Designing precision medicine trials to yield a greater population impact

Traditionally, a clinical trial is conducted comparing treatment to standard care for all patients. However, it could be inefficient given patients’ heterogeneous responses to treatments, and rapid advances in the molecular understanding of diseases have made biomarker‐based clinical trials increasi...

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Veröffentlicht in:	Biometrics 2020-06, Vol.76 (2), p.643-653
Hauptverfasser:	Zhao, Ying‐Qi, LeBlanc, Michael L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biomarkers Clinical trials Computer simulation Design Optimization Patients population impact Precision medicine targeted clinical trial design
Online-Zugang:	Volltext
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