The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

Neuroblastoma is the most common extra-cranial pediatric solid tumor, responsible for 13–15% of pediatric cancer death. Its intrinsic heterogeneity makes it difficult to target for successful therapy. The adaptor protein p140Cap/SRCIN1 negatively regulates tumor cell features and limits breast cance...

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Veröffentlicht in:	Cell death and differentiation 2020-02, Vol.27 (2), p.790-807
Hauptverfasser:	Grasso, Silvia, Cangelosi, Davide, Chapelle, Jennifer, Alzona, Melissa, Centonze, Giorgia, Lamolinara, Alessia, Salemme, Vincenzo, Angelini, Costanza, Morellato, Alessandro, Saglietto, Andrea, Bianchi, Federico Tommaso, Cabodi, Sara, Salaroglio, Iris Chiara, Fusella, Federica, Ognibene, Marzia, Iezzi, Manuela, Pezzolo, Annalisa, Poli, Valeria, Di Cunto, Ferdinando, Eva, Alessandra, Riganti, Chiara, Varesio, Luigi, Turco, Emilia, Defilippi, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/2 13/44 13/51 13/89 13/95 14/63 38/39 38/61 45/91 631/337 631/67/2332 64/60 82/80 Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Animals Apoptosis Biochemistry Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Breast cancer Cell Biology Cell Cycle Analysis Cell Proliferation Cell Survival Chemotherapy Clonal deletion Cytotoxicity Doxorubicin Etoposide Gene deletion Heterozygosity Humans Infant Life Sciences Loss of heterozygosity Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Lung Neoplasms - secondary Male Metastases Mice Mice, Inbred NOD Mice, SCID mRNA Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neuroblastoma Neuroblastoma - diagnosis Neuroblastoma - metabolism Neuroblastoma cells Patients Pediatrics Proteins Risk factors Risk groups RNA, Messenger - genetics RNA, Messenger - metabolism Solid tumors Src protein Stat3 protein Stem Cells Tumor Cells, Cultured
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