Isopropyl‐phloroglucinol‐DHA protects outer retinal cells against lethal dose of all‐trans‐retinal

All‐trans‐retinal (atRAL) is a highly reactive carbonyl specie, known for its reactivity on cellular phosphatidylethanolamine in photoreceptor. It is generated by photoisomerization of 11‐cis‐retinal chromophore linked to opsin by the Schiff's base reaction. In ABCA4‐associated autosomal recess...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-05, Vol.24 (9), p.5057-5069
Hauptverfasser:	Cubizolle, Aurélie, Cia, David, Moine, Espérance, Jacquemot, Nathalie, Guillou, Laurent, Rosell, Mélissa, Angebault‐Prouteau, Claire, Lenaers, Guy, Meunier, Isabelle, Vercauteren, Joseph, Durand, Thierry, Crauste, Céline, Brabet, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	all‐trans‐retinal Animals Antioxidants Apoptosis bisretinoid A2E Carbonyl compounds carbonyl stress Catalase Cell culture Cell Line Cell Survival Chemical Sciences Chromophores Dehydroepiandrosterone Dystrophy Epithelium Fatty acids Humans isopropyl‐phloroglucinol‐DHA conjugate Lethal dose Light Lipofuscin Membranes Mice Mitochondria Neurons Organic chemistry Original outer retina cells Oxidative Stress Oxygen Phenol Phloroglucinol Phosphatidylethanolamine Photooxidation Photoreceptors Pigmentation Pigments Polyphenols Polyunsaturated fatty acids Protective Agents Rats Reactive Oxygen Species Respiration Retina Retinal Pigment Epithelium Retinaldehyde Retinoids Structure-Activity Relationship Toxicity
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