Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA

Metazoan microRNAs require specific maturation steps initiated by Microprocessor, comprising Drosha and DGCR8. Lack of structural information for the assembled complex has hindered an understanding of how Microprocessor recognizes primary microRNA transcripts (pri-miRNAs). Here we present a cryoelec...

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Veröffentlicht in:	Molecular cell 2020-05, Vol.78 (3), p.411-422.e4
Hauptverfasser:	Partin, Alexander C., Zhang, Kaiming, Jeong, Byung-Cheon, Herrell, Emily, Li, Shanshan, Chiu, Wah, Nam, Yunsun
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES cryo-EM Cryoelectron Microscopy DGCR8 Drosha dsRBD Humans Microprocessor microRNA MicroRNAs - chemistry MicroRNAs - metabolism Models, Molecular pri-miRNA Protein Conformation Ribonuclease III - chemistry Ribonuclease III - metabolism RNA processing RNA, Double-Stranded - chemistry RNA, Double-Stranded - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism RNase III structure
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