Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway

•Licorice defect in TCM recipes leads to the hepatotoxicity in administrated mice.•GA inhibits viral hepatitis by suppressing HMGB1 release and cytokine activity.•GA treatment effect on infected mice is similar with HMGB1 neutralizing antibody.•HMGB1-TLR4 axis is involved in murine hepatic injury du...

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Veröffentlicht in:	International immunopharmacology 2020-07, Vol.84, p.106578-106578, Article 106578
Hauptverfasser:	Shi, Xiaodong, Yu, Lijia, Zhang, Yinglin, Liu, Zequan, Zhang, Huawei, Zhang, Yansong, Liu, Ping, Du, Peishuang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antibodies Cell Line Cytokine storm Cytokines Cytokines - genetics Detoxification Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Female Glycyrrhetinic acid Glycyrrhetinic Acid - pharmacology Glycyrrhetinic Acid - therapeutic use Glycyrrhiza Health services Hepatic injury Hepatitis Hepatitis, Viral, Animal - drug therapy Hepatitis, Viral, Animal - genetics Hepatitis, Viral, Animal - immunology Herbal medicine HMGB1 HMGB1 protein HMGB1 Protein - immunology Immunology Infectious diseases Inflammatory diseases Injuries Liver - drug effects Liver - immunology Liver diseases Medical treatment MHV Mice, Inbred C57BL Mice, Knockout Murine hepatitis virus Signal transduction Signal Transduction - drug effects Signaling TLR4 TLR4 protein Toll-Like Receptor 4 - genetics Toll-like receptors Viruses
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