Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting in basal or stress-induced turnover of cell components that provide energy and macromolecular precursors. These activities are thought to be particularly important in cancer where both tumor-promoting and t...
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| Veröffentlicht in: | Cell death and differentiation 2020-03, Vol.27 (3), p.843-857 |
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| creator | Mulcahy Levy, Jean M. Thorburn, Andrew |
| description | Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting in basal or stress-induced turnover of cell components that provide energy and macromolecular precursors. These activities are thought to be particularly important in cancer where both tumor-promoting and tumor-inhibiting functions of autophagy have been described. Autophagy has also been intricately linked to apoptosis and programmed cell death, and understanding these interactions is becoming increasingly important in improving cancer therapy and patient outcomes. In this review, we consider how recent discoveries about how autophagy manipulation elicits its effects on cancer cell behavior can be leveraged to improve therapeutic responses.
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| doi_str_mv | 10.1038/s41418-019-0474-7 |
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| subjects | 631/67 692/699/67 Animals Apoptosis Autophagy Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cell death Clinical Trials as Topic Humans Life Sciences Lysosomes Macromolecules Molecular Targeted Therapy Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Phagocytosis Review Review Article Stem Cells |
| title | Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients |
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