A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption

HIV-1 persists in cellular reservoirs that can reignite viremia if antiretroviral therapy (ART) is interrupted. Therefore, insight into the nature of those reservoirs may be revealed from the composition of recrudescing viremia following treatment cessation. A minor population of macrophage-tropic (...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-05, Vol.117 (18), p.9981-9990
Hauptverfasser:	Andrade, Viviane M., Mavian, Carla, Babic, Dunja, Cordeiro, Thaissa, Sharkey, Mark, Barrios, Labelle, Brander, Christian, Martinez-Picado, Javier, Dalmau, Judith, Llano, Anuska, Li, Jonathan Z., Jacobson, Jeffrey, Lavine, Christy L., Seaman, Michael S., Salemi, Marco, Stevenson, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Retroviral Agents - pharmacology Antibodies Antiretroviral agents Antiretroviral therapy Antiretroviral Therapy, Highly Active Biological Clocks - genetics Biological Sciences CD14 antigen CD3 antigen CD4 antigen CD4-Positive T-Lymphocytes - pathology HIV HIV Infections - genetics HIV Infections - pathology HIV Infections - virology HIV Seropositivity HIV-1 - genetics HIV-1 - pathogenicity Human immunodeficiency virus Humans Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Macrophages - pathology Proviruses - genetics Viral Load - genetics Viremia Viremia - genetics Viremia - pathology Viremia - virology Viruses
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