Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

The antimalarial drug artemisinin and its derivatives have been explored as potential anticancer agents, but their underlying mechanisms are controversial. In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell death driven by iron...

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Veröffentlicht in:	Cell death and differentiation 2020-01, Vol.27 (1), p.242-254
Hauptverfasser:	Chen, Guo-Qing, Benthani, Fahad A., Wu, Jiao, Liang, Deguang, Bian, Zhao-Xiang, Jiang, Xuejun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/31 13/51 14/19 631/67 631/80 631/80/39 64/60 Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Artemisinin Artemisinins - chemistry Artemisinins - pharmacology Artemisinins - therapeutic use Autophagy - drug effects Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cell Line, Tumor Female Ferroptosis Ferroptosis - drug effects Homeostasis Humans Iron - metabolism Iron-Regulatory Proteins - metabolism Life Sciences Lysosomes - metabolism Mice, Nude Neoplasms - metabolism Response Elements Stem Cells Xenografts
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