Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome
Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a b...
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| Veröffentlicht in: | Internal Medicine 2020/04/15, Vol.59(8), pp.1081-1086 |
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| creator | Hashimoto, Miki Itonaga, Hidehiro Nannya, Yasuhito Taniguchi, Hirokazu Fukuda, Yuichi Furumoto, Takafumi Fujioka, Machiko Kasai, Sachie Taguchi, Masataka Taniguchi, Hiroaki Sato, Shinya Sawayama, Yasushi Atogami, Sunao Iwasaki, Keisuke Hata, Tomoko Soda, Hiroshi Moriuchi, Yukiyoshi Nakata, Koh Ogawa, Seishi Miyazaki, Yasushi |
| description | Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment. |
| doi_str_mv | 10.2169/internalmedicine.3770-19 |
| format | Article |
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A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.3770-19</identifier><identifier>PMID: 31875636</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>azacitidine ; Biopsy ; Bone marrow ; Case Report ; Computed tomography ; Diagnosis ; Internal medicine ; Myelodysplastic syndrome ; myelodysplastic syndromes ; Pulmonary lesions ; secondary pulmonary alveolar proteinosis ; umbilical cord blood transplantation</subject><ispartof>Internal Medicine, 2020/04/15, Vol.59(8), pp.1081-1086</ispartof><rights>2020 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2020</rights><rights>Copyright © 2020 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-98af7c738b909d6228c42c5e6c64039edc6b427fc9201cd5a89b1313adb5d3eb3</citedby><cites>FETCH-LOGICAL-c653t-98af7c738b909d6228c42c5e6c64039edc6b427fc9201cd5a89b1313adb5d3eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205539/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205539/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31875636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashimoto, Miki</creatorcontrib><creatorcontrib>Itonaga, Hidehiro</creatorcontrib><creatorcontrib>Nannya, Yasuhito</creatorcontrib><creatorcontrib>Taniguchi, Hirokazu</creatorcontrib><creatorcontrib>Fukuda, Yuichi</creatorcontrib><creatorcontrib>Furumoto, Takafumi</creatorcontrib><creatorcontrib>Fujioka, Machiko</creatorcontrib><creatorcontrib>Kasai, Sachie</creatorcontrib><creatorcontrib>Taguchi, Masataka</creatorcontrib><creatorcontrib>Taniguchi, Hiroaki</creatorcontrib><creatorcontrib>Sato, Shinya</creatorcontrib><creatorcontrib>Sawayama, Yasushi</creatorcontrib><creatorcontrib>Atogami, Sunao</creatorcontrib><creatorcontrib>Iwasaki, Keisuke</creatorcontrib><creatorcontrib>Hata, Tomoko</creatorcontrib><creatorcontrib>Soda, Hiroshi</creatorcontrib><creatorcontrib>Moriuchi, Yukiyoshi</creatorcontrib><creatorcontrib>Nakata, Koh</creatorcontrib><creatorcontrib>Ogawa, Seishi</creatorcontrib><creatorcontrib>Miyazaki, Yasushi</creatorcontrib><title>Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.</description><subject>azacitidine</subject><subject>Biopsy</subject><subject>Bone marrow</subject><subject>Case Report</subject><subject>Computed tomography</subject><subject>Diagnosis</subject><subject>Internal medicine</subject><subject>Myelodysplastic syndrome</subject><subject>myelodysplastic syndromes</subject><subject>Pulmonary lesions</subject><subject>secondary pulmonary alveolar proteinosis</subject><subject>umbilical cord blood transplantation</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNplkVtvEzEQhS0EoiHwF9BKvPCyrS97sV-QoqoFpAKVWp4tr3c2ceS1g-1tFX49XiWNoLyMLfnzmTNzECoIPqekERfGJQhO2RF6o42Dc9a2uCTiBVoQVomypax-iRZYEF7SXM7Qmxi3GDPeCvoanTHC27phzQJt70B716uwL24nO3o331b2AbxVobgNPoFxPppYXHtr_aNx6-I-gEojuFQ8mrQpVr-VNsn02Ucx-FB824P1_T7urIrJ6OJu7_rgR3iLXg3KRnh3PJfo5_XV_eWX8ubH56-Xq5tSNzVLpeBqaHXLeCew6BtKua6orqHRTYWZgF43XUXbQQuKie5rxUVHGGGq7-qeQceW6NNBdzd1eUE6Gw3Kyl0wYx5OemXkvy_ObOTaP8iW4rpmIgt8PAoE_2uCmORoogZrlQM_RUkZw3mPVbazRB-eoVs_zcnMlGhpjTnnmeIHSgcfY4DhZIZgOQcqnwcq50Almb28_3uY08enBDPw_QBsY1JrOAEq5N1b-F-5FpLP5djhBOqNChIc-wMsFcKU</recordid><startdate>20200415</startdate><enddate>20200415</enddate><creator>Hashimoto, Miki</creator><creator>Itonaga, Hidehiro</creator><creator>Nannya, Yasuhito</creator><creator>Taniguchi, Hirokazu</creator><creator>Fukuda, Yuichi</creator><creator>Furumoto, Takafumi</creator><creator>Fujioka, Machiko</creator><creator>Kasai, Sachie</creator><creator>Taguchi, Masataka</creator><creator>Taniguchi, Hiroaki</creator><creator>Sato, Shinya</creator><creator>Sawayama, Yasushi</creator><creator>Atogami, Sunao</creator><creator>Iwasaki, Keisuke</creator><creator>Hata, Tomoko</creator><creator>Soda, Hiroshi</creator><creator>Moriuchi, Yukiyoshi</creator><creator>Nakata, Koh</creator><creator>Ogawa, Seishi</creator><creator>Miyazaki, Yasushi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200415</creationdate><title>Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome</title><author>Hashimoto, Miki ; Itonaga, Hidehiro ; Nannya, Yasuhito ; Taniguchi, Hirokazu ; Fukuda, Yuichi ; Furumoto, Takafumi ; Fujioka, Machiko ; Kasai, Sachie ; Taguchi, Masataka ; Taniguchi, Hiroaki ; Sato, Shinya ; Sawayama, Yasushi ; Atogami, Sunao ; Iwasaki, Keisuke ; Hata, Tomoko ; Soda, Hiroshi ; Moriuchi, Yukiyoshi ; Nakata, Koh ; Ogawa, Seishi ; Miyazaki, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-98af7c738b909d6228c42c5e6c64039edc6b427fc9201cd5a89b1313adb5d3eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>azacitidine</topic><topic>Biopsy</topic><topic>Bone marrow</topic><topic>Case Report</topic><topic>Computed tomography</topic><topic>Diagnosis</topic><topic>Internal medicine</topic><topic>Myelodysplastic syndrome</topic><topic>myelodysplastic syndromes</topic><topic>Pulmonary lesions</topic><topic>secondary pulmonary alveolar proteinosis</topic><topic>umbilical cord blood transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashimoto, Miki</creatorcontrib><creatorcontrib>Itonaga, Hidehiro</creatorcontrib><creatorcontrib>Nannya, Yasuhito</creatorcontrib><creatorcontrib>Taniguchi, Hirokazu</creatorcontrib><creatorcontrib>Fukuda, Yuichi</creatorcontrib><creatorcontrib>Furumoto, Takafumi</creatorcontrib><creatorcontrib>Fujioka, Machiko</creatorcontrib><creatorcontrib>Kasai, Sachie</creatorcontrib><creatorcontrib>Taguchi, Masataka</creatorcontrib><creatorcontrib>Taniguchi, Hiroaki</creatorcontrib><creatorcontrib>Sato, Shinya</creatorcontrib><creatorcontrib>Sawayama, Yasushi</creatorcontrib><creatorcontrib>Atogami, Sunao</creatorcontrib><creatorcontrib>Iwasaki, Keisuke</creatorcontrib><creatorcontrib>Hata, Tomoko</creatorcontrib><creatorcontrib>Soda, Hiroshi</creatorcontrib><creatorcontrib>Moriuchi, Yukiyoshi</creatorcontrib><creatorcontrib>Nakata, Koh</creatorcontrib><creatorcontrib>Ogawa, Seishi</creatorcontrib><creatorcontrib>Miyazaki, Yasushi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashimoto, Miki</au><au>Itonaga, Hidehiro</au><au>Nannya, Yasuhito</au><au>Taniguchi, Hirokazu</au><au>Fukuda, Yuichi</au><au>Furumoto, Takafumi</au><au>Fujioka, Machiko</au><au>Kasai, Sachie</au><au>Taguchi, Masataka</au><au>Taniguchi, Hiroaki</au><au>Sato, Shinya</au><au>Sawayama, Yasushi</au><au>Atogami, Sunao</au><au>Iwasaki, Keisuke</au><au>Hata, Tomoko</au><au>Soda, Hiroshi</au><au>Moriuchi, Yukiyoshi</au><au>Nakata, Koh</au><au>Ogawa, Seishi</au><au>Miyazaki, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2020-04-15</date><risdate>2020</risdate><volume>59</volume><issue>8</issue><spage>1081</spage><epage>1086</epage><pages>1081-1086</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Secondary pulmonary alveolar proteinosis (sPAP) is a complication of myelodysplastic syndrome (MDS). A 60-year-old woman was diagnosed with MDS with excess blasts-1. Fifty-four months after the initial diagnosis, treatment with azacitidine was initiated. Seventy-three months after the diagnosis, a bone marrow examination revealed increased myeloblasts, at which time computed tomography showed diffuse ground-glass opacities and interlobular septal thickening in the bilateral lower lung fields. A lung biopsy revealed the presence of PAP; therefore, the clinical diagnosis of MDS/sPAP was confirmed. Careful attention should be paid to the development of sPAP in MDS patients with pulmonary lesions during azacitidine treatment.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>31875636</pmid><doi>10.2169/internalmedicine.3770-19</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | azacitidine Biopsy Bone marrow Case Report Computed tomography Diagnosis Internal medicine Myelodysplastic syndrome myelodysplastic syndromes Pulmonary lesions secondary pulmonary alveolar proteinosis umbilical cord blood transplantation |
| title | Secondary Pulmonary Alveolar Proteinosis Following Treatment with Azacitidine for Myelodysplastic Syndrome |
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