Arctigenin Enhances the Cytotoxic Effect of Doxorubicin in MDA-MB-231 Breast Cancer Cells

Several reports have described the anti-cancer activity of arctigenin, a lignan extracted from Arctium lappa L. Here, we investigated the effect of arctigenin (ATG) on doxorubicin (DOX)-induced cell death using MDA-MB-231 human breast cancer cells. The results showed that DOX-induced cell death was...

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Veröffentlicht in:	International journal of molecular sciences 2020-04, Vol.21 (8), p.2997, Article 2997
Hauptverfasser:	Lee, Kyu-Shik, Lee, Min-Gu, Kwon, Yun-Suk, Nam, Kyung-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antibiotics, Antineoplastic - pharmacology Apoptosis Apoptosis - drug effects Apoptosis-inducing factor arctigenin Autophagy BAX protein Bcl-2 protein Bcl-x protein Biochemistry & Molecular Biology Biomarkers, Tumor Breast cancer c-Jun protein Cancer therapies Caspase-3 Cell cycle Cell death Cell Line, Tumor Cell Survival - drug effects Chemistry Chemistry, Multidisciplinary Cyclin-dependent kinases Cytotoxicity Deoxyribonucleic acid DNA DNA damage DNA repair Dose-Response Relationship, Drug Doxorubicin Doxorubicin - pharmacology Drug dosages Drug Synergism Furans - pharmacology Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans JNK protein Kinases Life Sciences & Biomedicine Lignans - pharmacology Lymphoma MAP Kinase Signaling System - drug effects Metastasis Mitochondria Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism Multidrug resistance Nuclear transport Phosphorylation Physical Sciences Proteins Science & Technology Signal transduction Stat3 protein Survivin Transcription factors triple-negative breast cancer
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