Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

Severe coronavirus disease (COVID-19) is characterized by pulmonary hyper-inflammation and potentially life-threatening “cytokine storms”. Controlling the local and systemic inflammatory response in COVID-19 may be as important as anti-viral therapies. Endogenous lipid autacoid mediators, referred t...

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Veröffentlicht in:	Cancer and metastasis reviews 2020-06, Vol.39 (2), p.337-340
Hauptverfasser:	Panigrahy, Dipak, Gilligan, Molly M., Huang, Sui, Gartung, Allison, Cortés-Puch, Irene, Sime, Patricia J., Phipps, Richard P., Serhan, Charles N., Hammock, Bruce D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antiviral agents Antiviral Agents - therapeutic use Arachidonic acid Betacoronavirus - immunology Betacoronavirus - isolation & purification Biomedical and Life Sciences Biomedicine Cancer Research Cell death Clinical trials Clinical Trials as Topic Commentary Coronavirus Infections - complications Coronavirus Infections - drug therapy Coronavirus Infections - immunology Coronavirus Infections - virology Coronaviruses COVID-19 Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - immunology Cytokine storm Cytokines Cytokines - immunology Cytokines - metabolism Eicosanoids Eicosanoids - immunology Eicosanoids - metabolism Epoxide hydrolase Epoxide Hydrolases - antagonists & inhibitors Epoxide Hydrolases - metabolism Health aspects Humans Inflammation Inflammatory diseases Influenza Leukotrienes Lipids Lymphocytes B Macrophages Macrophages - immunology Macrophages - metabolism Oncology Pandemics Pneumonia, Viral - complications Pneumonia, Viral - drug therapy Pneumonia, Viral - immunology Pneumonia, Viral - virology Prostaglandins Pulmonary Alveoli - immunology Pulmonary Alveoli - metabolism Pulmonary Alveoli - virology Respiratory distress syndrome Respiratory Distress Syndrome - immunology Respiratory Distress Syndrome - therapy SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Staphylococcal enterotoxin H Storms Thrombosis Unsaturated fatty acids
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