Dual-Luciferase-Based Fast and Sensitive Detection of Malaria Hypnozoites for the Discovery of Antirelapse Compounds

Efforts to eradicate Plasmodium vivax malaria are hampered by the presence of hypnozoites, persisting stages in the liver that can reactivate after prolonged periods of time enabling further transmission and causing renewed disease. Large-scale drug screening is needed to identify compounds with ant...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Analytical chemistry (Washington) 2020-05, Vol.92 (9), p.6667-6675
Hauptverfasser:	Voorberg-van der Wel, Annemarie M, Zeeman, Anne-Marie, Nieuwenhuis, Ivonne G, van der Werff, Nicole M, Klooster, Els J, Klop, Onny, Vermaat, Lars C, Kocken, Clemens H. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Antimalarials - pharmacology Bioluminescence Cells, Cultured Chemistry Disease transmission Drug Discovery Drug screening Fluorescence Hepatocytes - drug effects Hepatocytes - parasitology Hsp70 protein Liver Luciferases - metabolism Luminescent Measurements Macaca mulatta Malaria Malaria - diagnostic imaging Malaria - drug therapy Optical Imaging Parasites Parasitic Sensitivity Tests Plasmodium - drug effects Schizonts Vector-borne diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!