Modified DNA Aptamers for C-Reactive Protein and Lactate Dehydrogenase-5 with Sub-Nanomolar Affinities

Human C-reactive protein (CRP) and lactate dehydrogenase are important markers in clinical laboratory testing-the former is used to detect in vivo inflammation, and the latter is used to detect cell necrosis and tissue destruction. We developed aptamers that bind to human CRP and human lactate dehyd...

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Veröffentlicht in:	International journal of molecular sciences 2020-04, Vol.21 (8), p.2683
Hauptverfasser:	Minagawa, Hirotaka, Kataoka, Yuka, Fujita, Hiroto, Kuwahara, Masayasu, Horii, Katsunori, Shiratori, Ikuo, Waga, Iwao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Affinity Amino acids Aptamers Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - genetics Base Sequence Binding sites Biosensors C-reactive protein C-Reactive Protein - genetics Candidates Dehydrogenases Deoxyribonucleic acid DNA DNA, Single-Stranded Enzymes Gene Library Guanine Humans In vivo methods and tests L-Lactate dehydrogenase Lactate dehydrogenase Lactate Dehydrogenase 5 - genetics Lactic acid Molecular Structure Necrosis Position sensing Proteins SELEX Aptamer Technique Uracil
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