T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES)
Background The T.sub.1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T.sub.1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T.sub.1 measurement repeat...
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| creator | Captur, Gabriella Bhandari, Abhiyan Brühl, Rüdiger Ittermann, Bernd Keenan, Kathryn E Yang, Ye Eames, Richard J Benedetti, Giulia Torlasco, Camilla Ricketts, Lewis Boubertakh, Redha Fatih, Nasri Greenwood, John P Paulis, Leonie E. M Lawton, Chris B Bucciarelli-Ducci, Chiara Lamb, Hildo J Steeds, Richard Leung, Steve W Berry, Colin Valentin, Sinitsyn Flett, Andrew de Lange, Charlotte DeCobelli, Francesco Viallon, Magalie Croisille, Pierre Higgins, David M Greiser, Andreas Pang, Wenjie Hamilton-Craig, Christian Strugnell, Wendy E Dresselaers, Tom Barison, Andrea Dawson, Dana Taylor, Andrew J Mongeon, François-Pierre Plein, Sven Messroghli, Daniel Al-Mallah, Mouaz Grieve, Stuart M Lombardi, Massimo Jang, Jihye Salerno, Michael Chaturvedi, Nish Kellman, Peter Bluemke, David A Nezafat, Reza Gatehouse, Peter Moon, James C |
| description | Background The T.sub.1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T.sub.1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T.sub.1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B.sub.0 and B.sub.1, and "reference" slow T.sub.1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T.sub.1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5 T and 22 3 T magnets using multiple T.sub.1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T.sub.1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T.sub.1 variation. Results Over 2 years, phantom gel integrity remained intact (no rips/tears), B.sub.0 and B.sub.1 homogenous, and "reference" T.sub.1 stable compared to baseline (% change at 1.5 T, 1.95 [+ or -] 1.39%; 3 T, 2.22 [+ or -] 1.44%). Per degrees Celsius, 1.5 T, T.sub.1 (MOLLI 5s(3s)3s) increased by 11.4 ms in long native blood tubes and decreased by 1.2 ms in short post-contrast myocardium tubes. Agreement of estimated T.sub.1 times with "reference" T.sub.1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R.sup.2 ranges for both field strengths, 0.99-1.00). Over 1 year, many 1.5 T and 3 T sequences/magnets were repeatable with mean CoVs < 1 and 2% respectively. Repeatability was narrower for 1.5 T over 3 T. Within T1MES repeatability for native T.sub.1 was narrow for several sequences, for example, at 1.5 T, Siemens MOLLI 5s(3s)3s prototype number 448B (mean CoV = 0.27%) and Philips modified Look-Locker inversion recovery (MOLLI) 3s(3s)5s (CoV 0.54%), and at 3 T, Philips MOLLI 3b(3s)5b (CoV 0.33%) and Siemens shortened MOLLI (ShMOLLI) prototype 780C (CoV 0.69%). After adjusting for temperature and field strength, it was found that the T.sub.1 mapping sequence and scanner software version (both P < 0.001 at 1.5 T and 3 T), and to a lesser extent the scanner model (P = |
| doi_str_mv | 10.1186/s12968-020-00613-3 |
| format | Article |
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M ; Lawton, Chris B ; Bucciarelli-Ducci, Chiara ; Lamb, Hildo J ; Steeds, Richard ; Leung, Steve W ; Berry, Colin ; Valentin, Sinitsyn ; Flett, Andrew ; de Lange, Charlotte ; DeCobelli, Francesco ; Viallon, Magalie ; Croisille, Pierre ; Higgins, David M ; Greiser, Andreas ; Pang, Wenjie ; Hamilton-Craig, Christian ; Strugnell, Wendy E ; Dresselaers, Tom ; Barison, Andrea ; Dawson, Dana ; Taylor, Andrew J ; Mongeon, François-Pierre ; Plein, Sven ; Messroghli, Daniel ; Al-Mallah, Mouaz ; Grieve, Stuart M ; Lombardi, Massimo ; Jang, Jihye ; Salerno, Michael ; Chaturvedi, Nish ; Kellman, Peter ; Bluemke, David A ; Nezafat, Reza ; Gatehouse, Peter ; Moon, James C</creator><creatorcontrib>Captur, Gabriella ; Bhandari, Abhiyan ; Brühl, Rüdiger ; Ittermann, Bernd ; Keenan, Kathryn E ; Yang, Ye ; Eames, Richard J ; Benedetti, Giulia ; Torlasco, Camilla ; Ricketts, Lewis ; Boubertakh, Redha ; Fatih, Nasri ; Greenwood, John P ; Paulis, Leonie E. M ; Lawton, Chris B ; Bucciarelli-Ducci, Chiara ; Lamb, Hildo J ; Steeds, Richard ; Leung, Steve W ; Berry, Colin ; Valentin, Sinitsyn ; Flett, Andrew ; de Lange, Charlotte ; DeCobelli, Francesco ; Viallon, Magalie ; Croisille, Pierre ; Higgins, David M ; Greiser, Andreas ; Pang, Wenjie ; Hamilton-Craig, Christian ; Strugnell, Wendy E ; Dresselaers, Tom ; Barison, Andrea ; Dawson, Dana ; Taylor, Andrew J ; Mongeon, François-Pierre ; Plein, Sven ; Messroghli, Daniel ; Al-Mallah, Mouaz ; Grieve, Stuart M ; Lombardi, Massimo ; Jang, Jihye ; Salerno, Michael ; Chaturvedi, Nish ; Kellman, Peter ; Bluemke, David A ; Nezafat, Reza ; Gatehouse, Peter ; Moon, James C</creatorcontrib><description>Background The T.sub.1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T.sub.1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T.sub.1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B.sub.0 and B.sub.1, and "reference" slow T.sub.1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T.sub.1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5 T and 22 3 T magnets using multiple T.sub.1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T.sub.1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T.sub.1 variation. Results Over 2 years, phantom gel integrity remained intact (no rips/tears), B.sub.0 and B.sub.1 homogenous, and "reference" T.sub.1 stable compared to baseline (% change at 1.5 T, 1.95 [+ or -] 1.39%; 3 T, 2.22 [+ or -] 1.44%). Per degrees Celsius, 1.5 T, T.sub.1 (MOLLI 5s(3s)3s) increased by 11.4 ms in long native blood tubes and decreased by 1.2 ms in short post-contrast myocardium tubes. Agreement of estimated T.sub.1 times with "reference" T.sub.1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R.sup.2 ranges for both field strengths, 0.99-1.00). Over 1 year, many 1.5 T and 3 T sequences/magnets were repeatable with mean CoVs < 1 and 2% respectively. Repeatability was narrower for 1.5 T over 3 T. Within T1MES repeatability for native T.sub.1 was narrow for several sequences, for example, at 1.5 T, Siemens MOLLI 5s(3s)3s prototype number 448B (mean CoV = 0.27%) and Philips modified Look-Locker inversion recovery (MOLLI) 3s(3s)5s (CoV 0.54%), and at 3 T, Philips MOLLI 3b(3s)5b (CoV 0.33%) and Siemens shortened MOLLI (ShMOLLI) prototype 780C (CoV 0.69%). After adjusting for temperature and field strength, it was found that the T.sub.1 mapping sequence and scanner software version (both P < 0.001 at 1.5 T and 3 T), and to a lesser extent the scanner model (P = 0.011, 1.5 T only), had the greatest influence on T.sub.1 across multiple centers. Conclusion The T1MES CE/FDA approved phantom is a robust quality assurance device. In a multi-center setting, T.sub.1 mapping had performance differences between field strengths, sequences, scanner software versions, and manufacturers. However, several specific combinations of field strength, sequence, and scanner are highly repeatable, and thus, have potential to provide standardized assessment of T.sub.1 times for clinical use, although temperature correction is required for native T.sub.1 tubes at least. Keywords: T.sub.1 mapping, Standardization, Calibration, Phantom, Repeatability, Extracellular volume</description><identifier>ISSN: 1097-6647</identifier><identifier>EISSN: 1532-429X</identifier><identifier>DOI: 10.1186/s12968-020-00613-3</identifier><identifier>PMID: 32375896</identifier><language>eng</language><publisher>New York: BioMed Central Ltd</publisher><subject>Biomarkers ; Coefficient of variation ; Computer programs ; Datasets ; Electric equipment industry ; Field strength ; Laboratories ; Life Sciences ; Magnets ; Mapping ; Measurement ; Myocardium ; Prototypes ; Quality assurance ; Quality control ; Quality standards ; Regulatory agencies ; Regulatory sequences ; Reproducibility ; Resistance thermometers ; Scanners ; Software ; Standardization ; Statistical analysis ; Temperature dependence ; Temperature requirements ; Tubes ; Values</subject><ispartof>Journal of cardiovascular magnetic resonance, 2020-05, Vol.22 (1), p.31-31, Article 31</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-f593df5c3d61d4ef54a1092a303c012cddb7f2d459903b214fe78708c89cded03</citedby><cites>FETCH-LOGICAL-c469t-f593df5c3d61d4ef54a1092a303c012cddb7f2d459903b214fe78708c89cded03</cites><orcidid>0000-0002-3662-3846 ; 0000-0001-9118-0438</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204222/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204222/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03129200$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Captur, Gabriella</creatorcontrib><creatorcontrib>Bhandari, Abhiyan</creatorcontrib><creatorcontrib>Brühl, Rüdiger</creatorcontrib><creatorcontrib>Ittermann, Bernd</creatorcontrib><creatorcontrib>Keenan, Kathryn E</creatorcontrib><creatorcontrib>Yang, Ye</creatorcontrib><creatorcontrib>Eames, Richard J</creatorcontrib><creatorcontrib>Benedetti, Giulia</creatorcontrib><creatorcontrib>Torlasco, Camilla</creatorcontrib><creatorcontrib>Ricketts, Lewis</creatorcontrib><creatorcontrib>Boubertakh, Redha</creatorcontrib><creatorcontrib>Fatih, Nasri</creatorcontrib><creatorcontrib>Greenwood, John P</creatorcontrib><creatorcontrib>Paulis, Leonie E. M</creatorcontrib><creatorcontrib>Lawton, Chris B</creatorcontrib><creatorcontrib>Bucciarelli-Ducci, Chiara</creatorcontrib><creatorcontrib>Lamb, Hildo J</creatorcontrib><creatorcontrib>Steeds, Richard</creatorcontrib><creatorcontrib>Leung, Steve W</creatorcontrib><creatorcontrib>Berry, Colin</creatorcontrib><creatorcontrib>Valentin, Sinitsyn</creatorcontrib><creatorcontrib>Flett, Andrew</creatorcontrib><creatorcontrib>de Lange, Charlotte</creatorcontrib><creatorcontrib>DeCobelli, Francesco</creatorcontrib><creatorcontrib>Viallon, Magalie</creatorcontrib><creatorcontrib>Croisille, Pierre</creatorcontrib><creatorcontrib>Higgins, David M</creatorcontrib><creatorcontrib>Greiser, Andreas</creatorcontrib><creatorcontrib>Pang, Wenjie</creatorcontrib><creatorcontrib>Hamilton-Craig, Christian</creatorcontrib><creatorcontrib>Strugnell, Wendy E</creatorcontrib><creatorcontrib>Dresselaers, Tom</creatorcontrib><creatorcontrib>Barison, Andrea</creatorcontrib><creatorcontrib>Dawson, Dana</creatorcontrib><creatorcontrib>Taylor, Andrew J</creatorcontrib><creatorcontrib>Mongeon, François-Pierre</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Messroghli, Daniel</creatorcontrib><creatorcontrib>Al-Mallah, Mouaz</creatorcontrib><creatorcontrib>Grieve, Stuart M</creatorcontrib><creatorcontrib>Lombardi, Massimo</creatorcontrib><creatorcontrib>Jang, Jihye</creatorcontrib><creatorcontrib>Salerno, Michael</creatorcontrib><creatorcontrib>Chaturvedi, Nish</creatorcontrib><creatorcontrib>Kellman, Peter</creatorcontrib><creatorcontrib>Bluemke, David A</creatorcontrib><creatorcontrib>Nezafat, Reza</creatorcontrib><creatorcontrib>Gatehouse, Peter</creatorcontrib><creatorcontrib>Moon, James C</creatorcontrib><title>T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES)</title><title>Journal of cardiovascular magnetic resonance</title><description>Background The T.sub.1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T.sub.1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T.sub.1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B.sub.0 and B.sub.1, and "reference" slow T.sub.1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T.sub.1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5 T and 22 3 T magnets using multiple T.sub.1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T.sub.1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T.sub.1 variation. Results Over 2 years, phantom gel integrity remained intact (no rips/tears), B.sub.0 and B.sub.1 homogenous, and "reference" T.sub.1 stable compared to baseline (% change at 1.5 T, 1.95 [+ or -] 1.39%; 3 T, 2.22 [+ or -] 1.44%). Per degrees Celsius, 1.5 T, T.sub.1 (MOLLI 5s(3s)3s) increased by 11.4 ms in long native blood tubes and decreased by 1.2 ms in short post-contrast myocardium tubes. Agreement of estimated T.sub.1 times with "reference" T.sub.1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R.sup.2 ranges for both field strengths, 0.99-1.00). Over 1 year, many 1.5 T and 3 T sequences/magnets were repeatable with mean CoVs < 1 and 2% respectively. Repeatability was narrower for 1.5 T over 3 T. Within T1MES repeatability for native T.sub.1 was narrow for several sequences, for example, at 1.5 T, Siemens MOLLI 5s(3s)3s prototype number 448B (mean CoV = 0.27%) and Philips modified Look-Locker inversion recovery (MOLLI) 3s(3s)5s (CoV 0.54%), and at 3 T, Philips MOLLI 3b(3s)5b (CoV 0.33%) and Siemens shortened MOLLI (ShMOLLI) prototype 780C (CoV 0.69%). After adjusting for temperature and field strength, it was found that the T.sub.1 mapping sequence and scanner software version (both P < 0.001 at 1.5 T and 3 T), and to a lesser extent the scanner model (P = 0.011, 1.5 T only), had the greatest influence on T.sub.1 across multiple centers. Conclusion The T1MES CE/FDA approved phantom is a robust quality assurance device. In a multi-center setting, T.sub.1 mapping had performance differences between field strengths, sequences, scanner software versions, and manufacturers. However, several specific combinations of field strength, sequence, and scanner are highly repeatable, and thus, have potential to provide standardized assessment of T.sub.1 times for clinical use, although temperature correction is required for native T.sub.1 tubes at least. Keywords: T.sub.1 mapping, Standardization, Calibration, Phantom, Repeatability, Extracellular volume</description><subject>Biomarkers</subject><subject>Coefficient of variation</subject><subject>Computer programs</subject><subject>Datasets</subject><subject>Electric equipment industry</subject><subject>Field strength</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Magnets</subject><subject>Mapping</subject><subject>Measurement</subject><subject>Myocardium</subject><subject>Prototypes</subject><subject>Quality assurance</subject><subject>Quality control</subject><subject>Quality standards</subject><subject>Regulatory agencies</subject><subject>Regulatory sequences</subject><subject>Reproducibility</subject><subject>Resistance thermometers</subject><subject>Scanners</subject><subject>Software</subject><subject>Standardization</subject><subject>Statistical analysis</subject><subject>Temperature dependence</subject><subject>Temperature requirements</subject><subject>Tubes</subject><subject>Values</subject><issn>1097-6647</issn><issn>1532-429X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkl1rFDEUhgdRbK3-Aa8CgrQXU_Mxk0y8EJZSrbDihSt4F7L52EmZTMYkU6i_wJ9tplu0WyQXyUme9z05yamq1wieI9TRdwlhTrsaYlhDSBGpyZPqGLUE1w3mP56WNeSsprRhR9WLlK4hRJxB9rw6IpiwtuP0uPq9QcDLaXLjDkwm2hC9HJUBctTAG5nmaLwZM4hmMjLLrRtcvn1fwjQPOQEbgwe5N8CX0NWjzC6McgAPXFMuXjJq9-vuEEy9HHNRTTHsovTgdIO-XH47e1k9s3JI5tX9fFJ9_3i5ubiq118_fb5YrWvVUJ5r23KibauIpkg3xraNLFViSSBREGGl9ZZZrJuWc0i2GDXWsI7BTnVcaaMhOak-7H2neeuNVqW4KAcxRedlvBVBOnF4Mrpe7MKNYBg2GONicLY36B_JrlZrsexBUv4FQ3iDCnt6nyyGn7NJWXiXlBkGOZowJ4EJ5x1BlJCCvnmEXoc5lrcsVFMylxoo-kft5GCEG20od1SLqVhRzBrCMFqo8_9QZWjjnQqjsa7sHwjePhD0Rg65T2GYlw9LhyDegyqGlKKxf18AQbE0pdg3pShNKe6aUhDyB_r60m8</recordid><startdate>20200507</startdate><enddate>20200507</enddate><creator>Captur, Gabriella</creator><creator>Bhandari, Abhiyan</creator><creator>Brühl, Rüdiger</creator><creator>Ittermann, Bernd</creator><creator>Keenan, Kathryn E</creator><creator>Yang, Ye</creator><creator>Eames, Richard J</creator><creator>Benedetti, Giulia</creator><creator>Torlasco, Camilla</creator><creator>Ricketts, Lewis</creator><creator>Boubertakh, Redha</creator><creator>Fatih, Nasri</creator><creator>Greenwood, John P</creator><creator>Paulis, Leonie E. 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M ; Lawton, Chris B ; Bucciarelli-Ducci, Chiara ; Lamb, Hildo J ; Steeds, Richard ; Leung, Steve W ; Berry, Colin ; Valentin, Sinitsyn ; Flett, Andrew ; de Lange, Charlotte ; DeCobelli, Francesco ; Viallon, Magalie ; Croisille, Pierre ; Higgins, David M ; Greiser, Andreas ; Pang, Wenjie ; Hamilton-Craig, Christian ; Strugnell, Wendy E ; Dresselaers, Tom ; Barison, Andrea ; Dawson, Dana ; Taylor, Andrew J ; Mongeon, François-Pierre ; Plein, Sven ; Messroghli, Daniel ; Al-Mallah, Mouaz ; Grieve, Stuart M ; Lombardi, Massimo ; Jang, Jihye ; Salerno, Michael ; Chaturvedi, Nish ; Kellman, Peter ; Bluemke, David A ; Nezafat, Reza ; Gatehouse, Peter ; Moon, James C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-f593df5c3d61d4ef54a1092a303c012cddb7f2d459903b214fe78708c89cded03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers</topic><topic>Coefficient of variation</topic><topic>Computer programs</topic><topic>Datasets</topic><topic>Electric equipment industry</topic><topic>Field strength</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Magnets</topic><topic>Mapping</topic><topic>Measurement</topic><topic>Myocardium</topic><topic>Prototypes</topic><topic>Quality assurance</topic><topic>Quality control</topic><topic>Quality standards</topic><topic>Regulatory agencies</topic><topic>Regulatory sequences</topic><topic>Reproducibility</topic><topic>Resistance thermometers</topic><topic>Scanners</topic><topic>Software</topic><topic>Standardization</topic><topic>Statistical analysis</topic><topic>Temperature dependence</topic><topic>Temperature requirements</topic><topic>Tubes</topic><topic>Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Captur, Gabriella</creatorcontrib><creatorcontrib>Bhandari, Abhiyan</creatorcontrib><creatorcontrib>Brühl, Rüdiger</creatorcontrib><creatorcontrib>Ittermann, Bernd</creatorcontrib><creatorcontrib>Keenan, Kathryn E</creatorcontrib><creatorcontrib>Yang, Ye</creatorcontrib><creatorcontrib>Eames, Richard J</creatorcontrib><creatorcontrib>Benedetti, Giulia</creatorcontrib><creatorcontrib>Torlasco, Camilla</creatorcontrib><creatorcontrib>Ricketts, Lewis</creatorcontrib><creatorcontrib>Boubertakh, Redha</creatorcontrib><creatorcontrib>Fatih, Nasri</creatorcontrib><creatorcontrib>Greenwood, John P</creatorcontrib><creatorcontrib>Paulis, Leonie E. M</creatorcontrib><creatorcontrib>Lawton, Chris B</creatorcontrib><creatorcontrib>Bucciarelli-Ducci, Chiara</creatorcontrib><creatorcontrib>Lamb, Hildo J</creatorcontrib><creatorcontrib>Steeds, Richard</creatorcontrib><creatorcontrib>Leung, Steve W</creatorcontrib><creatorcontrib>Berry, Colin</creatorcontrib><creatorcontrib>Valentin, Sinitsyn</creatorcontrib><creatorcontrib>Flett, Andrew</creatorcontrib><creatorcontrib>de Lange, Charlotte</creatorcontrib><creatorcontrib>DeCobelli, Francesco</creatorcontrib><creatorcontrib>Viallon, Magalie</creatorcontrib><creatorcontrib>Croisille, Pierre</creatorcontrib><creatorcontrib>Higgins, David M</creatorcontrib><creatorcontrib>Greiser, Andreas</creatorcontrib><creatorcontrib>Pang, Wenjie</creatorcontrib><creatorcontrib>Hamilton-Craig, Christian</creatorcontrib><creatorcontrib>Strugnell, Wendy E</creatorcontrib><creatorcontrib>Dresselaers, Tom</creatorcontrib><creatorcontrib>Barison, Andrea</creatorcontrib><creatorcontrib>Dawson, Dana</creatorcontrib><creatorcontrib>Taylor, Andrew J</creatorcontrib><creatorcontrib>Mongeon, François-Pierre</creatorcontrib><creatorcontrib>Plein, Sven</creatorcontrib><creatorcontrib>Messroghli, Daniel</creatorcontrib><creatorcontrib>Al-Mallah, Mouaz</creatorcontrib><creatorcontrib>Grieve, Stuart M</creatorcontrib><creatorcontrib>Lombardi, Massimo</creatorcontrib><creatorcontrib>Jang, Jihye</creatorcontrib><creatorcontrib>Salerno, Michael</creatorcontrib><creatorcontrib>Chaturvedi, Nish</creatorcontrib><creatorcontrib>Kellman, Peter</creatorcontrib><creatorcontrib>Bluemke, David A</creatorcontrib><creatorcontrib>Nezafat, Reza</creatorcontrib><creatorcontrib>Gatehouse, Peter</creatorcontrib><creatorcontrib>Moon, James C</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cardiovascular magnetic resonance</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Captur, Gabriella</au><au>Bhandari, Abhiyan</au><au>Brühl, Rüdiger</au><au>Ittermann, Bernd</au><au>Keenan, Kathryn E</au><au>Yang, Ye</au><au>Eames, Richard J</au><au>Benedetti, Giulia</au><au>Torlasco, Camilla</au><au>Ricketts, Lewis</au><au>Boubertakh, Redha</au><au>Fatih, Nasri</au><au>Greenwood, John P</au><au>Paulis, Leonie E. M</au><au>Lawton, Chris B</au><au>Bucciarelli-Ducci, Chiara</au><au>Lamb, Hildo J</au><au>Steeds, Richard</au><au>Leung, Steve W</au><au>Berry, Colin</au><au>Valentin, Sinitsyn</au><au>Flett, Andrew</au><au>de Lange, Charlotte</au><au>DeCobelli, Francesco</au><au>Viallon, Magalie</au><au>Croisille, Pierre</au><au>Higgins, David M</au><au>Greiser, Andreas</au><au>Pang, Wenjie</au><au>Hamilton-Craig, Christian</au><au>Strugnell, Wendy E</au><au>Dresselaers, Tom</au><au>Barison, Andrea</au><au>Dawson, Dana</au><au>Taylor, Andrew J</au><au>Mongeon, François-Pierre</au><au>Plein, Sven</au><au>Messroghli, Daniel</au><au>Al-Mallah, Mouaz</au><au>Grieve, Stuart M</au><au>Lombardi, Massimo</au><au>Jang, Jihye</au><au>Salerno, Michael</au><au>Chaturvedi, Nish</au><au>Kellman, Peter</au><au>Bluemke, David A</au><au>Nezafat, Reza</au><au>Gatehouse, Peter</au><au>Moon, James C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES)</atitle><jtitle>Journal of cardiovascular magnetic resonance</jtitle><date>2020-05-07</date><risdate>2020</risdate><volume>22</volume><issue>1</issue><spage>31</spage><epage>31</epage><pages>31-31</pages><artnum>31</artnum><issn>1097-6647</issn><eissn>1532-429X</eissn><abstract>Background The T.sub.1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T.sub.1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T.sub.1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B.sub.0 and B.sub.1, and "reference" slow T.sub.1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T.sub.1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5 T and 22 3 T magnets using multiple T.sub.1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T.sub.1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T.sub.1 variation. Results Over 2 years, phantom gel integrity remained intact (no rips/tears), B.sub.0 and B.sub.1 homogenous, and "reference" T.sub.1 stable compared to baseline (% change at 1.5 T, 1.95 [+ or -] 1.39%; 3 T, 2.22 [+ or -] 1.44%). Per degrees Celsius, 1.5 T, T.sub.1 (MOLLI 5s(3s)3s) increased by 11.4 ms in long native blood tubes and decreased by 1.2 ms in short post-contrast myocardium tubes. Agreement of estimated T.sub.1 times with "reference" T.sub.1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R.sup.2 ranges for both field strengths, 0.99-1.00). Over 1 year, many 1.5 T and 3 T sequences/magnets were repeatable with mean CoVs < 1 and 2% respectively. Repeatability was narrower for 1.5 T over 3 T. Within T1MES repeatability for native T.sub.1 was narrow for several sequences, for example, at 1.5 T, Siemens MOLLI 5s(3s)3s prototype number 448B (mean CoV = 0.27%) and Philips modified Look-Locker inversion recovery (MOLLI) 3s(3s)5s (CoV 0.54%), and at 3 T, Philips MOLLI 3b(3s)5b (CoV 0.33%) and Siemens shortened MOLLI (ShMOLLI) prototype 780C (CoV 0.69%). After adjusting for temperature and field strength, it was found that the T.sub.1 mapping sequence and scanner software version (both P < 0.001 at 1.5 T and 3 T), and to a lesser extent the scanner model (P = 0.011, 1.5 T only), had the greatest influence on T.sub.1 across multiple centers. Conclusion The T1MES CE/FDA approved phantom is a robust quality assurance device. In a multi-center setting, T.sub.1 mapping had performance differences between field strengths, sequences, scanner software versions, and manufacturers. However, several specific combinations of field strength, sequence, and scanner are highly repeatable, and thus, have potential to provide standardized assessment of T.sub.1 times for clinical use, although temperature correction is required for native T.sub.1 tubes at least. Keywords: T.sub.1 mapping, Standardization, Calibration, Phantom, Repeatability, Extracellular volume</abstract><cop>New York</cop><pub>BioMed Central Ltd</pub><pmid>32375896</pmid><doi>10.1186/s12968-020-00613-3</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3662-3846</orcidid><orcidid>https://orcid.org/0000-0001-9118-0438</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1097-6647 |
| ispartof | Journal of cardiovascular magnetic resonance, 2020-05, Vol.22 (1), p.31-31, Article 31 |
| issn | 1097-6647 1532-429X |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA Free Journals |
| subjects | Biomarkers Coefficient of variation Computer programs Datasets Electric equipment industry Field strength Laboratories Life Sciences Magnets Mapping Measurement Myocardium Prototypes Quality assurance Quality control Quality standards Regulatory agencies Regulatory sequences Reproducibility Resistance thermometers Scanners Software Standardization Statistical analysis Temperature dependence Temperature requirements Tubes Values |
| title | T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES) |
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