Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome
Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3 were investigated for host genetic susceptibil...
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| Veröffentlicht in: | The Journal of infectious diseases 2007-07, Vol.196 (2), p.271-280 |
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| creator | Chan, Kelvin Y. K. Ching, Johannes C. Y. Xu, M. S. Cheung, Annie N. Y. Yip, Shea-Ping Yam, Loretta Y. C. Lai, Sik-To Chu, Chung-Ming Wong, Andrew T. Y. Song, You-Qiang Huang, Fang-Ping Liu, Wei Chung, P. H. Leung, G. M. Chow, Eudora Y. D. Chan, Eric Y. T. Chan, Jane C. K. Ngan, Hextan Tam, Paul Chan, Li-Chong Sham, Pak Chan, Vera S. F. Peiris, Malik Lin, Steve C. L. Khoo, Ui-Soon |
| description | Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3 were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS-CoV infection was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval [CI], 1.37–13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10–0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS. |
| doi_str_mv | 10.1086/518892 |
| format | Article |
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K. ; Ching, Johannes C. Y. ; Xu, M. S. ; Cheung, Annie N. Y. ; Yip, Shea-Ping ; Yam, Loretta Y. C. ; Lai, Sik-To ; Chu, Chung-Ming ; Wong, Andrew T. Y. ; Song, You-Qiang ; Huang, Fang-Ping ; Liu, Wei ; Chung, P. H. ; Leung, G. M. ; Chow, Eudora Y. D. ; Chan, Eric Y. T. ; Chan, Jane C. K. ; Ngan, Hextan ; Tam, Paul ; Chan, Li-Chong ; Sham, Pak ; Chan, Vera S. F. ; Peiris, Malik ; Lin, Steve C. L. ; Khoo, Ui-Soon</creator><creatorcontrib>Chan, Kelvin Y. K. ; Ching, Johannes C. Y. ; Xu, M. S. ; Cheung, Annie N. Y. ; Yip, Shea-Ping ; Yam, Loretta Y. C. ; Lai, Sik-To ; Chu, Chung-Ming ; Wong, Andrew T. Y. ; Song, You-Qiang ; Huang, Fang-Ping ; Liu, Wei ; Chung, P. H. ; Leung, G. M. ; Chow, Eudora Y. D. ; Chan, Eric Y. T. ; Chan, Jane C. K. ; Ngan, Hextan ; Tam, Paul ; Chan, Li-Chong ; Sham, Pak ; Chan, Vera S. F. ; Peiris, Malik ; Lin, Steve C. L. ; Khoo, Ui-Soon</creatorcontrib><description>Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3 were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS-CoV infection was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval [CI], 1.37–13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10–0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/518892</identifier><identifier>PMID: 17570115</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alleles ; Antigens, CD - genetics ; Biological and medical sciences ; Case-Control Studies ; Cell Adhesion Molecules - genetics ; Child ; Child, Preschool ; Control groups ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Genotypes ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Intensive care units ; L-Lactate Dehydrogenase - blood ; Leukocyte Count ; Major and Brief Reports ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; SARS ; SARS coronavirus ; SARS virus ; Severe acute respiratory syndrome ; Severe Acute Respiratory Syndrome - genetics ; Severe Acute Respiratory Syndrome - physiopathology ; T lymphocytes ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Viruses</subject><ispartof>The Journal of infectious diseases, 2007-07, Vol.196 (2), p.271-280</ispartof><rights>Copyright 2007 Infectious Diseases Society of America</rights><rights>2008 INIST-CNRS</rights><rights>2007 by the Infectious Diseases Society of America 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-c4493285b8460bf45e2f49dc52d31942b944ec3629f0d33acfb5c639b9e64c2d3</citedby><cites>FETCH-LOGICAL-c513t-c4493285b8460bf45e2f49dc52d31942b944ec3629f0d33acfb5c639b9e64c2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30086641$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30086641$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18915781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17570115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Kelvin Y. K.</creatorcontrib><creatorcontrib>Ching, Johannes C. Y.</creatorcontrib><creatorcontrib>Xu, M. S.</creatorcontrib><creatorcontrib>Cheung, Annie N. Y.</creatorcontrib><creatorcontrib>Yip, Shea-Ping</creatorcontrib><creatorcontrib>Yam, Loretta Y. C.</creatorcontrib><creatorcontrib>Lai, Sik-To</creatorcontrib><creatorcontrib>Chu, Chung-Ming</creatorcontrib><creatorcontrib>Wong, Andrew T. Y.</creatorcontrib><creatorcontrib>Song, You-Qiang</creatorcontrib><creatorcontrib>Huang, Fang-Ping</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Chung, P. H.</creatorcontrib><creatorcontrib>Leung, G. M.</creatorcontrib><creatorcontrib>Chow, Eudora Y. D.</creatorcontrib><creatorcontrib>Chan, Eric Y. T.</creatorcontrib><creatorcontrib>Chan, Jane C. K.</creatorcontrib><creatorcontrib>Ngan, Hextan</creatorcontrib><creatorcontrib>Tam, Paul</creatorcontrib><creatorcontrib>Chan, Li-Chong</creatorcontrib><creatorcontrib>Sham, Pak</creatorcontrib><creatorcontrib>Chan, Vera S. F.</creatorcontrib><creatorcontrib>Peiris, Malik</creatorcontrib><creatorcontrib>Lin, Steve C. L.</creatorcontrib><creatorcontrib>Khoo, Ui-Soon</creatorcontrib><title>Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3 were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS-CoV infection was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval [CI], 1.37–13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10–0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Antigens, CD - genetics</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Control groups</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Intensive care units</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Leukocyte Count</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>SARS</subject><subject>SARS coronavirus</subject><subject>SARS virus</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe Acute Respiratory Syndrome - genetics</subject><subject>Severe Acute Respiratory Syndrome - physiopathology</subject><subject>T lymphocytes</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EoqHAPwDtBW4L_v64IKURtEAQgkKpuFhe7yx1u1kH2ynk37NRogROnObwPHpnNC9Cjwl-QbCWLwXR2tA7aEIEU7WUhN1FE4wprYk25gg9yPkaY8yZVPfREVFCYULEBL2f5hx9cCXEoYpd9XY2_cCqUxigBF9duBTcUKpfoVxV53ALCaqpXxWoPkNehuRKTOvqfD20KS7gIbrXuT7Do908Rl_fvP4yO6vnH0_H3HntBWGl9pwbRrVoNJe46bgA2nHTekFbRgynjeEcPJPUdLhlzPmuEV4y0xiQ3I_SMXq1zV2umgW0HoaSXG-XKSxcWtvogv2XDOHK_oi3VlFMOZZjwPNdQIo_V5CLXYTsoe_dAHGVrcKSEk34f0WKxfhpRQ6iTzHnBN3-GoLtpiC7LWgUn_59-0HbNTIKz3aCy971XXKDD_ngaUOE0puNT7bedR5L2HOGx2WSb3i95SEX-L3nLt1YqZgS9uzyu333aXYyv_x2Yi_YHzo8r9w</recordid><startdate>20070715</startdate><enddate>20070715</enddate><creator>Chan, Kelvin Y. 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L.</creator><creator>Khoo, Ui-Soon</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070715</creationdate><title>Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome</title><author>Chan, Kelvin Y. K. ; Ching, Johannes C. Y. ; Xu, M. S. ; Cheung, Annie N. Y. ; Yip, Shea-Ping ; Yam, Loretta Y. C. ; Lai, Sik-To ; Chu, Chung-Ming ; Wong, Andrew T. Y. ; Song, You-Qiang ; Huang, Fang-Ping ; Liu, Wei ; Chung, P. H. ; Leung, G. M. ; Chow, Eudora Y. D. ; Chan, Eric Y. T. ; Chan, Jane C. 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L. ; Khoo, Ui-Soon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-c4493285b8460bf45e2f49dc52d31942b944ec3629f0d33acfb5c639b9e64c2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Antigens, CD - genetics</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Control groups</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intensive care units</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Leukocyte Count</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>SARS</topic><topic>SARS coronavirus</topic><topic>SARS virus</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe Acute Respiratory Syndrome - genetics</topic><topic>Severe Acute Respiratory Syndrome - physiopathology</topic><topic>T lymphocytes</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Kelvin Y. 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K.</au><au>Ching, Johannes C. Y.</au><au>Xu, M. S.</au><au>Cheung, Annie N. Y.</au><au>Yip, Shea-Ping</au><au>Yam, Loretta Y. C.</au><au>Lai, Sik-To</au><au>Chu, Chung-Ming</au><au>Wong, Andrew T. Y.</au><au>Song, You-Qiang</au><au>Huang, Fang-Ping</au><au>Liu, Wei</au><au>Chung, P. H.</au><au>Leung, G. M.</au><au>Chow, Eudora Y. D.</au><au>Chan, Eric Y. T.</au><au>Chan, Jane C. K.</au><au>Ngan, Hextan</au><au>Tam, Paul</au><au>Chan, Li-Chong</au><au>Sham, Pak</au><au>Chan, Vera S. F.</au><au>Peiris, Malik</au><au>Lin, Steve C. L.</au><au>Khoo, Ui-Soon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2007-07-15</date><risdate>2007</risdate><volume>196</volume><issue>2</issue><spage>271</spage><epage>280</epage><pages>271-280</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3 were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute respiratory syndrome (SARS), 307 health care worker control subjects, 290 outpatient control subjects, and 309 household control subjects unaffected by SARS from Hong Kong was conducted to test for genetic association. No significant association to susceptibility to SARS-CoV infection was found for the FCER2 and the ICAM3 single nucleotide polymorphisms. However, patients with SARS homozygous for ICAM3 Gly143 showed significant association with higher lactate dehydrogenase levels (P=.0067; odds ratio [OR], 4.31 [95% confidence interval [CI], 1.37–13.56]) and lower total white blood cell counts (P=.022; OR, 0.30 [95% CI, 0.10–0.89]) on admission. These findings support the role of ICAM3 in the immunopathogenesis of SARS.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>17570115</pmid><doi>10.1086/518892</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2007-07, Vol.196 (2), p.271-280 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; Oxford Academic Journals (OUP); Alma/SFX Local Collection; JSTOR |
| subjects | Adolescent Adult Aged Aged, 80 and over Alleles Antigens, CD - genetics Biological and medical sciences Case-Control Studies Cell Adhesion Molecules - genetics Child Child, Preschool Control groups Female Gene Frequency Genetic Predisposition to Disease Genotype Genotypes Human viral diseases Humans Infections Infectious diseases Intensive care units L-Lactate Dehydrogenase - blood Leukocyte Count Major and Brief Reports Male Medical sciences Middle Aged Polymorphism, Single Nucleotide - genetics SARS SARS coronavirus SARS virus Severe acute respiratory syndrome Severe Acute Respiratory Syndrome - genetics Severe Acute Respiratory Syndrome - physiopathology T lymphocytes Viral diseases Viral diseases of the respiratory system and ent viral diseases Viruses |
| title | Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome |
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