L-Type amino acid transporter 1 as a target for drug delivery

Our growing understanding of membrane transporters and their substrate specificity has opened a new avenue in the field of targeted drug delivery. The L-type amino acid transporter 1 (LAT1) has been one of the most extensively investigated transporters for delivering drugs across biological barriers...

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Veröffentlicht in:	Pharmaceutical research 2020-05, Vol.37 (5), p.88-88, Article 88
Hauptverfasser:	Puris, Elena, Gynther, Mikko, Auriola, Seppo, Huttunen, Kristiina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antineoplastic Agents - chemistry Antiparkinsonian agents Basal ganglia Biochemistry Biological Transport Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood-brain barrier Blood-Brain Barrier - metabolism Bone marrow Brain Cancer Central Nervous System - metabolism Central nervous system diseases Cerebral cortex Dihydroxyphenylalanine Drug Carriers Drug delivery Drug delivery systems Drug Delivery Systems - methods Drugs Epilepsy Expert Review Gabapentin Humans Large Neutral Amino Acid-Transporter 1 - metabolism Large Neutral Amino Acid-Transporter 1 - therapeutic use Leucine Levodopa Medical Law Melphalan Movement disorders Pharmacology/Toxicology Pharmacy Phenylalanine Physiological aspects Placenta Positron-Emission Tomography Prodrugs Retina Substrate specificity Vehicles
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