Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway in human colon cancer
The aim of the study was to research the biological functions of circRNA (hsa_circ_0079662) and its underlying mechanism in colorectal cancer. Drug‐resistant cell lines (HT29‐LOHP, HCT116‐LOHP, HCT8‐LOHP) were separately dealt with oxaliplatin concentration gradient (0.1‐10 μmol/L). Real‐time PCR, W...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2020-05, Vol.24 (9), p.5021-5027 |
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| creator | Lai, Mingfen Liu, Guiju Li, Ruijun Bai, Hua Zhao, Jizhi Xiao, Peng Mei, Jiazhuan |
| description | The aim of the study was to research the biological functions of circRNA (hsa_circ_0079662) and its underlying mechanism in colorectal cancer. Drug‐resistant cell lines (HT29‐LOHP, HCT116‐LOHP, HCT8‐LOHP) were separately dealt with oxaliplatin concentration gradient (0.1‐10 μmol/L). Real‐time PCR, Western blotting, dual‐luciferase assay, miRNA pull‐down assay, coimmunoprecipitation and ELASA were performed to explore the mechanism of chemotherapy drug oxaliplatin resistance in CRC. The results showed that the expression of hsa_circ_0079662 was increased in drug‐resistant cell lines by RT‐PCR. The expression of HOXA9, TRIP6, Vcam‐1, VEGFC, MMP3, MMP9 and MMP14 was higher by Western blotting. Interaction between HOXA9 and TRIP6 in CO‐IP detection. Additionally, the cytokines TNF‐α, IL‐1 and IL‐6 were also found. In conclusion, hsa_circ_0079662, as a ceRNA binding with hsa‐mir‐324‐5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF‐α pathway in human colon cancer. |
| doi_str_mv | 10.1111/jcmm.15122 |
| format | Article |
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Drug‐resistant cell lines (HT29‐LOHP, HCT116‐LOHP, HCT8‐LOHP) were separately dealt with oxaliplatin concentration gradient (0.1‐10 μmol/L). Real‐time PCR, Western blotting, dual‐luciferase assay, miRNA pull‐down assay, coimmunoprecipitation and ELASA were performed to explore the mechanism of chemotherapy drug oxaliplatin resistance in CRC. The results showed that the expression of hsa_circ_0079662 was increased in drug‐resistant cell lines by RT‐PCR. The expression of HOXA9, TRIP6, Vcam‐1, VEGFC, MMP3, MMP9 and MMP14 was higher by Western blotting. Interaction between HOXA9 and TRIP6 in CO‐IP detection. Additionally, the cytokines TNF‐α, IL‐1 and IL‐6 were also found. In conclusion, hsa_circ_0079662, as a ceRNA binding with hsa‐mir‐324‐5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF‐α pathway in human colon cancer.</description><identifier>ISSN: 1582-1838</identifier><identifier>ISSN: 1582-4934</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.15122</identifier><identifier>PMID: 32243061</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Binding sites ; Cell culture ; Cell growth ; Cell Line, Tumor ; ceRNA ; Chemotherapy ; Chromosome 5 ; Colon cancer ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - genetics ; Colorectal cancer ; Colorectal carcinoma ; Cytokines ; Drug resistance ; Drug Resistance, Neoplasm ; Flow cytometry ; Gelatinase B ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Homeodomain Proteins - biosynthesis ; HOXA9 ; Hsa_circ_0079662 ; HT29 Cells ; Humans ; In Situ Hybridization, Fluorescence ; Metastasis ; Mice ; Mice, Nude ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Neoplasm Transplantation ; Original ; Oxaliplatin ; Oxaliplatin - pharmacology ; Protein expression ; Proteins ; RNA, Circular ; TNF‐α pathway ; Tumor cell lines ; Tumor Necrosis Factor-alpha - biosynthesis ; Veins & arteries ; Western blotting</subject><ispartof>Journal of cellular and molecular medicine, 2020-05, Vol.24 (9), p.5021-5027</ispartof><rights>2020 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd</rights><rights>2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4482-5aa4ddf3bdd1c39eae352d2efee83588392de8db9968af8bab88dd2804ffa39b3</citedby><cites>FETCH-LOGICAL-c4482-5aa4ddf3bdd1c39eae352d2efee83588392de8db9968af8bab88dd2804ffa39b3</cites><orcidid>0000-0002-1040-643X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205783/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205783/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32243061$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Mingfen</creatorcontrib><creatorcontrib>Liu, Guiju</creatorcontrib><creatorcontrib>Li, Ruijun</creatorcontrib><creatorcontrib>Bai, Hua</creatorcontrib><creatorcontrib>Zhao, Jizhi</creatorcontrib><creatorcontrib>Xiao, Peng</creatorcontrib><creatorcontrib>Mei, Jiazhuan</creatorcontrib><title>Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway in human colon cancer</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>The aim of the study was to research the biological functions of circRNA (hsa_circ_0079662) and its underlying mechanism in colorectal cancer. Drug‐resistant cell lines (HT29‐LOHP, HCT116‐LOHP, HCT8‐LOHP) were separately dealt with oxaliplatin concentration gradient (0.1‐10 μmol/L). Real‐time PCR, Western blotting, dual‐luciferase assay, miRNA pull‐down assay, coimmunoprecipitation and ELASA were performed to explore the mechanism of chemotherapy drug oxaliplatin resistance in CRC. The results showed that the expression of hsa_circ_0079662 was increased in drug‐resistant cell lines by RT‐PCR. The expression of HOXA9, TRIP6, Vcam‐1, VEGFC, MMP3, MMP9 and MMP14 was higher by Western blotting. Interaction between HOXA9 and TRIP6 in CO‐IP detection. Additionally, the cytokines TNF‐α, IL‐1 and IL‐6 were also found. In conclusion, hsa_circ_0079662, as a ceRNA binding with hsa‐mir‐324‐5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF‐α pathway in human colon cancer.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Binding sites</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>ceRNA</subject><subject>Chemotherapy</subject><subject>Chromosome 5</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Cytokines</subject><subject>Drug resistance</subject><subject>Drug Resistance, Neoplasm</subject><subject>Flow cytometry</subject><subject>Gelatinase B</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>HCT116 Cells</subject><subject>Homeodomain Proteins - biosynthesis</subject><subject>HOXA9</subject><subject>Hsa_circ_0079662</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Neoplasm Transplantation</subject><subject>Original</subject><subject>Oxaliplatin</subject><subject>Oxaliplatin - pharmacology</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>RNA, Circular</subject><subject>TNF‐α pathway</subject><subject>Tumor cell lines</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Veins & arteries</subject><subject>Western blotting</subject><issn>1582-1838</issn><issn>1582-4934</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9u1DAQxiMEoqVw4QGQJS4IaVv_S9a5IFUrSkFtuZSzNbEnG6-SONgJZW9cufEqvAgP0Sep9w8VcMCH8Ujz0_fN6Muy54wes_ROVqbrjlnOOH-QHbJc8ZkshXy475kS6iB7EuOKUlEwUT7ODgTnUtCCHWbfzyNo44LRlM7LouDE9XYyGMnYIAkYXRyhN0g6NA30LnbE19uZabDzqQkwrIkN05L4r9C6oYXR9YkIflo2W_L66uz2249fP8kAY3MD62RBmqmDnhjf-lQ3BuFp9qiGNuKz_X-UfTp7e704n118fPd-cXoxM1Kmc3IAaW0tKmuZESUCipxbjjWiErlSouQWla3KslBQqwoqpazlisq6BlFW4ih7s9MdpqpDa7AfA7R6CK6DsNYenP570rtGL_0XPec0nyuRBF7tBYL_PGEcdeeiwbaFHv0UNReqSH4lVwl9-Q-68lPo03maF0wxwbiUiXq9o0zwMQas75dhVG8S1puE9TbhBL_4c_179HekCWA74Ma1uP6PlP6wuLzcid4BDwK1rw</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Lai, Mingfen</creator><creator>Liu, Guiju</creator><creator>Li, Ruijun</creator><creator>Bai, Hua</creator><creator>Zhao, Jizhi</creator><creator>Xiao, Peng</creator><creator>Mei, Jiazhuan</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1040-643X</orcidid></search><sort><creationdate>202005</creationdate><title>Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway in human colon cancer</title><author>Lai, Mingfen ; Liu, Guiju ; Li, Ruijun ; Bai, Hua ; Zhao, Jizhi ; Xiao, Peng ; Mei, Jiazhuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4482-5aa4ddf3bdd1c39eae352d2efee83588392de8db9968af8bab88dd2804ffa39b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Binding sites</topic><topic>Cell culture</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>ceRNA</topic><topic>Chemotherapy</topic><topic>Chromosome 5</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Cytokines</topic><topic>Drug resistance</topic><topic>Drug Resistance, Neoplasm</topic><topic>Flow cytometry</topic><topic>Gelatinase B</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>HCT116 Cells</topic><topic>Homeodomain Proteins - biosynthesis</topic><topic>HOXA9</topic><topic>Hsa_circ_0079662</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>Neoplasm Transplantation</topic><topic>Original</topic><topic>Oxaliplatin</topic><topic>Oxaliplatin - pharmacology</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>RNA, Circular</topic><topic>TNF‐α pathway</topic><topic>Tumor cell lines</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Veins & arteries</topic><topic>Western blotting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Mingfen</creatorcontrib><creatorcontrib>Liu, Guiju</creatorcontrib><creatorcontrib>Li, Ruijun</creatorcontrib><creatorcontrib>Bai, Hua</creatorcontrib><creatorcontrib>Zhao, Jizhi</creatorcontrib><creatorcontrib>Xiao, Peng</creatorcontrib><creatorcontrib>Mei, Jiazhuan</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Mingfen</au><au>Liu, Guiju</au><au>Li, Ruijun</au><au>Bai, Hua</au><au>Zhao, Jizhi</au><au>Xiao, Peng</au><au>Mei, Jiazhuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway in human colon cancer</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2020-05</date><risdate>2020</risdate><volume>24</volume><issue>9</issue><spage>5021</spage><epage>5027</epage><pages>5021-5027</pages><issn>1582-1838</issn><issn>1582-4934</issn><eissn>1582-4934</eissn><abstract>The aim of the study was to research the biological functions of circRNA (hsa_circ_0079662) and its underlying mechanism in colorectal cancer. Drug‐resistant cell lines (HT29‐LOHP, HCT116‐LOHP, HCT8‐LOHP) were separately dealt with oxaliplatin concentration gradient (0.1‐10 μmol/L). Real‐time PCR, Western blotting, dual‐luciferase assay, miRNA pull‐down assay, coimmunoprecipitation and ELASA were performed to explore the mechanism of chemotherapy drug oxaliplatin resistance in CRC. The results showed that the expression of hsa_circ_0079662 was increased in drug‐resistant cell lines by RT‐PCR. The expression of HOXA9, TRIP6, Vcam‐1, VEGFC, MMP3, MMP9 and MMP14 was higher by Western blotting. Interaction between HOXA9 and TRIP6 in CO‐IP detection. Additionally, the cytokines TNF‐α, IL‐1 and IL‐6 were also found. In conclusion, hsa_circ_0079662, as a ceRNA binding with hsa‐mir‐324‐5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF‐α pathway in human colon cancer.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>32243061</pmid><doi>10.1111/jcmm.15122</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1040-643X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Binding sites Cell culture Cell growth Cell Line, Tumor ceRNA Chemotherapy Chromosome 5 Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colorectal cancer Colorectal carcinoma Cytokines Drug resistance Drug Resistance, Neoplasm Flow cytometry Gelatinase B Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic HCT116 Cells Homeodomain Proteins - biosynthesis HOXA9 Hsa_circ_0079662 HT29 Cells Humans In Situ Hybridization, Fluorescence Metastasis Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miRNA Neoplasm Transplantation Original Oxaliplatin Oxaliplatin - pharmacology Protein expression Proteins RNA, Circular TNF‐α pathway Tumor cell lines Tumor Necrosis Factor-alpha - biosynthesis Veins & arteries Western blotting |
| title | Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway in human colon cancer |
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