Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma

Somatic oncogenic mutation of BRAF coupled with inactivation of PTEN constitute a frequent combination of genomic alterations driving the development of human melanoma. Mice genetically engineered to conditionally express oncogenic Braf V600E and inactivate Pten in melanocytes following tamoxifen tr...

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Veröffentlicht in:	Cell death and differentiation 2020-01, Vol.27 (1), p.29-43
Hauptverfasser:	Laurette, Patrick, Coassolo, Sébastien, Davidson, Guillaume, Michel, Isabelle, Gambi, Giovanni, Yao, Wenjin, Sohier, Pierre, Li, Mei, Mengus, Gabrielle, Larue, Lionel, Davidson, Irwin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 38/1 38/91 631/67/70 64/60 692/699/67/395 Animals Antigens, Nuclear - genetics Antigens, Nuclear - physiology Apoptosis Biochemistry Biomedical and Life Sciences BRG1 protein Cell Biology Cell Cycle Analysis Chromatin Disease Progression DNA Helicases - genetics DNA Helicases - physiology Epigenesis, Genetic Gene expression Gene Expression Regulation, Neoplastic Life Sciences Melanoma Melanoma, Experimental - genetics Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Microphthalmia-Associated Transcription Factor - genetics Microphthalmia-Associated Transcription Factor - metabolism Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Nuclear Proteins - genetics Nuclear Proteins - physiology Proto-Oncogene Proteins B-raf - genetics PTEN Phosphohydrolase - genetics RNA polymerase Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology SOXE Transcription Factors - genetics SOXE Transcription Factors - metabolism Stem Cells Transcription Factors - genetics Transcription Factors - physiology Tumor Cells, Cultured
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