p300/CBP inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer

Blockade of programmed death-ligand 1 (PD-L1) by therapeutic antibodies has shown to be a promising strategy in cancer therapy, yet clinical response in many types of cancer, including prostate cancer (PCa), is limited. Tumor cells secrete PD-L1 through exosomes or splice variants, which has been de...

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Veröffentlicht in:	Oncogene 2020-05, Vol.39 (19), p.3939-3951
Hauptverfasser:	Liu, Jinghui, He, Daheng, Cheng, Lijun, Huang, Changkun, Zhang, Yanquan, Rao, Xiongjian, Kong, Yifan, Li, Chaohao, Zhang, Zhuangzhuang, Liu, Jinpeng, Jones, Karrie, Napier, Dana, Lee, Eun Y., Wang, Chi, Liu, Xiaoqi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/31 13/51 13/89 38/1 45/77 631/67/1059/2325 631/67/589/466 64/60 Acetylation Alternative splicing Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Apoptosis B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - genetics Cancer Care and treatment Cell Biology Cell Line, Tumor Drug therapy Epigenetic inheritance Epigenetics Event-related potentials Exosomes Gene Expression Regulation, Neoplastic - drug effects Histone H3 Histones Human Genetics Humans Immune checkpoint inhibitors Immunotherapy - methods Interferon regulatory factor 1 Interferon Regulatory Factor-1 - genetics Interferon-gamma - genetics Internal Medicine Ligands Lymphocytes T Male Medicine Medicine & Public Health Oncology p300-CBP Transcription Factors - antagonists & inhibitors p300-CBP Transcription Factors - genetics PD-L1 protein Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Small Molecule Libraries - pharmacology T cells T-Lymphocytes - immunology Tumor cells Wang, Chi γ-Interferon
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