The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis

In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation patterns have remained unknown. Using deep bisulfite sequencing (DBS), we screened swim...

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