PICUs). Mass spectrometry was used to measure >100 lipid metabolites in endotracheal and nasopharyngeal samples. Influenza viral load was measured by quantitative polymerase chain reaction.
Results
Age and bacterial co-infection were associated with multiple bioactive lipids (P < .05). Influenza viral load was lower in patients with bacterial co-infection compared with those without, and pro-inflammatory bioactive lipids positively correlated with viral load in bacterially co-infected children (P < .05). Lipids associated with disease resolution correlated with viral load in patients without bacterial co-infection (P < .01). After adjusting for age and bacterial co-infection status, elevated pro- and anti-inflammatory lipids measured early in the intensive care unit course were associated with higher mortality, whereas influenza viral load and endotracheal cytokine levels were not associated with clinical outcomes. Prostaglandin E2, arachidonic acid, docosahexaenoic acid, and 12-hydroxyeicosatetraenoic acid measured within 72 hours of PICU admission predicted death or prolonged (≥28 days) mechanical ventilator support (area under the curve, 0.72–0.79; P < .02) not explained by admission illness severity.
Conclusions
Children with influenza-related complications have early bioactive lipid responses that may reflect lung disease severity. Respiratory bioactive lipids are candidate prognostic biomarkers to identify children with the most severe clinical outcomes.</description><subject>Arachidonic acid</subject><subject>Bacterial infections</subject><subject>Children</subject><subject>Diseases</subject><subject>Health aspects</subject><subject>Influenza</subject><subject>Lung diseases</subject><subject>Major</subject><subject>Mass spectrometry</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolites</subject><subject>Methicillin</subject><subject>Omega-3 fatty acids</subject><subject>Pediatric intensive care</subject><subject>Prostaglandins E</subject><subject>Respiratory insufficiency</subject><subject>Unsaturated fatty acids</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kU9rFDEYxgdRbKm9eZbc9ODU_JnZJBdhW1pdWKgUpceQybzTvpKZjMlMYf0GfmtTZy3rRQJJyPN7niQ8RfGa0TNGtfgQOmzzZC3j_FlxzAVXpdK1fH6wPypOU_pOKWWM1lTql8WR4BWnFRXHxa9LG_2OrPvRY4fQkhtII0Y7hbgj5xism_AByBZHXLQwJCCbRNYpBYd2ypZbnO7JbYhZuJ4nF3pIBAfyBdqsR3RkM3R-huGnLW_A_7Ec3nJl0c8RXhUvOusTnO7Xk-Lb1eXXi8_l9vrT5mK9LV3FxFRq7qRrJRedbWSjtWy506qrmtpZDnnjasvdigmlGKwquap1pVumVCMcrXQtToqPS-44Nz20DoYpWm_GiL2NOxMsmn-VAe_NXXgwkrOVlDIHvNsHxPBjhjSZHpMD7-0AYU6GV7QSinMlMnq2oHfWg8GhCznR5dFCjy4M0GE-X6-04nUuh2XD-8XgYkgpQvf0LkbNY-PmsXGzbzzjbw7_8gT_7TcDbxcgzOP_o34Dgl24gA</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Anania, Veronica G</creator><creator>Randolph, Adrienne G</creator><creator>Yang, Xiaoying</creator><creator>Nguyen, Allen</creator><creator>Newhams, Margaret M</creator><creator>Mathews, W Rodney</creator><creator>Rosenberger, Carrie M</creator><creator>McBride, Jacqueline M</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200501</creationdate><title>Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure</title><author>Anania, Veronica G ; Randolph, Adrienne G ; Yang, Xiaoying ; Nguyen, Allen ; Newhams, Margaret M ; Mathews, W Rodney ; Rosenberger, Carrie M ; McBride, Jacqueline M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-92c7cd723fab7b997d2c98f4b5ca2e8f4c5a2c613881e64765949d188b3c04953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Arachidonic acid</topic><topic>Bacterial infections</topic><topic>Children</topic><topic>Diseases</topic><topic>Health aspects</topic><topic>Influenza</topic><topic>Lung diseases</topic><topic>Major</topic><topic>Mass spectrometry</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metabolites</topic><topic>Methicillin</topic><topic>Omega-3 fatty acids</topic><topic>Pediatric intensive care</topic><topic>Prostaglandins E</topic><topic>Respiratory insufficiency</topic><topic>Unsaturated fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anania, Veronica G</creatorcontrib><creatorcontrib>Randolph, Adrienne G</creatorcontrib><creatorcontrib>Yang, Xiaoying</creatorcontrib><creatorcontrib>Nguyen, Allen</creatorcontrib><creatorcontrib>Newhams, Margaret M</creatorcontrib><creatorcontrib>Mathews, W Rodney</creatorcontrib><creatorcontrib>Rosenberger, Carrie M</creatorcontrib><creatorcontrib>McBride, Jacqueline M</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anania, Veronica G</au><au>Randolph, Adrienne G</au><au>Yang, Xiaoying</au><au>Nguyen, Allen</au><au>Newhams, Margaret M</au><au>Mathews, W Rodney</au><au>Rosenberger, Carrie M</au><au>McBride, Jacqueline M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>7</volume><issue>5</issue><spage>ofaa122</spage><epage>ofaa122</epage><pages>ofaa122-ofaa122</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Background
Biomarkers are needed for early identification of patients at risk of severe complications from influenza infection, including prolonged respiratory failure and death. Eicosanoids are bioactive lipid mediators with pro- and anti-inflammatory properties produced in response to infection. This study assessed the relationships between the host bioactive lipid response, influenza viral load, and clinical outcomes.
Methods
Influenza-positive, intubated children ≤18 years old were enrolled across 26 US pediatric intensive care units (PICUs). Mass spectrometry was used to measure >100 lipid metabolites in endotracheal and nasopharyngeal samples. Influenza viral load was measured by quantitative polymerase chain reaction.
Results
Age and bacterial co-infection were associated with multiple bioactive lipids (P < .05). Influenza viral load was lower in patients with bacterial co-infection compared with those without, and pro-inflammatory bioactive lipids positively correlated with viral load in bacterially co-infected children (P < .05). Lipids associated with disease resolution correlated with viral load in patients without bacterial co-infection (P < .01). After adjusting for age and bacterial co-infection status, elevated pro- and anti-inflammatory lipids measured early in the intensive care unit course were associated with higher mortality, whereas influenza viral load and endotracheal cytokine levels were not associated with clinical outcomes. Prostaglandin E2, arachidonic acid, docosahexaenoic acid, and 12-hydroxyeicosatetraenoic acid measured within 72 hours of PICU admission predicted death or prolonged (≥28 days) mechanical ventilator support (area under the curve, 0.72–0.79; P < .02) not explained by admission illness severity.
Conclusions
Children with influenza-related complications have early bioactive lipid responses that may reflect lung disease severity. Respiratory bioactive lipids are candidate prognostic biomarkers to identify children with the most severe clinical outcomes.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32420403</pmid><doi>10.1093/ofid/ofaa122</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Oxford Journals Open Access Collection; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Arachidonic acid Bacterial infections Children Diseases Health aspects Influenza Lung diseases Major Mass spectrometry Medical research Medicine, Experimental Metabolites Methicillin Omega-3 fatty acids Pediatric intensive care Prostaglandins E Respiratory insufficiency Unsaturated fatty acids |
| title | Early Amplified Respiratory Bioactive Lipid Response Is Associated With Worse Outcomes in Pediatric Influenza-Related Respiratory Failure |
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