Integrating Multiple Biomarkers to Increase Sensitivity for the Detection of Onchocerca volvulus Infection

Serological assessment of IgG4 responses to a combination of biomarkers for onchocerciasis enables enhanced case detection (at individual and community level), a current and urgent need towards elimination of the disease as a global health problem. Abstract Background Serological assessments for hum...

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Veröffentlicht in:	The Journal of infectious diseases 2020-05, Vol.221 (11), p.1805-1815
Hauptverfasser:	Bennuru, Sasisekhar, Oduro-Boateng, Georgiette, Osigwe, Chinweoke, Del Valle, Priscilla, Golden, Allison, Ogawa, Guilherme Maerschner, Cama, Vitaliano, Lustigman, Sara, Nutman, Thomas B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Helminth - blood Antibodies, Helminth - immunology Antigens Antigens, Helminth - immunology Biomarkers Editor's Choice Enzyme-Linked Immunosorbent Assay Humans Immunoassay Immunoglobulin G Immunoglobulin G - blood Immunoprecipitation Major and Brief Reports Medical diagnosis Microfilariae - immunology Onchocerca volvulus - immunology Onchocerca volvulus - isolation & purification Onchocerciasis Onchocerciasis - diagnosis Onchocerciasis - immunology Pan troglodytes Primates - immunology Sensitivity and Specificity
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