Mucolipin‐1 Is a Lysosomal Membrane Protein Required for Intracellular Lactosylceramide Traffic

Mucolipin‐1 is a membrane protein encoded by the gene MCOLN1, mutations in which result in the lysosomal storage disorder mucolipidosis type IV (MLIV). Efficient lysosomal targeting of mucolipin‐1 requires di‐leucine motifs in both the N‐terminal and the C‐terminal cytosolic tails. We have shown tha...

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