Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA)

In previous studies, we produced changes in gene expression in the brain of mice by early postnatal administration of valproic acid (VPA), with distinct differences between genders. The addition of S-adenosine methionine (SAMe) normalized the expression of most genes in both genders, while SAMe alon...

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Veröffentlicht in:	International journal of molecular sciences 2020-04, Vol.21 (8), p.2834
Hauptverfasser:	Weinstein-Fudim, Liza, Ergaz, Zivanit, Szyf, Moshe, Ornoy, Asher
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adenosine Animals Animals, Newborn Autism Autism Spectrum Disorder - drug therapy Autism Spectrum Disorder - metabolism Behavior Brain - drug effects Brain - metabolism Congenital diseases Defects Embryos Epigenesis, Genetic - drug effects Epigenetics Female Gallbladder diseases Gender Gene expression Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics Gene Ontology Genes Gestation Growth factors Hypotheses Male Methionine Mice Neurophysiology Oxidative stress Pregnancy Prenatal Exposure Delayed Effects - drug therapy Prenatal Exposure Delayed Effects - metabolism Pretreatment S-Adenosylmethionine - administration & dosage S-Adenosylmethionine - metabolism Signal Transduction - drug effects Signal Transduction - genetics Social interaction Statistical analysis Teratogens Transcriptome Valproic acid Valproic Acid - administration & dosage Vascular endothelial growth factor Vascular Endothelial Growth Factor A - drug effects Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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