Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling

Pressure overload (PO) cardiac hypertrophy and heart failure are associated with generalized insulin resistance and hyperinsulinemia, which may exacerbate left ventricular (LV) remodeling. While PO activates insulin receptor tyrosine kinase activity that is transduced by insulin receptor substrate 1...

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Veröffentlicht in:	JCI insight 2020-03, Vol.5 (6)
Hauptverfasser:	Riehle, Christian, Weatherford, Eric T, Wende, Adam R, Jaishy, Bharat P, Seei, Alec W, McCarty, Nicholas S, Rech, Monika, Shi, Qian, Reddy, Gopireddy R, Kutschke, William J, Oliveira, Karen, Pires, Karla Maria, Anderson, Joshua C, Diakos, Nikolaos A, Weiss, Robert M, White, Morris F, Drakos, Stavros G, Xiang, Yang K, Abel, E Dale
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly - complications Humans Hyperinsulinism - complications Insulin - metabolism Insulin Receptor Substrate Proteins - metabolism Insulin Resistance - physiology Mice Mice, Knockout Proto-Oncogene Proteins c-akt - metabolism Ventricular Remodeling - physiology
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