Catechol inhibits epidermal growth factor-induced epithelial-to-mesenchymal transition and stem cell-like properties in hepatocellular carcinoma cells

Epithelial-mesenchymal transition (EMT) is a major cellular process in which epithelial cells lose cell polarity and cell-cell adhesion and become motility and invasiveness by transforming into mesenchymal cells. Catechol is one of the natural compounds present in fruits and vegetables and has vario...

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Veröffentlicht in:	Scientific reports 2020-05, Vol.10 (1), p.7620, Article 7620
Hauptverfasser:	Lim, Won-Chul, Kim, Hyunhee, Kim, Young-Joo, Jeon, Bu-Nam, Kang, Hee-Bum, Ko, Hyeonseok
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/67 631/80 AKT protein Anoikis Carcinoma, Hepatocellular - pathology Catechol Catechols - pharmacology Cell adhesion Cell adhesion & migration Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects E-cadherin Enzyme Activation - drug effects Epidermal growth factor Epidermal Growth Factor - pharmacology Epidermal growth factor receptors Epithelial cells Epithelial-Mesenchymal Transition - drug effects ErbB Receptors - metabolism Gene Expression Regulation, Neoplastic - drug effects Growth factors Hepatocellular carcinoma Humanities and Social Sciences Humans Invasiveness Liver cancer Liver Neoplasms - pathology Matrix Metalloproteinase 2 - metabolism Mesenchyme Metastases Metastasis multidisciplinary Neoplasm Invasiveness Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Phenotypes Polarity Proto-Oncogene Proteins c-akt - metabolism Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Snail Family Transcription Factors - metabolism Stem cells Vimentin
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